Protective Effect of N-acetylcysteine on Early Outcomes of Deceased Renal Transplantation

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorDANILOVIC, A.
dc.contributor.authorLUCON, A. M.
dc.contributor.authorSROUGI, M.
dc.contributor.authorSHIMIZU, M. H. M.
dc.contributor.authorIANHEZ, L. E.
dc.contributor.authorNAHAS, W. C.
dc.contributor.authorSEGURO, A. C.
dc.date.accessioned2017-11-27T16:20:43Z
dc.date.available2017-11-27T16:20:43Z
dc.date.issued2011
dc.description.abstractWe investigated the effects of the antioxidant N-acetylcysteine (NAC) on early outcomes of deceased donor renal transplantation. Between April 2005 and June 2008, adult primary graft recipients of deceased renal donors were assigned to treatment (n = 38) or control (n = 36) groups and evaluated for 90 days and one year after renal transplantation. The treatment group received NAC orally (600 mg twice daily) from day 0 to 7 postoperatively. Renal function was determined by serum creatinine, MDRD and Cockcroft-Gault estimated GFR (eGFR), delayed graft function (DGF) and dialysis free Kaplan-Meier estimate curve. Serum levels of thiobarbituric acid reactive substances (TBARS), were employed as markers of oxidative stress. The NAC group displayed a lower mean serum creatinine during the first 90 days (P = .026) and at 1 year after transplantation (P = .005). Furthermore, the NAC group showed a higher mean eGFR throughout the first 90 days and at 1 year. DGF was lower among the NAC group (P = .017) and these recipients required fewer days of dialysis (P = .012). Oxidative stress was significantly attenuated with NAC (P < .001). Our results suggested that NAC enhanced early outcomes of deceased donor renal transplantation by attenuating oxidative stress.
dc.description.indexMEDLINE
dc.description.sponsorshipFAPESP [06/52046-0]
dc.identifier.citationTRANSPLANTATION PROCEEDINGS, v.43, n.5, p.1443-1449, 2011
dc.identifier.doi10.1016/j.transproceed.2011.02.020
dc.identifier.issn0041-1345
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/22496
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofTransplantation Proceedings
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER SCIENCE INC
dc.subject.otherischemia-reperfusion injury
dc.subject.otheracetyl-cysteine
dc.subject.otherkidney-transplantation
dc.subject.otherinduced nephrotoxicity
dc.subject.otherserum creatinine
dc.subject.otherfailure
dc.subject.otherprediction
dc.subject.otherdecrease
dc.subject.otherstress
dc.subject.othermodel
dc.subject.wosImmunology
dc.subject.wosSurgery
dc.subject.wosTransplantation
dc.titleProtective Effect of N-acetylcysteine on Early Outcomes of Deceased Renal Transplantation
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus44
hcfmusp.contributor.author-fmusphcALEXANDRE DANILOVIC
hcfmusp.contributor.author-fmusphcANTONIO MARMO LUCON
hcfmusp.contributor.author-fmusphcMIGUEL SROUGI
hcfmusp.contributor.author-fmusphcMARIA HELOISA MASSOLA SHIMIZU
hcfmusp.contributor.author-fmusphcLUIZ ESTEVAM IANHEZ
hcfmusp.contributor.author-fmusphcWILLIAM CARLOS NAHAS
hcfmusp.contributor.author-fmusphcANTONIO CARLOS SEGURO
hcfmusp.description.beginpage1443
hcfmusp.description.endpage1449
hcfmusp.description.issue5
hcfmusp.description.volume43
hcfmusp.origemWOS
hcfmusp.origem.pubmed21693215
hcfmusp.origem.scopus2-s2.0-79959435104
hcfmusp.origem.wosWOS:000292279800012
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
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