Systemic and Peripheral Mechanisms of Cortical Stimulation-Induced Analgesia and Refractoriness in a Rat Model of Neuropathic Pain

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorASSIS, Danielle V.
dc.contributor.authorCAMPOS, Ana Carolina P.
dc.contributor.authorPASCHOA, Amanda F. N.
dc.contributor.authorSANTOS, Talita F.
dc.contributor.authorFONOFF, Erich T.
dc.contributor.authorPAGANO, Rosana L.
dc.date.accessioned2023-08-16T17:50:19Z
dc.date.available2023-08-16T17:50:19Z
dc.date.issued2023
dc.description.abstractEpidural motor cortex stimulation (MCS) is an effective treatment for refractory neuropathic pain; however, some individuals are unresponsive. In this study, we correlated the effectiveness of MCS and refractoriness with the expression of cytokines, neurotrophins, and nociceptive mediators in the dorsal root ganglion (DRG), sciatic nerve, and plasma of rats with sciatic neuropathy. MCS inhibited hyperalgesia and allodynia in two-thirds of the animals (responsive group), and one-third did not respond (refractory group). Chronic constriction injury (CCI) increased IL-1 fi in the nerve and DRG, inhibited IL-4, IL-10, and IL-17A in the nerve, decreased beta-endorphin, and enhanced substance P in the plasma, compared to the control. Responsive animals showed decreased NGF and increased IL-6 in the nerve, accompanied by restoration of local IL-10 and IL-17A and systemic beta-endorphin. Refractory animals showed increased TNF- alpha and decreased IFN gamma in the nerve, along with decreased TNF- alpha and IL-17A in the DRG, maintaining low levels of systemic beta-endorphin. Our findings suggest that the effectiveness of MCS depends on local control of inflammatory and neurotrophic changes, accompanied by recovery of the opioidergic system observed in neuropathic conditions. So, understanding the refractoriness to MCS may guide an improvement in the efficacy of the technique, thus benefiting patients with persistent neuropathic pain.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshipCoordination for the Improvement of Higher Education Personnel (CAPES) [1409259]
dc.description.sponsorshipHospital Sirio-Libanes
dc.identifier.citationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.24, n.9, article ID 7796, 18p, 2023
dc.identifier.doi10.3390/ijms24097796
dc.identifier.eissn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/54723
dc.language.isoeng
dc.publisherMDPIeng
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.rightsopenAccesseng
dc.rights.holderCopyright MDPIeng
dc.subjectmotor cortex stimulationeng
dc.subjectneuropathic paineng
dc.subjectsciatic nerveeng
dc.subjectinflammationeng
dc.subjectneurotrophinseng
dc.subjectsubstance Peng
dc.subjectbeta-endorphineng
dc.subject.othermotor cortex stimulationeng
dc.subject.otherdorsal-root gangliaeng
dc.subject.otherchronic constriction injuryeng
dc.subject.othersatellite glial-cellseng
dc.subject.otherbeta-endorphineng
dc.subject.othersciatic-nerveeng
dc.subject.otherdynamic regulationeng
dc.subject.othersensory neuronseng
dc.subject.othersubstance-peng
dc.subject.othertnf-alphaeng
dc.subject.wosBiochemistry & Molecular Biologyeng
dc.subject.wosChemistry, Multidisciplinaryeng
dc.titleSystemic and Peripheral Mechanisms of Cortical Stimulation-Induced Analgesia and Refractoriness in a Rat Model of Neuropathic Paineng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalASSIS, Danielle V.:Hosp Sirio Libanes, Lab Neurosci, BR-01308060 Sao Paulo, SP, Brazil
hcfmusp.author.externalCAMPOS, Ana Carolina P.:Hosp Sirio Libanes, Lab Neurosci, BR-01308060 Sao Paulo, SP, Brazil
hcfmusp.author.externalPASCHOA, Amanda F. N.:Hosp Sirio Libanes, Lab Neurosci, BR-01308060 Sao Paulo, SP, Brazil
hcfmusp.author.externalSANTOS, Talita F.:Hosp Sirio Libanes, Lab Neurosci, BR-01308060 Sao Paulo, SP, Brazil
hcfmusp.author.externalPAGANO, Rosana L.:Hosp Sirio Libanes, Lab Neurosci, BR-01308060 Sao Paulo, SP, Brazil
hcfmusp.citation.scopus2
hcfmusp.contributor.author-fmusphcERICH TALAMONI FONOFF
hcfmusp.description.articlenumber7796
hcfmusp.description.issue9
hcfmusp.description.volume24
hcfmusp.origemWOS
hcfmusp.origem.pubmed37175503
hcfmusp.origem.scopus2-s2.0-85159303719
hcfmusp.origem.wosWOS:000987309400001
hcfmusp.publisher.cityBASELeng
hcfmusp.publisher.countrySWITZERLANDeng
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