Oral squamous cell carcinoma cancer stem cells have different drug sensitive to pharmacological NFκB and histone deacetylation inhibition

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSILVA, Luan Cesar
dc.contributor.authorLEITE, Amanda Almeida
dc.contributor.authorBORGATO, Gabriell Bonifacio
dc.contributor.authorWAGNER, Vivian Petersen
dc.contributor.authorMARTINS, Manoela Domingues
dc.contributor.authorLOUREIRO, Felippe Jose Almeida
dc.contributor.authorLOPES, Marcio Ajudarte
dc.contributor.authorSANTOS-SILVA, Alan Roger
dc.contributor.authorSPERANDIO, Marcelo
dc.contributor.authorJUNIOR, Gilberto de Castro
dc.contributor.authorKOWALSKI, Luiz Paulo
dc.contributor.authorSQUARIZE, Cristiane H.
dc.contributor.authorCASTILHO, Rogerio Moraes
dc.contributor.authorVARGAS, Pablo Agustin
dc.date.accessioned2024-02-15T14:40:47Z
dc.date.available2024-02-15T14:40:47Z
dc.date.issued2023
dc.description.abstractDespite many progresses in the development of new systemic therapies for oral squamous cell carcinoma (OSCC), the five-year survival rate of OSCC is low. The traditional chemotherapies approach (cisplatin - CDDP) shows some limitations like drug toxicity, limited efficacy, and drug resistance. Promising studies suggested OSCC cancer stem cells (CSC) presented resistance to CDDP. We have previously studied many targets, and we extensively showed the efficacy of the NF kappa B signaling and the role of histones acetylation, on different malignant tumors, including adenoid cystic carcinoma and mucoepidermoid carcinoma, but until then the effects of the NFkB inhibitor and histone deacetylase (HDAC) inhibitor on the biology of OSCC were not evaluated. Here we assessed the pharmacological inhibitor of NF kappa B emetine and HDAC inhibitor SAHA on the behavior of CSC derived from OSCC. Our data suggested that CDDP administration resulted in reduced viability of bulk OSCC cells and increased CSC. A single and isolated shot of emetine and SAHA were able to disrupt CSC by inhibiting the NF kappa B pathway and increasing the histone acetylation levels, respectively. Further, the combined administration of emetine and SAHA presented the same CSC disruption as seen in emetine alone.eng
dc.description.indexPubMed
dc.description.indexWoS
dc.description.sponsorshipState of Sao Paulo Funding Agency (FAPESP) [2016/05710-4]
dc.description.sponsorshipCoordination of Improvement of Higher Education Personnel (CAPES), Brazil [001]
dc.description.sponsorshipFAPESP (State of Sao Paulo Funding Agency) [2019/06597-5, 2021/13381-9]
dc.identifier.citationAMERICAN JOURNAL OF CANCER RESEARCH, v.13, n.12, p.6038-6050, 2023
dc.identifier.issn2156-6976
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/57914
dc.language.isoeng
dc.publisherE-CENTURY PUBLISHING CORPeng
dc.relation.ispartofAmerican Journal of Cancer Research
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright E-CENTURY PUBLISHING CORPeng
dc.subjectHead and neck tumorseng
dc.subjectoral squamous cell carcinomaeng
dc.subjectchemotherapyeng
dc.subjecttarget therapyeng
dc.subjectcancer stem celleng
dc.subject.otherheadeng
dc.subject.otherexpressioneng
dc.subject.othercisplatineng
dc.subject.othertherapyeng
dc.subject.otheremetineeng
dc.subject.wosOncologyeng
dc.titleOral squamous cell carcinoma cancer stem cells have different drug sensitive to pharmacological NFκB and histone deacetylation inhibitioneng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryInglaterra
hcfmusp.affiliation.countryisous
hcfmusp.affiliation.countryisogb
hcfmusp.author.externalSILVA, Luan Cesar:Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba, SP, Brazil; Univ Michigan, Sch Dent, Dept Periodont & Oral Med, Lab Epithelial Biol, Ann Arbor, MI USA
hcfmusp.author.externalLEITE, Amanda Almeida:Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba, SP, Brazil
hcfmusp.author.externalBORGATO, Gabriell Bonifacio:Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba, SP, Brazil
hcfmusp.author.externalWAGNER, Vivian Petersen:Univ Sheffield, Dept Clin Dent, Acad Unit Oral & Maxillofacial Med & Pathol, Sheffield, England
hcfmusp.author.externalMARTINS, Manoela Domingues:Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba, SP, Brazil; Univ Fed Rio Grande do Sul, Sch Dent, Dept Oral Pathol, Porto Alegre, Brazil
hcfmusp.author.externalLOUREIRO, Felippe Jose Almeida:Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba, SP, Brazil
hcfmusp.author.externalLOPES, Marcio Ajudarte:Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba, SP, Brazil
hcfmusp.author.externalSANTOS-SILVA, Alan Roger:Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba, SP, Brazil
hcfmusp.author.externalSPERANDIO, Marcelo:Sao Leopoldo Mand Dent Inst & Res Ctr, Dept Oral Pathol, Campinas, SP, Brazil
hcfmusp.author.externalSQUARIZE, Cristiane H.:Univ Michigan, Sch Dent, Dept Periodont & Oral Med, Lab Epithelial Biol, Ann Arbor, MI USA
hcfmusp.author.externalCASTILHO, Rogerio Moraes:Univ Michigan, Sch Dent, Dept Periodont & Oral Med, Lab Epithelial Biol, Ann Arbor, MI USA
hcfmusp.author.externalVARGAS, Pablo Agustin:Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba, SP, Brazil; Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Av Limeira 901, BR-13414016 Piracicaba, SP, Brazil
hcfmusp.contributor.author-fmusphcGILBERTO DE CASTRO JUNIOR
hcfmusp.contributor.author-fmusphcLUIZ PAULO KOWALSKI
hcfmusp.description.beginpage6038
hcfmusp.description.endpage6050
hcfmusp.description.issue12
hcfmusp.description.volume13
hcfmusp.origemWOS
hcfmusp.origem.pubmed38187064
hcfmusp.origem.wosWOS:001135869900019
hcfmusp.publisher.cityMADISONeng
hcfmusp.publisher.countryUSAeng
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