Biomaterials for Pelvic Floor Reconstructive Surgery: How Can We Do Better?

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorGIGLIOBIANCO, Giulia
dc.contributor.authorREGUEROS, Sabiniano Roman
dc.contributor.authorOSMAN, Nadir I.
dc.contributor.authorBISSOLI, Julio
dc.contributor.authorBULLOCK, Anthony J.
dc.contributor.authorCHAPPLE, Chris R.
dc.contributor.authorMACNEIL, Sheila
dc.date.accessioned2015-08-14T15:41:24Z
dc.date.available2015-08-14T15:41:24Z
dc.date.issued2015
dc.description.abstractStress urinary incontinence (SUI) and pelvic organ prolapse (POP) are major health issues that detrimentally impact the quality of life of millions of women worldwide. Surgical repair is an effective and durable treatment for both conditions. Over the past two decades there has been a trend to enforce or reinforce repairs with synthetic and biological materials. The determinants of surgical outcome are many, encompassing the physical and mechanical properties of the material used, and individual immune responses, as well surgical and constitutional factors. Of the current biomaterials in use none represents an ideal. Biomaterials that induce limited inflammatory response followed by constructive remodelling appear to have more long term success than biomaterials that induce chronic inflammation, fibrosis and encapsulation. In this review we draw upon published animal and human studies to characterize the changes biomaterials undergo after implantation and the typical host responses, placing these in the context of clinical outcomes.
dc.description.indexMEDLINE
dc.description.sponsorshipEPSRC
dc.description.sponsorshipTrust European Marie Curie Network
dc.identifier.citationBIOMED RESEARCH INTERNATIONAL, article ID 968087, 20p, 2015
dc.identifier.doi10.1155/2015/968087
dc.identifier.eissn2314-6141
dc.identifier.issn2314-6133
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/9908
dc.language.isoeng
dc.publisherHINDAWI PUBLISHING CORPORATION
dc.relation.ispartofBiomed Research International
dc.rightsopenAccess
dc.rights.holderCopyright HINDAWI PUBLISHING CORPORATION
dc.subject.othersmall-intestinal submucosa
dc.subject.otherstress urinary-incontinence
dc.subject.otherfree vaginal tape
dc.subject.otherbody-wall repair
dc.subject.othertime-dependent variations
dc.subject.othercadaveric fascia lata
dc.subject.otherquality-of-life
dc.subject.othervivo rat model
dc.subject.otherhost response
dc.subject.otherin-vivo
dc.subject.wosBiotechnology & Applied Microbiology
dc.subject.wosMedicine, Research & Experimental
dc.titleBiomaterials for Pelvic Floor Reconstructive Surgery: How Can We Do Better?
dc.typearticle
dc.type.categoryreview
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryInglaterra
hcfmusp.affiliation.countryisogb
hcfmusp.author.externalGIGLIOBIANCO, Giulia:Univ Sheffield, Mat Sci Engn, Sheffield S1 3JD, S Yorkshire, England
hcfmusp.author.externalREGUEROS, Sabiniano Roman:Univ Sheffield, Mat Sci Engn, Sheffield S1 3JD, S Yorkshire, England
hcfmusp.author.externalOSMAN, Nadir I.:Univ Sheffield, Mat Sci Engn, Sheffield S1 3JD, S Yorkshire, England; Royal Hallamshire Hosp, Sheffield S10 2JF, S Yorkshire, England
hcfmusp.author.externalBULLOCK, Anthony J.:Univ Sheffield, Mat Sci Engn, Sheffield S1 3JD, S Yorkshire, England
hcfmusp.author.externalCHAPPLE, Chris R.:Royal Hallamshire Hosp, Sheffield S10 2JF, S Yorkshire, England
hcfmusp.author.externalMACNEIL, Sheila:Univ Sheffield, Mat Sci Engn, Sheffield S1 3JD, S Yorkshire, England
hcfmusp.citation.scopus50
hcfmusp.contributor.author-fmusphcJULIO CESAR CAMPOS BISSOLI
hcfmusp.description.articlenumber968087
hcfmusp.origemWOS
hcfmusp.origem.pubmed25977927
hcfmusp.origem.scopus2-s2.0-84929353348
hcfmusp.origem.wosWOS:000353823700001
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
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