SERUM VALUES OF ALKALINE PHOSPHATASE AND LACTATE DEHYDROGENASE IN OSTEOSARCOMA

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorZUMARRAGA, Juan Pablo
dc.contributor.authorBAPTISTA, Andre Mathias
dc.contributor.authorROSA, Luis Pablo de La
dc.contributor.authorCAIERO, Marcelo Tadeu
dc.contributor.authorCAMARGO, Olavo Pires de
dc.date.accessioned2016-07-18T12:19:04Z
dc.date.available2016-07-18T12:19:04Z
dc.date.issued2016
dc.description.abstractObjective: To study the relationship between the pre and post chemotherapy (CT) serum levels of alkaline phosphatase (AP) and lactate dehydrogenase (LDH), and the percentage of tumor necrosis (TN) found in specimens after the pre surgical CT in patients with osteosarcoma. Methods: Series of cases with retrospective evaluation of patients diagnosed with osteosarcoma. Participants were divided into two groups according to serum values of both enzymes. The values of AP and LDH were obtained before and after preoperative CT. The percentage of tumor necrosis (TN) of surgical specimens of each patient was also included. Results: One hundred and thirty seven medical records were included from 1990 to 2013. Both the AP as LDH decreased in the patients studied, being the higher in pre CT than post CT. The average LHD decrease was 795.12U/L and AP decrease was 437.40 U/L. The average TN was 34.10 %. There was no statistically significant correlation between the serums values and the percentage of tumoral necrosis. Conclusion: The serum levels values of AP and LDH are not good predictors for the chemotherapy-induced necrosis in patients with osteosarcoma.
dc.description.indexPubMed
dc.identifier.citationACTA ORTOPEDICA BRASILEIRA, v.24, n.3, p.142-146, 2016
dc.identifier.doi10.1590/1413-785220162403157033
dc.identifier.eissn1809-4406
dc.identifier.issn1413-7852
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/14326
dc.language.isoeng
dc.publisherATHA COMUNICACAO & EDITORA
dc.relation.ispartofActa Ortopedica Brasileira
dc.rightsopenAccess
dc.rights.holderCopyright ATHA COMUNICACAO & EDITORA
dc.subjectOsteosarcoma
dc.subjectAlkaline phosphatase
dc.subjectL-Lactate Dehydrogenase
dc.subjectTumor necrosis factors
dc.subjectDrug therapy
dc.subjectPrognosis
dc.subject.otherprognostic-factors
dc.subject.otherosteogenic-sarcoma
dc.subject.otherexperience
dc.subject.otherchemotherapy
dc.subject.wosOrthopedics
dc.titleSERUM VALUES OF ALKALINE PHOSPHATASE AND LACTATE DEHYDROGENASE IN OSTEOSARCOMA
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus12
hcfmusp.contributor.author-fmusphcJUAN PABLO ZUMARRAGA MONTAñO
hcfmusp.contributor.author-fmusphcANDRE MATHIAS BAPTISTA
hcfmusp.contributor.author-fmusphcLUIS PABLO DE LA ROSA MARTINO
hcfmusp.contributor.author-fmusphcMARCELO TADEU CAIERO
hcfmusp.contributor.author-fmusphcOLAVO PIRES DE CAMARGO
hcfmusp.description.beginpage142
hcfmusp.description.beginpage146
hcfmusp.description.issue3
hcfmusp.description.volume24
hcfmusp.origemWOS
hcfmusp.origem.pubmed27217815
hcfmusp.origem.scieloSCIELO:S1413-78522016000300142
hcfmusp.origem.scopus2-s2.0-84970956435
hcfmusp.origem.wosWOS:000376161000005
hcfmusp.publisher.citySAO PAULO SP
hcfmusp.publisher.countryBRAZIL
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Artigos e Materiais de Revistas Científicas - HC/IOT
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