Meningococcal meningitis: clinical and laboratorial characteristics, fatality rate and variables associated with in-hospital mortality

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSTRELOW, Vanessa L.
dc.contributor.authorMIRANDA, Erique Jose F. Peixoto de
dc.contributor.authorKOLBE, Karin R.
dc.contributor.authorFRAMIL, Juliana V. Souza
dc.contributor.authorOLIVEIRA, Augusto Penalva de
dc.contributor.authorVIDAL, Jose E.
dc.date.accessioned2017-02-16T12:56:34Z
dc.date.available2017-02-16T12:56:34Z
dc.date.issued2016
dc.description.abstractMeningococcal meningitis is a public health problem. The aim of this study was to describe the clinical characteristics of patients with meningococcal meningitis, and to identify associated factors with mortality. This was a retrospective study, between 2006 and 2011, at a referral center in Sao Paulo, Brazil. Logistic regression analysis was used to identify factors associated with mortality. We included 316 patients. The median age was 16 years (IQR: 7-27) and 60% were male. The clinical triad: fever, headache and neck stiffness was observed in 89% of the patients. The cerebrospinal triad: pleocytosis, elevated protein levels and low glucose levels was present in 79% of patients. Factors associated with mortality in the multivariate model were age above 50 years, seizures, tachycardia, hypotension and neck stiffness. The classic clinical and laboratory triads of meningococcal meningitis were variable. The fatality rate was low. Age, seizures and shock signs were independently associated with mortality.
dc.description.abstractMeningite meningocócica (MM) é um problema de saúde pública. Os objetivos deste estudo foram descrever características clinicas de pacientes com MM, e identificar fatores associados à mortalidade intra-hospitalar. Trata-se de um estudo retrospectivo, entre 2006 e 2011, em um centro de referência, São Paulo, Brasil. Análise de regressão logística multivariada foi usada para identificar fatores associados na admissão com mortalidade intra-hospitalar. Foram incluídos 316 casos. A média de idade foi 16 anos (IQR: 7–27) e 189 (60%) eram do sexo masculino. A tríade clínica: febre, cefaléia e rigidez de nuca foi observada em 89% dos casos. A tríade do exame de líquor: pleocitose, proteinorraquia elevada e hipoglicorraquia ocorreu em 79% dos casos. Fatores associados à mortalidade no modelo multivariado foram: idade acima de 50 anos, convulsões, taquicardia, hipotensão e rigidez de nuca. Tríades clínicas e laboratoriais clássicas de MM foram variáveis. Na admissão, idade, convulsões, taquicardia e hipotensão associaram-se independentemente com o desfecho.
dc.description.indexMEDLINE
dc.identifier.citationARQUIVOS DE NEURO-PSIQUIATRIA, v.74, n.11, p.875-880, 2016
dc.identifier.doi10.1590/0004-282X20160143
dc.identifier.eissn1678-4227
dc.identifier.issn0004-282X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/18147
dc.language.isoeng
dc.publisherASSOC ARQUIVOS NEURO- PSIQUIATRIA
dc.relation.ispartofArquivos de Neuro-Psiquiatria
dc.rightsopenAccess
dc.rights.holderCopyright ASSOC ARQUIVOS NEURO- PSIQUIATRIA
dc.subjectmeningitis
dc.subjectmeningococcal
dc.subjectNeisseria meningitidis
dc.subjectepidemiology
dc.subjectmeningite meningocócica
dc.subjectNeisseria meningitidis
dc.subjectepidemiologia
dc.subject.otheracquired bacterial-meningitis
dc.subject.otherepidemiology
dc.subject.otherdisease
dc.subject.otheradults
dc.subject.otherbrazil
dc.subject.otherdexamethasone
dc.subject.otherdiagnosis
dc.subject.wosNeurosciences
dc.subject.wosPsychiatry
dc.titleMeningococcal meningitis: clinical and laboratorial characteristics, fatality rate and variables associated with in-hospital mortality
dc.title.alternativeMeningite meningocócica: características clínicas e laboratoriais, taxa de letalidade e variáveis associadas com mortalidade intra-hospitalar
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalSTRELOW, Vanessa L.:Inst Emilio Ribas Doencas Infecciosas, Dept Doencas Infecciosas, Sao Paulo, SP, Brazil
