In Situ Immune Response in Human Chromoblastomycosis - A Possible Role for Regulatory and Th17 T Cells

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSILVA, Aline Alves de Lima
dc.contributor.authorCRIADO, Paulo Ricardo
dc.contributor.authorNUNES, Ricardo Spina
dc.contributor.authorSILVA, Wellington Luiz Ferreira da
dc.contributor.authorKANASHIRO-GALO, Luciane
dc.contributor.authorDUARTE, Maria Irma Seixas
dc.contributor.authorSOTTO, Mirian N.
dc.contributor.authorPAGLIARI, Carla
dc.date.accessioned2015-02-06T19:47:49Z
dc.date.available2015-02-06T19:47:49Z
dc.date.issued2014
dc.description.abstractBackground: Chromoblastomycosis is a chronic fungal infection that affects skin and subcutaneous tissue. Lesions can be classified in tumorous, verrucous, cicatricial and plaque type. The cellular immune response in the severe form of the disease seems to correlate with a Th2 pattern of cytokines. The humoral immune response also seems to play a role. We intended to explore the populations of regulatory T cells and the Th17 pattern. Methodology: Twenty-three biopsies of verrucous form were obtained from patients with clinical, culture and histopathological diagnostic of chromoblastomycosis, without treatment. It was performed an immunohistochemistry method to detect Foxp3, CD25, TGF-beta, IL-6, IL-17 and IL-23. Principal findings: IL-17 was the only cytokine with high expression in CBM when compared to normal skin. The expression of Treg cells, TGF-beta, IL-6 and IL-23 were similar to normal skin. Conclusions/Significance: The constitution of a local immune response with high expression of IL-17 and low expression of other cytokines could be at least in part, an attempt to help the immune system against fungal infection. On the other hand, high levels of local immune response mediated by Th17 profile could overcome the role of Treg cells. The inefficient immunomodulation as a consequence of the unbalance by Treg/Th17 cells seems to corroborate with the less effective immune response against fungi.
dc.description.indexMEDLINE
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, Brasil) [2013/07994-1]
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.identifier.citationPLOS NEGLECTED TROPICAL DISEASES, v.8, n.9, article ID e3162, 7p, 2014
dc.identifier.doi10.1371/journal.pntd.0003162
dc.identifier.issn1935-2735
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/8618
dc.language.isoeng
dc.publisherPUBLIC LIBRARY SCIENCE
dc.relation.ispartofPlos Neglected Tropical Diseases
dc.rightsopenAccess
dc.rights.holderCopyright PUBLIC LIBRARY SCIENCE
dc.subject.otherdifferent clinical forms
dc.subject.othergrowth-factor-beta
dc.subject.otherfonsecaea-pedrosoi
dc.subject.otherfoxp3
dc.subject.othercytokines
dc.subject.otherparacoccidioidomycosis
dc.subject.otherdifferentiation
dc.subject.otherinhibition
dc.subject.otherinduction
dc.subject.othermycoses
dc.subject.wosInfectious Diseases
dc.subject.wosParasitology
dc.subject.wosTropical Medicine
dc.titleIn Situ Immune Response in Human Chromoblastomycosis - A Possible Role for Regulatory and Th17 T Cells
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalNUNES, Ricardo Spina:Univ Sao Paulo, Fac Med, Lab Dermatopatol, Dept Dermatol, Sao Paulo, Brazil
hcfmusp.citation.scopus21
hcfmusp.contributor.author-fmusphcALINE ALVES DE LIMA SILVA
hcfmusp.contributor.author-fmusphcPAULO RICARDO CRIADO
hcfmusp.contributor.author-fmusphcWELLINGTON LUIZ FERREIRA DA SILVA
hcfmusp.contributor.author-fmusphcLUCIANE KANASHIRO GALO
hcfmusp.contributor.author-fmusphcMARIA IRMA SEIXAS DUARTE
hcfmusp.contributor.author-fmusphcMIRIAN NACAGAMI SOTTO
hcfmusp.contributor.author-fmusphcCARLA PAGLIARI
hcfmusp.description.articlenumbere3162
hcfmusp.description.issue9
hcfmusp.description.volume8
hcfmusp.origemWOS
hcfmusp.origem.scopus2-s2.0-84907573396
hcfmusp.origem.wosWOS:000342796600043
hcfmusp.publisher.citySAN FRANCISCO
hcfmusp.publisher.countryUSA
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