GLENDA PRISCILA NEVES DOS SANTOS BEOZZO

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Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina - Médico

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  • article 0 Citação(ões) na Scopus
    Establishment of oral microbiome in very low birth weight infants during the first weeks of life and the impact of oral diet implementation
    (2023) VANZELE, Pedro A. R.; SPARVOLI, Luiz Gustavo; CAMARGO, Patricia P. de; TRAGANTE, Carla R.; BEOZZO, Glenda P. N. S.; KREBS, Vera L. J.; CORTEZ, Ramon V.; TADDEI, Carla R.
    Very low birth weight (VLBW) infants, mostly preterm, have many barriers to feeding directly from the mother's breast, and need to be fed alternatively. Feeding is a major influencer in oral microbial colonization, and this colonization in early life is crucial for the promotion of human health. Therefore, this research aimed to observe the establishment of oral microbiome in VLBW infants during their first month of life through hospitalization, and to verify the impact caused by the implementation of oral diet on the colonization of these newborns. We included 23 newborns followed during hospitalization and analyzed saliva samples collected weekly, using 16S rRNA gene sequencing. We observed a significant decrease in richness and diversity and an increase in dominance over time (q-value < 0.05). The oral microbiome is highly dynamic during the first weeks of life, and beta diversity suggests a microbial succession in early life. The introduction of oral diet does not change the community structure, but affects the abundance, especially of Streptococcus. Our results indicate that although time is related to significant changes in the oral microbial profile, oral feeding benefits genera that will remain colonizers throughout the host's life.
  • article 5 Citação(ões) na Scopus
    Use of budesonide associated with a pulmonary surfactant to prevent bronchopulmonary dysplasia in premature newborns- A systematic review
    (2023) MORAES, Lucas Hirano Arruda; COELHO, Rachel Mocelin Dias; BEOZZO, Glenda Priscila Neves dos Santos; YOSHIDA, Renata de Araujo Monteiro; DINIZ, Edna Maria de Albuquerque; CARVALHO, Werther Brunow de
    Objective: Among the mechanisms proposed for the development of bronchopulmonary dysplasia is the increase in the pulmonary inflammatory process and oxidative stress. Thus, the control of this process may result in improvements in bronchopulmonary dysplasia-related outcomes. This study aims to analyze the current scientific evidence regarding the use of budesonide, a potent anti-inflammatory drug, associated with a pulmonary surfactant to prevent bronchopulmonary dysplasia.Methods: A systematic review of the literature was performed on the Embase and MEDLINE plat-forms, and studies that compared budesonide with pulmonary surfactant versus pulmonary sur-factant for treating respiratory distress syndrome were included. The primary outcome was a reduction in bronchopulmonary dysplasia or death. Results: Four randomized clinical trials and two observational studies were included in this systematic review. Three of the randomized clinical trials found a reduction in bronchopulmonary dysplasia or death in the use of budesonide with the surfactant, all the other studies (1 clinical trial and 2 observa-tional studies) found no statistical differences between the groups for the primary outcomes. The three main studies showed a reduction in the primary outcome; however, all studies showed great heteroge-neity regarding the type of surfactant (poractant or beractant) and the method of administration. Conclusion: Robust clinical studies, in a heterogeneous population, using porcine surfactant associated with budesonide, with administration by a minimally invasive technique are necessary for there to be a recommendation based on scientific evidence for its widespread use.(c) 2022 Sociedade Brasileira de Pediatria.