hcfmusp.author.externalKOLBE, Karin R.:Inst Emilio Ribas Doencas Infecciosas, Dept Doencas Infecciosas, Sao Paulo, SP, Brazil
hcfmusp.author.externalFRAMIL, Juliana V. Souza:Inst Emilio Ribas Doencas Infecciosas, Dept Doencas Infecciosas, Sao Paulo, SP, Brazil
hcfmusp.author.externalOLIVEIRA, Augusto Penalva de:Inst Emilio Ribas Doencas Infecciosas, Dept Neurol, Sao Paulo, SP, Brazil
hcfmusp.citation.scopus5
hcfmusp.contributor.author-fmusphcERIQUE JOSE PEIXOTO DE MIRANDA
hcfmusp.contributor.author-fmusphcJOSE ERNESTO VIDAL BERMUDEZ
hcfmusp.description.beginpage875
hcfmusp.description.endpage880
hcfmusp.description.issue11
hcfmusp.description.volume74
hcfmusp.origemWOS
hcfmusp.origem.pubmed27901251
hcfmusp.origem.scieloSCIELO:S0004-282X2016001100875
hcfmusp.origem.scopus2-s2.0-85000730397
hcfmusp.origem.wosWOS:000388579300005
hcfmusp.publisher.citySAO PAULO SP
hcfmusp.publisher.countryBRAZIL
hcfmusp.relation.referenceBarroso DE, 2010, BRAZ J INFECT DIS, V14, P242, DOI 10.1590/S1413-86702010000300008
hcfmusp.relation.referenceBeek D, 2004, NEW ENGL J MED, V351, P1849
hcfmusp.relation.referenceMinisterio da Saude (BR), 2013, SIST INF AGR NOT SIN
hcfmusp.relation.referenceBrouwer MC, 2012, LANCET, V380, P1684, DOI 10.1016/S0140-6736(12)61185-4
hcfmusp.relation.referenceBrouwer MC, 2010, CLIN MICROBIOL REV, V23, P467, DOI 10.1128/CMR.00070-09
hcfmusp.relation.referenceBrust JCM, 2012, NEUROLOGY, V79, P1528, DOI 10.1212/WNL.0b013e31826e7398
hcfmusp.relation.referenceCabellos C, 2009, MEDICINE, V88, P115, DOI 10.1097/MD.0b013e31819d50ef
hcfmusp.relation.referenceChang WN, 2008, INFECTION, V36, P15, DOI 10.1007/s15010-007-7009-8
hcfmusp.relation.referenceCordeiro SM, 2007, T ROY SOC TROP MED H, V101, P1147, DOI 10.1016/j.trstmh.2007.06.012
hcfmusp.relation.referenceDonalisio MRC, 2000, REV SAUDE PUBL, V34, P589, DOI 10.1590/S0034-89102000000600005
hcfmusp.relation.referenceGans J, 2002, NEW ENGL J MED, V347, P1549, DOI 10.1056/NEJMoa021334
hcfmusp.relation.referenceGil-Prieto R, 2011, VACCINE, V29, P5765, DOI 10.1016/j.vaccine.2011.05.089
hcfmusp.relation.referenceGorla MCO, 2011, ENFERM INFEC MICR CL, V29, P85, DOI 10.1016/j.eimc.2010.07.016
hcfmusp.relation.referenceHeckenberg SGB, 2008, MEDICINE, V87, P185, DOI 10.1097/MD.0b013e318180a6b4
hcfmusp.relation.referenceHeckenberg SGB, 2012, NEUROLOGY, V79, P1563, DOI 10.1212/WNL.0b013e31826e2684
hcfmusp.relation.referenceLai WA, 2011, BMC GERIATR, V11, DOI 10.1186/1471-2318-11-91
hcfmusp.relation.referenceOrganizacion Panamericana de la Salud, 2010, INF REG SIREVA 2 201
hcfmusp.relation.referenceSafadi MAP, 2010, NEUROL RES, V32, P263, DOI 10.1179/016164110X12644252260754
hcfmusp.relation.referenceAzevedo LCP, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0064524
hcfmusp.relation.referenceSacchi CT, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020675
hcfmusp.relation.referenceSafadi Marco Aurelio P, 2014, J Pediatric Infect Dis Soc, V3, P91, DOI 10.1093/jpids/piu027
hcfmusp.relation.referenceSantos Magda Levantezi, 2005, Cad. Saúde Pública, V21, P823, DOI 10.1590/S0102-311X2005000300016
hcfmusp.relation.referenceSchut Ewout S, 2008, Pract Neurol, V8, P8, DOI 10.1136/jnnp.2007.139725
hcfmusp.relation.referenceSecretaria de Estado da Saude (SP), 2012, CENTR VIG EP DAD EST
hcfmusp.relation.referenceStephens DS, 2007, LANCET, V369, P2196, DOI 10.1016/S0140-6736(07)61016-2
hcfmusp.relation.referenceTarafdar K, 2001, CLIN INFECT DIS, V33, P406, DOI 10.1086/321885
hcfmusp.relation.referenceThigpen MC, 2011, NEW ENGL J MED, V364, P2016, DOI 10.1056/NEJMoa1005384
hcfmusp.relation.referenceTunkel AR, 2010, MANDELL DOUGLAS BENN, P1189
hcfmusp.relation.referenceVazquez JA, 2007, FEMS MICROBIOL REV, V31, P97, DOI 10.1111/j.1574-6976.2006.00050.x
hcfmusp.relation.referenceZoons E, 2008, NEUROLOGY, V70, P2109, DOI 10.1212/01.wnl.0000288178.91614.5d
hcfmusp.scopus.lastupdate2024-05-17
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