Comparative study and histomorphometric analysis of bone allografts lyophilized and sterilized by autoclaving, gamma irradiation and ethylene oxide in rats

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorALMEIDA, Otavio Machado de
dc.contributor.authorJORGETTI, Wanda
dc.contributor.authorOKSMAN, Denis
dc.contributor.authorJORGETTI, Camilo
dc.contributor.authorROCHA, Diogenes Laercio
dc.contributor.authorGEMPERLI, Rolf
dc.date.accessioned2013-09-23T16:30:06Z
dc.date.available2013-09-23T16:30:06Z
dc.date.issued2013
dc.description.abstractPURPOSE: To compare three sterilization methods (autoclave, gamma irradiation and ethylene oxide) over non demineralized lyophilized bone allografts. METHODS: Bone allografts were implanted on paravertebral muscles of 21 rats. After 30 days animals were sacrificed and grafts underwent comparative analysis regarding histomorphometric and macroscopic parameters. RESULTS: Allografts that underwent the three sterilization methods presents similar weight gain, cortical thickness similar to control group, and less fibrosis than the control group. Grafts that underwent sterilization in autoclave presented less presence of multinucleated giant cells, although not statistically significant. There was also no statistically significant difference regarding mineralization on the three groups. CONCLUSION: The three sterilization methods cause similar effects on bone allografts regarding macroscopic and histomorphometric parameters.
dc.description.indexMEDLINE
dc.identifier.citationACTA CIRURGICA BRASILEIRA, v.28, n.1, p.66-71, 2013
dc.identifier.doi10.1590/S0102-86502013000100011
dc.identifier.issn0102-8650
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/1694
dc.language.isoeng
dc.publisherACTA CIRURGICA BRASILEIRA
dc.relation.ispartofActa Cirurgica Brasileira
dc.rightsopenAccess
dc.rights.holderCopyright ACTA CIRURGICA BRASILEIRA
dc.subjectBone and Bones
dc.subjectHomologous
dc.subjectOsteogenesis
dc.subjectSterilization
dc.subjectRats
dc.subject.othermechanical strength
dc.subject.othertransplantation
dc.subject.otherradiation
dc.subject.otherbanks
dc.subject.wosSurgery
dc.titleComparative study and histomorphometric analysis of bone allografts lyophilized and sterilized by autoclaving, gamma irradiation and ethylene oxide in rats
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalALMEIDA, Otavio Machado de:Antonio Prudente Fdn, Sao Paulo, Brazil
hcfmusp.author.externalOKSMAN, Denis:Hosp Nove Julho, Sao Paulo, Brazil
hcfmusp.author.externalJORGETTI, Camilo:Univ Sao Paulo, Clin Hosp, BR-09500900 Sao Paulo, Brazil
hcfmusp.citation.scopus7
hcfmusp.contributor.author-fmusphcVANDA JORGETTI
hcfmusp.contributor.author-fmusphcDIOGENES LAERCIO ROCHA
hcfmusp.contributor.author-fmusphcROLF GEMPERLI
hcfmusp.description.beginpage66
hcfmusp.description.endpage71
hcfmusp.description.issue1
hcfmusp.description.volume28
hcfmusp.origemWOS
hcfmusp.origem.pubmed23338116
hcfmusp.origem.scieloSCIELO:S0102-86502013000100011
hcfmusp.origem.scopus2-s2.0-84872960395
hcfmusp.origem.wosWOS:000313866600010
hcfmusp.publisher.citySAO PAULO
hcfmusp.publisher.countryBRAZIL
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hcfmusp.scopus.lastupdate2024-04-12
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relation.isAuthorOfPublication121f80ff-64a7-415e-9ec6-80a0902bda87
relation.isAuthorOfPublication.latestForDiscovery43722089-d1f9-4d2c-98df-79d676fb6a5a
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