ENVIRONMENTAL TOBACCO SMOKE INDUCES OXIDATIVE STRESS IN DISTINCT BRAIN REGIONS OF INFANT MICE

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorTORRES, Larissa Helena Lobo
dc.contributor.authorMOREIRA, Wallace Luiz
dc.contributor.authorGARCIA, Raphael Caio Tamborelli
dc.contributor.authorANNONI, Raquel
dc.contributor.authorCARVALHO, Ana Laura Nicoletti
dc.contributor.authorTEIXEIRA, Simone Aparecida
dc.contributor.authorPACHECO-NETO, Maurilio
dc.contributor.authorMUSCARA, Marcelo Nicolas
dc.contributor.authorCAMARINI, Rosana
dc.contributor.authorLOUREIRO, Ana Paula de Melo
dc.contributor.authorYONAMINE, Mauricio
dc.contributor.authorMAUAD, Thais
dc.contributor.authorMARCOURAKIS, Tania
dc.date.accessioned2013-07-30T15:15:04Z
dc.date.available2013-07-30T15:15:04Z
dc.date.issued2012
dc.description.abstractEnvironmental tobacco smoke (ETS) leads to the death of 600,000 nonsmokers annually and is associated with disturbances in antioxidant enzyme capacity in the adult rodent brain. However, little is known regarding the influence of ETS on brain development. The aim of this study was to determine levels of malonaldehyde (MDA) and 3-nitrotyrosine (3-NT), as well as enzymatic antioxidant activities of glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST), and superoxide dismutase (SOD), in distinct brain structures. BALB/c mice were exposed to ETS twice daily for 1 h from postnatal day 5 through postnatal day 18. Acute exposure was performed for 1 h on postnatal day 18. Mice were euthanized either immediately (0) or 3 h after the last exposure. Immediately after an acute exposure there were higher GR and GST activities and MDA levels in the hippocampus, higher GPx and SOD activities in the prefrontal cortex, and higher GST activity and MDA levels in the striatum and cerebellum. Three hours later there was an increase in SOD activity and MDA levels in the hippocampus and a decrease in the activity of all enzymes in the prefrontal cortex. Immediately after final repeated exposure there were elevated levels of GST and GR activity and decreased GPx activity in the hippocampus. Moreover, a rise was found in GPx and GST activities in the prefrontal cortex and increased GST and GPx activity in the striatum and cerebellum, respectively. After 3 h the prefrontal cortex showed elevated GR and GST activities, and the striatum displayed enhanced GST activity. Data showed that enzymatic antioxidant system in the central nervous system responds to ETS differently in different regions of the brain and that a form of adaptation occurs after several days of exposure.
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dc.identifier.citationJOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, v.75, n.16-17, Special Issue, p.971-980, 2012
dc.identifier.doi10.1080/15287394.2012.695985
dc.identifier.issn1528-7394
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/999
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS INC
dc.relation.ispartofJournal of Toxicology and Environmental Health-Part A-current Issues
dc.rightsrestrictedAccess
dc.rights.holderCopyright TAYLOR & FRANCIS INC
dc.subject.otherdismutase transgenic mice
dc.subject.othercigarette-smoke
dc.subject.othersuperoxide-dismutase
dc.subject.otherlipid-peroxidation
dc.subject.otheralzheimers-disease
dc.subject.otherhypoxia-ischemia
dc.subject.othercritical periods
dc.subject.otherbacoside-a
dc.subject.otherrat-brain
dc.subject.otherglutathione
dc.subject.wosEnvironmental Sciences
dc.subject.wosPublic, Environmental & Occupational Health
dc.subject.wosToxicology
dc.titleENVIRONMENTAL TOBACCO SMOKE INDUCES OXIDATIVE STRESS IN DISTINCT BRAIN REGIONS OF INFANT MICE
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalTEIXEIRA, Simone Aparecida:Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, BR-05508900 Sao Paulo, Brazil
hcfmusp.author.externalMUSCARA, Marcelo Nicolas:Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, BR-05508900 Sao Paulo, Brazil
hcfmusp.author.externalCAMARINI, Rosana:Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, BR-05508900 Sao Paulo, Brazil
hcfmusp.author.externalMARCOURAKIS, Tania:Univ Sao Paulo, Fac Ciencias Farmaceut, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, BR-05508900 Sao Paulo, Brazil
hcfmusp.citation.scopus27
hcfmusp.contributor.author-fmusphcRAQUEL ANNONI
hcfmusp.contributor.author-fmusphcANA LAURA NICOLETTI CARVALHO
hcfmusp.contributor.author-fmusphcMAURILIO PACHECO NETO
hcfmusp.contributor.author-fmusphcTHAIS MAUAD
hcfmusp.description.beginpage971
hcfmusp.description.endpage980
hcfmusp.description.issue16-17
hcfmusp.description.issueSpecial Issue
hcfmusp.description.volume75
hcfmusp.lim.ref2012
hcfmusp.origemWOS
hcfmusp.origem.pubmed22852847
hcfmusp.origem.scopus2-s2.0-84864876060
hcfmusp.origem.wosWOS:000307060200004
hcfmusp.publisher.cityPHILADELPHIA
hcfmusp.publisher.countryUSA
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