Higher Prevalence of TDP-43 Proteinopathy in Cognitively Normal Asians: A Clinicopathological Study on a Multiethnic Sample

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorNASCIMENTO, Camila
dc.contributor.authorSUEMOTO, Claudia K.
dc.contributor.authorRODRIGUEZ, Roberta D.
dc.contributor.authorALHO, Ana Tereza Di Lorenzo
dc.contributor.authorLEITE, Renata P.
dc.contributor.authorFARFEL, Jose Marcelo
dc.contributor.authorPASQUALUCCI, Carlos Augusto Goncalves
dc.contributor.authorJACOB-FILHO, Wilson
dc.contributor.authorGRINBERG, Lea T.
dc.date.accessioned2016-07-18T11:40:51Z
dc.date.available2016-07-18T11:40:51Z
dc.date.issued2016
dc.description.abstractTransactive response DNA binding protein 43 (TDP-43) proteinopathy is the major hallmark of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. It is also present in a subset of Alzheimer's disease cases. Recently, few reports showed TDP-43 changes in cognitively normal elderly. In Caucasians, TDP-43 proteinopathy independently correlate with cognitive decline. However, it is challenging to establish direct links between cognitive and/or neuropsychiatric symptoms and protein inclusions in neurodegenerative diseases because individual cognitive reserves modify the threshold for clinical disease expression. Cognitive reserve is influenced by demographic, environmental and genetic factors. We investigated the relationships between demographic, clinical and neuropathological variables and TDP-43 proteinopathy in a large multiethnic sample of cognitively normal elderly. TDP-43 proteinopathy was identified in 10.5%, independently associated with older age (P=0.03) and Asian ethnicity (P=0.002). Asians showed a higher prevalence of TDP-43 proteinopathy than Caucasians, even after adjustment for sex, age, Braak stage and schooling (odds ratio=3.50, confidence interval 1.41-8.69, P=0.007). These findings suggested that Asian older adults may be protected from the clinical manifestation of brain TDP-43 proteinopathy. Future studies are needed to identify possible race-related protective factors against clinical expression of TDP-43 proteinopathies.
dc.description.indexMEDLINE
dc.description.sponsorshipSao Paulo Research Foundation
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2011/19833-7, 2012/07526-5, 2010/06521-4]
dc.description.sponsorshipCAPES [99999.012331/2013-09]
dc.description.sponsorshipinstitutional NIH grants [P50AG023501, P01AG019724, R01 AG040311]
dc.identifier.citationBRAIN PATHOLOGY, v.26, n.2, p.177-185, 2016
dc.identifier.doi10.1111/bpa.12296
dc.identifier.eissn1750-3639
dc.identifier.issn1015-6305
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/14140
dc.language.isoeng
dc.publisherWILEY-BLACKWELL
dc.relation.ispartofBrain Pathology
dc.rightsrestrictedAccess
dc.rights.holderCopyright WILEY-BLACKWELL
dc.subjectAsian
dc.subjectautopsy
dc.subjectcognitively normal elderly
dc.subjectdementia
dc.subjectpostmortem
dc.subjectrace
dc.subjectTDP-43 proteinopathy
dc.subject.otherfrontotemporal lobar degeneration
dc.subject.otheramyotrophic-lateral-sclerosis
dc.subject.otheralzheimers-disease
dc.subject.otherhippocampal sclerosis
dc.subject.otherargyrophilic grains
dc.subject.otherneuropsychiatric inventory
dc.subject.othercautionary note
dc.subject.otherlewy bodies
dc.subject.otherdementia
dc.subject.otherpathology
dc.subject.wosClinical Neurology
dc.subject.wosNeurosciences
dc.subject.wosPathology
dc.titleHigher Prevalence of TDP-43 Proteinopathy in Cognitively Normal Asians: A Clinicopathological Study on a Multiethnic Sample
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus24
hcfmusp.contributor.author-fmusphcCAMILA NASCIMENTO MANTELLI
hcfmusp.contributor.author-fmusphcCLAUDIA KIMIE SUEMOTO
hcfmusp.contributor.author-fmusphcROBERTA DIEHL RODRIGUEZ
hcfmusp.contributor.author-fmusphcANA TEREZA DI LORENZO ALHO
hcfmusp.contributor.author-fmusphcRENATA ELAINE PARAIZO LEITE
hcfmusp.contributor.author-fmusphcJOSE MARCELO FARFEL
hcfmusp.contributor.author-fmusphcCARLOS AUGUSTO GONCALVES PASQUALUCCI
hcfmusp.contributor.author-fmusphcWILSON JACOB FILHO
hcfmusp.contributor.author-fmusphcLEA TENENHOLZ GRINBERG
hcfmusp.description.beginpage177
hcfmusp.description.endpage185
hcfmusp.description.issue2
hcfmusp.description.volume26
hcfmusp.origemWOS
hcfmusp.origem.pubmed26260327
hcfmusp.origem.scopus2-s2.0-84941710565
hcfmusp.origem.wosWOS:000373130500004
hcfmusp.publisher.cityHOBOKEN
hcfmusp.publisher.countryUSA
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