OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY BIOMARKERS AND MICROPERIMETRY FEATURES IN BEHÇET'S UVEITIS

Nenhuma Miniatura disponível
Citações na Scopus
0
Tipo de produção
article
Data de publicação
2023
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
LIPPINCOTT WILLIAMS & WILKINS
Autores
Citação
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, v.43, n.10, p.1680-1690, 2023
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
<bold>Purpose: </bold>To evaluate the parafoveal macular microvasculature and the macular function in patients with retinal vasculitis associated with Beh & ccedil;et's uveitis.<bold>Methods: </bold>In 14 patients with inactive Beh & ccedil;et's uveitis and 26 control individuals (13 with nonocular Beh & ccedil;et's syndrome and 13 healthy subjects), we analyzed the retinal nerve fiber layer, ganglion cell layer, full retinal thickness, foveal avascular zone area and sectorial parafoveal vascular density in the superficial vascular plexus, intermediate capillary plexus, and deep capillary plexus using SPECTRALIS optical coherence tomography (OCT) 2 and OCT angiography. Macular sensitivity was analyzed using an MP-3 microperimeter.<bold>Results: </bold>Eighteen eyes (78%) had a best-corrected visual acuity >= 20/25. Significant differences were found in Beh & ccedil;et's uveitis in comparison with the controls on the OCT and OCT angiography: 14.8%, 22.4%, and 14.9% ganglion cell layer thinning in the global, nasal, and inferior sectors, respectively; 6%, 13.2%, and 7.5% full retinal thickness thinning in the superior, nasal, and inferior sectors; and 16.8%, 14.9%, 23.6%, 15.8%, and 12.6% mean deep capillary plexus density reduction in the global, superior, nasal, inferior, and temporal sectors. Microperimetry data demonstrated significant mean reductions of 21% and 23.6% in central and average macular sensitivities and 28.8%, 40.4%, 27.7%, and 24.2% in the superior, nasal, inferior, and temporal sectors, respectively. Outer plexiform layer elevations were observed in Beh & ccedil;et's uveitis (69.6%).<bold>Conclusion: </bold>Beh & ccedil;et's uveitis presented structural and functional macular damage despite good best-corrected visual acuity, mainly affecting the nasal sector and the deep capillary plexus. On OCT and OCT angiography, quantitative and qualitative changes can be valuable biomarkers of ocular involvement in Beh & ccedil;et's syndrome.
Palavras-chave
Behcet's syndrome, microperimetry, optical coherence tomography angiography, retinal microvasculature
URI
https://observatorio.fm.usp.br/handle/OPI/57661
Referências
  1. Accorinti M, 2020, OCUL IMMUNOL INFLAMM, V28, P589, DOI 10.1080/09273948.2019.1612452
  2. Aksoy FE, 2020, PHOTODIAGN PHOTODYN, V29, DOI 10.1016/j.pdpdt.2019.101646
  3. Atas M., 2014, J Ophthalmol, V2014, P1
  4. Atmaca LS, 2003, BRIT J OPHTHALMOL, V87, P1466, DOI 10.1136/bjo.87.12.1466
  5. Bettiol A, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.02830
  6. Cheng D, 2018, INVEST OPHTH VIS SCI, V59, P1295, DOI 10.1167/iovs.17-23113
  7. Cheng D, 2016, INVEST OPHTH VIS SCI, V57, P5470, DOI 10.1167/iovs.16-19568
  8. COGAN DG, 1984, BRIT J OPHTHALMOL, V68, P10, DOI 10.1136/bjo.68.1.10
  9. Davatchi F, 2014, J EUR ACAD DERMATOL, V28, P338, DOI 10.1111/jdv.12107
  10. Garhofer G, 2012, INVEST OPHTH VIS SCI, V53, P698, DOI 10.1167/iovs.11-8624
  11. Invernizzi A, 2019, CLIN EXP OPHTHALMOL, V47, P357, DOI 10.1111/ceo.13470
  12. Kafieh R, 2015, J OPHTHALMOL, V2015, DOI 10.1155/2015/259123
  13. Khairallah M, 2017, RETINA-J RET VIT DIS, V37, P1678, DOI 10.1097/IAE.0000000000001418
  14. Kido A, 2018, INVEST OPHTH VIS SCI, V59, P2828, DOI 10.1167/iovs.18-24348
  15. Kim AY, 2016, AM J OPHTHALMOL, V171, P101, DOI 10.1016/j.ajo.2016.08.035
  16. Kim M, 2013, INVEST OPHTH VIS SCI, V54, P6033, DOI 10.1167/iovs.13-12231
  17. Nemiroff J, 2016, DEV OPHTHALMOL, V56, P139, DOI 10.1159/000442806
  18. Neves FS, 2007, CLIN RHEUMATOL, V26, P1263, DOI 10.1007/s10067-006-0484-y
  19. Oray M, 2015, AM J OPHTHALMOL, V159, P475, DOI 10.1016/j.ajo.2014.11.029
  20. Pei MH, 2021, OCUL IMMUNOL INFLAMM, V29, P524, DOI 10.1080/09273948.2019.1685108
  21. Raafat KA, 2019, RETINA-J RET VIT DIS, V39, P1607, DOI 10.1097/IAE.0000000000002177
  22. Rohrschneider K, 2008, PROG RETIN EYE RES, V27, P536, DOI 10.1016/j.preteyeres.2008.07.003
  23. Sakane T, 1999, NEW ENGL J MED, V341, P1284, DOI 10.1056/NEJM199910213411707
  24. Smid LM, 2021, INVEST OPHTH VIS SCI, V62, DOI 10.1167/iovs.62.3.8
  25. Spaide RF, 2015, JAMA OPHTHALMOL, V133, P45, DOI 10.1001/jamaophthalmol.2014.3616
  26. Takeuchi M, 2014, OPHTHALMOLOGY, V121, P1877, DOI 10.1016/j.ophtha.2014.04.042
  27. Takeuchi M, 2010, ACTA OPHTHALMOL, V88, P257, DOI 10.1111/j.1755-3768.2009.01536.x
  28. Tugal-Tutkun I, 2004, AM J OPHTHALMOL, V138, P373, DOI 10.1016/j.ajo.2004.03.022
  29. Yan C, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.727151
  30. Yuvaci I, 2019, ARQ BRAS OFTALMOL, V82, P263, DOI 10.5935/0004-2749.20190059

Coleções
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/33