Vitamin A and Beta-Carotene Concentrations in Adults with HIV/AIDS on Highly Active Antiretroviral Therapy
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | KAIO, Daniella Junko | |
dc.contributor.author | RONDO, Patricia Helen Carvalho | |
dc.contributor.author | SOUZA, Jose Maria Pacheco | |
dc.contributor.author | FIRMINO, Aline Vale | |
dc.contributor.author | LUZIA, Liania Alves | |
dc.contributor.author | SEGURADO, Aluisio Augusto | |
dc.date.accessioned | 2014-04-25T21:51:51Z | |
dc.date.available | 2014-04-25T21:51:51Z | |
dc.date.issued | 2013 | |
dc.description.abstract | Micronutrient deficiency is a common condition in HIV-infected individuals and may occur in all stages of the disease. The objective of this cross-sectional study was to compare the concentrations of vitamin A and beta-carotene, micronutrients related to immunity and oxidative stress, in 182 adults with HIV/AIDS, under different highly active antiretroviral therapy (HAART) regimens. Patients were divided into 3 groups according to their HAART regimen: combination of nucleoside analog reverse transcriptase inhibitors (NRTIs) and non-NRTIs; combination of NRTIs, protease inhibitors, and ritonavir; combination of NRTIs and other classes. Multiple linear regression analysis determined the effect of the treatment regimen, time of use, and compliance with the regimen, on vitamin A and beta-carotene concentrations, controlling for the following variables: gender, age, educational level, smoking, physical activity, body mass index, time of infection with HIV, presence of comorbidities, CD4(+) T lymphocyte count, total cholesterol and fractions, and triglyceride levels. There was no significant difference in vitamin A or beta-carotene concentrations in patients under the different HAART regimens. However, approximately 4% of the patients had deficient/low concentrations of vitamin A (<0.70 mu mol/L), and 98% showed concentrations of beta-carotene <1.0 mu mol/L. In conclusion, HIV/AIDS patients in this region will not benefit from vitamin A supplementation, independently of the HAART regimen utilized, but beta-carotene may be of importance, considering its antioxidant effect. | |
dc.description.index | MEDLINE | |
dc.description.sponsorship | Sao Paulo State Research Foundation-FAPESP, Brazil [2008/56395-5] | |
dc.identifier.citation | JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, v.59, n.6, p.496-502, 2013 | |
dc.identifier.doi | 10.3177/jnsv.59.496 | |
dc.identifier.eissn | 1881-7742 | |
dc.identifier.issn | 0301-4800 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/5130 | |
dc.language.iso | eng | |
dc.publisher | CENTER ACADEMIC PUBL JAPAN | |
dc.relation.ispartof | Journal of Nutritional Science and Vitaminology | |
dc.rights | restrictedAccess | |
dc.rights.holder | Copyright CENTER ACADEMIC PUBL JAPAN | |
dc.subject | HIV infection | |
dc.subject | HAART | |
dc.subject | vitamin A | |
dc.subject | beta-carotene | |
dc.subject | micronutrients | |
dc.subject.other | hiv-infected patients | |
dc.subject.other | micronutrient supplementation | |
dc.subject.other | disease progression | |
dc.subject.other | drug-users | |
dc.subject.other | serum | |
dc.subject.other | deficiency | |
dc.subject.other | retinol | |
dc.subject.other | trial | |
dc.subject.other | atherosclerosis | |
dc.subject.other | association | |
dc.subject.wos | Nutrition & Dietetics | |
dc.title | Vitamin A and Beta-Carotene Concentrations in Adults with HIV/AIDS on Highly Active Antiretroviral Therapy | |
dc.type | article | |
dc.type.category | original article | |
dc.type.version | publishedVersion | |
dspace.entity.type | Publication | |
hcfmusp.author.external | KAIO, Daniella Junko:Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-01246904 Sao Paulo, Brazil | |
hcfmusp.author.external | RONDO, Patricia Helen Carvalho:Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-01246904 Sao Paulo, Brazil | |
hcfmusp.author.external | SOUZA, Jose Maria Pacheco:Univ Sao Paulo, Sch Publ Hlth, Dept Epidemiol, BR-01246904 Sao Paulo, Brazil | |
hcfmusp.author.external | FIRMINO, Aline Vale:Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-01246904 Sao Paulo, Brazil | |
hcfmusp.author.external | LUZIA, Liania Alves:Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-01246904 Sao Paulo, Brazil | |
hcfmusp.citation.scopus | 6 | |
hcfmusp.contributor.author-fmusphc | ALUISIO AUGUSTO COTRIM SEGURADO | |
hcfmusp.description.beginpage | 496 | |
hcfmusp.description.endpage | 502 | |
hcfmusp.description.issue | 6 | |
hcfmusp.description.volume | 59 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.pubmed | 24477245 | |
hcfmusp.origem.scopus | 2-s2.0-84893369359 | |
hcfmusp.origem.wos | WOS:000329383800003 | |
hcfmusp.publisher.city | TOKYO | |
hcfmusp.publisher.country | JAPAN | |
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hcfmusp.remissive.sponsorship | FAPESP | |
hcfmusp.scopus.lastupdate | 2024-05-10 | |
relation.isAuthorOfPublication | 4a19cf96-b472-41a6-a757-f90ecf46ee00 | |
relation.isAuthorOfPublication.latestForDiscovery | 4a19cf96-b472-41a6-a757-f90ecf46ee00 |
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