White matter microstructure associated with anhedonia among individuals with bipolar disorders and high-risk for bipolar disorders

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorDIAZ, Alexandre Paim
dc.contributor.authorFERNANDES, Brisa S.
dc.contributor.authorTEIXEIRA, Antonio Lucio
dc.contributor.authorMWANGI, Benson
dc.contributor.authorHASAN, Khader M.
dc.contributor.authorWU, Mon-Ju
dc.contributor.authorSELVARAJ, Sudhakar
dc.contributor.authorSUEN, Paulo
dc.contributor.authorZANAO, Tamires Araujo
dc.contributor.authorBRUNONI, Andre R.
dc.contributor.authorSANCHES, Marsal
dc.contributor.authorSOARES, Jair C.
dc.date.accessioned2022-02-24T17:13:20Z
dc.date.available2022-02-24T17:13:20Z
dc.date.issued2022
dc.description.abstractBackground: Anhedonia - a key symptom of depression - is highly associated with poorer outcomes and suicidal behavior. Alterations in the circuitry of reward-related brain regions have been robustly associated with anhedonia in unipolar depression, but not bipolar disorder (BD). We investigated white matter microstructures associated with anhedonia in participants with BD types I and II and first-degree relatives of patients with BD (BD-siblings). Methods: Eighty participants (BD types I and II: 56 [70%], and BD-siblings: 24 [30%]) underwent diffusion tensor imaging (DTI); Fractional anisotropy (FA) of different tracts were computed. Anhedonia was assessed using item 8, (""inability to feel"") of the MADRS scale. General linear models were used to compare the FA of different tracts in participants with and without anhedonia controlling for several clinical and demographic variables. Results: The mean age of the sample was 37 (+/- 11) years old, and 68.8% were female. Participants with anhedonia (32.5%) presented lower mean FA in the left uncinate fasciculus (UF) (p = 0.005), right temporal endings of the superior longitudinal fasciculus (SLFT) (p = 0.04), and in the left and right parietal endings of the superior longitudinal fasciculus (SLFP) (p = 0.003, and p = 0.04, respectively). Similar comparisons between participants with or without current depressive episodes and between participants with or without inner tension according to the MADRS did not show significant differences, specificity of the findings for anhedonia. Conclusions: Lower FA in the left UF and SLF are potential neuroimaging markers of anhedonia in individuals with BD and high-risk for BD.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipNIMHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH) [R01MH085667]
dc.description.sponsorshipBrain & Behavior Research FoundationNARSAD
dc.identifier.citationJOURNAL OF AFFECTIVE DISORDERS, v.300, p.91-98, 2022
dc.identifier.doi10.1016/j.jad.2021.12.037
dc.identifier.eissn1573-2517
dc.identifier.issn0165-0327
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/44327
dc.language.isoeng
dc.publisherELSEVIEReng
dc.relation.ispartofJournal of Affective Disorders
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright ELSEVIEReng
dc.subjectBipolar disorderseng
dc.subjectNeuroimagingeng
dc.subjectAnhedoniaeng
dc.subjectOrbitofrontal cortexeng
dc.subjectNucleus accumbenseng
dc.subjectDiffusion tensor imagingeng
dc.subjectBiomarkereng
dc.subject.otheruncinate fasciculuseng
dc.subject.otherdiffusioneng
dc.subject.otherdepressioneng
dc.subject.otherabnormalitieseng
dc.subject.otherconnectivityeng
dc.subject.otheremotioneng
dc.subject.otheranatomyeng
dc.subject.wosClinical Neurologyeng
dc.subject.wosPsychiatryeng
dc.titleWhite matter microstructure associated with anhedonia among individuals with bipolar disorders and high-risk for bipolar disorderseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalDIAZ, Alexandre Paim:Univ Texas Hlth Sci Ctr Houston, Louis A Faillace MD Dept Psychiat & Behav Sci, 1941 East Rd,Suite 3130, Houston, TX 77054 USA
hcfmusp.author.externalFERNANDES, Brisa S.:Univ Texas Hlth Sci Ctr Houston, Louis A Faillace MD Dept Psychiat & Behav Sci, 1941 East Rd,Suite 3130, Houston, TX 77054 USA
hcfmusp.author.externalTEIXEIRA, Antonio Lucio:Univ Texas Hlth Sci Ctr Houston, Louis A Faillace MD Dept Psychiat & Behav Sci, 1941 East Rd,Suite 3130, Houston, TX 77054 USA
hcfmusp.author.externalMWANGI, Benson:Univ Texas Hlth Sci Ctr Houston, Louis A Faillace MD Dept Psychiat & Behav Sci, 1941 East Rd,Suite 3130, Houston, TX 77054 USA
hcfmusp.author.externalHASAN, Khader M.:Univ Texas Hlth Sci Ctr Houston, Diffus MRI Res Lab, Dept Diagnost & Intervent Imaging, Houston, TX 77030 USA
hcfmusp.author.externalWU, Mon-Ju:Univ Texas Hlth Sci Ctr Houston, Louis A Faillace MD Dept Psychiat & Behav Sci, 1941 East Rd,Suite 3130, Houston, TX 77054 USA
hcfmusp.author.externalSELVARAJ, Sudhakar:Univ Texas Hlth Sci Ctr Houston, Louis A Faillace MD Dept Psychiat & Behav Sci, 1941 East Rd,Suite 3130, Houston, TX 77054 USA
hcfmusp.author.externalSANCHES, Marsal:Univ Texas Hlth Sci Ctr Houston, Louis A Faillace MD Dept Psychiat & Behav Sci, 1941 East Rd,Suite 3130, Houston, TX 77054 USA
hcfmusp.author.externalSOARES, Jair C.:Univ Texas Hlth Sci Ctr Houston, Louis A Faillace MD Dept Psychiat & Behav Sci, 1941 East Rd,Suite 3130, Houston, TX 77054 USA
hcfmusp.citation.scopus5
hcfmusp.contributor.author-fmusphcPAULO JENG CHIAN SUEN
hcfmusp.contributor.author-fmusphcTAMIRES ARAUJO ZANAO MARIANO
hcfmusp.contributor.author-fmusphcANDRE RUSSOWSKY BRUNONI
hcfmusp.description.beginpage91
hcfmusp.description.endpage98
hcfmusp.description.volume300
hcfmusp.origemWOS
hcfmusp.origem.pubmed34936916
hcfmusp.origem.scopus2-s2.0-85121902189
hcfmusp.origem.wosWOS:000740323500013
hcfmusp.publisher.cityAMSTERDAMeng
hcfmusp.publisher.countryNETHERLANDSeng
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