Giant cell bone lesions in the craniofacial region: a diagnostic and therapeutic challenge

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorBORGES, Bruno Barros Pinto
dc.contributor.authorFORNAZIERI, Marco Aurelio
dc.contributor.authorBEZERRA, Ana Paula Correia de Araujo
dc.contributor.authorMARTINS, Leandro Aurelio Liporoni
dc.contributor.authorPINNA, Fabio de Rezende
dc.contributor.authorVOEGELS, Richard Louis
dc.date.accessioned2013-07-30T15:14:12Z
dc.date.available2013-07-30T15:14:12Z
dc.date.issued2012
dc.description.abstractBackground: Giant cell tumors of bone (GCTs) are common in the long bones, but rare in the craniofacial region, with only 1% of cases occurring in the latter. Clinical, radiological, and anatomical diagnosis of this locally aggressive disease, which occurs in response to trauma or neoplastic transformation, poses a major challenge in clinical practice. Methods: The present study describes a series of 4 cases and highlights the main features of the differential diagnosis and treatment of these lesions: GCT, giant cell reparative granuloma (GCRG), and the brown tumor of hyperparathyroidism. Results: GCT presents as a benign neoplasm, most typically affecting the knees, and rarely in the temporal and sphenoid bones. It is radiologically indistinguishable from GCRG due to its lytic, poorly defined appearance. The distinction can only be made microscopically, as the presence of multinucleated giant cells scattered throughout the stroma and the absence of a history of trauma favor a diagnosis of GCT. The brown tumor of hyperparathyroidism occurs with rapid, localized osteoclast activity secondary to the effects of increased parathyroid hormone (PTH) levels; parathyroid examination is indispensable. Conclusion: The diagnosis and treatment of these lesions poses a major challenge due to their similar clinical presentation and radiological appearance. Accurate diagnosis is essential for definition of appropriate management, as complete resection is the goal in GCT and GCRG to avoid recurrence, whereas the brown tumor often yields to treatment of the underlying hyperparathyroidism.
dc.description.indexMEDLINE
dc.identifier.citationINTERNATIONAL FORUM OF ALLERGY & RHINOLOGY, v.2, n.6, p.501-506, 2012
dc.identifier.doi10.1002/alr.21050
dc.identifier.issn2042-6976
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/901
dc.language.isoeng
dc.publisherWILEY-BLACKWELL
dc.relation.ispartofInternational Forum of Allergy & Rhinology
dc.rightsrestrictedAccess
dc.rights.holderCopyright WILEY-BLACKWELL
dc.subjectgiant cell tumors
dc.subjectgiant cell granuloma
dc.subjectbrown tumor
dc.subjectcraniofacial region
dc.subjectbone neoplasms
dc.subject.otherreparative granuloma
dc.subject.othertumor
dc.subject.wosOtorhinolaryngology
dc.titleGiant cell bone lesions in the craniofacial region: a diagnostic and therapeutic challenge
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus8
hcfmusp.contributor.author-fmusphcMARCO AURELIO FORNAZIERI
hcfmusp.contributor.author-fmusphcLEANDRO AURELIO LIPORONI MARTINS
hcfmusp.contributor.author-fmusphcFABIO DE REZENDE PINNA
hcfmusp.contributor.author-fmusphcRICHARD LOUIS VOEGELS
hcfmusp.description.beginpage501
hcfmusp.description.endpage506
hcfmusp.description.issue6
hcfmusp.description.volume2012
hcfmusp.lim.ref2012
hcfmusp.origemWOS
hcfmusp.origem.pubmed22566483
hcfmusp.origem.scopus2-s2.0-84870701492
hcfmusp.origem.wosWOS:000312142200011
hcfmusp.publisher.cityHOBOKEN
hcfmusp.publisher.countryUSA
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hcfmusp.scopus.lastupdate2024-04-12
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