Neutrophil Gelatinase-Associated Lipocalin Concentration in Vaginal Fluid: Relation to Bacterial Vaginosis and Vulvovaginal Candidiasis

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorBEGHINI, Joziani
dc.contributor.authorGIRALDO, Paulo C.
dc.contributor.authorLINHARES, Iara M.
dc.contributor.authorLEDGER, William J.
dc.contributor.authorWITKIN, Steven S.
dc.date.accessioned2015-10-26T16:51:07Z
dc.date.available2015-10-26T16:51:07Z
dc.date.issued2015
dc.description.abstractObjective: Neutrophil gelatinase-associated lipocalin (NGAL) is a component of innate immunity that prevents iron uptake by microorganisms. We evaluated whether NGAL was present in vaginal fluid and whether concentrations were altered in women with bacterial vaginosis (BV) or vulvovaginal candidiasis (VVC). Methods: Vaginal secretions from 52 women with VVC, 43 with BV, and 77 healthy controls were assayed by enzyme-linked immunosorbent assay for NGAL and for concentrations of l-lactic acid. Results: The median concentration of NGAL in vaginal fluid was significantly higher in control women (561 pg/mL) than in women with BV (402 pg/mL; P = .0116) and lower in women with VVC (741 pg/mL; P = .0017). Median lactic acid levels were similar in controls (0.11 mmol/L) and women with VVC (0.13 mmol/L) and were lower in women with BV (0.02 mmol/L; P < .0001). The NGAL and lactic acid concentrations were highly correlated (P < .0001). Conclusion: A decrease in Lactobacilli and/or lactic acid plus the absence of leukocytes results in lower vaginal NGAL levels that might facilitate the growth of bacteria associated with BV.
dc.description.indexMEDLINE
dc.description.sponsorshipResearch Support Foundation of Sao Paulo (FAPESP) [2011/19960-9]
dc.description.sponsorshipCAPES [4889-13-14]
dc.identifier.citationREPRODUCTIVE SCIENCES, v.22, n.8, p.964-968, 2015
dc.identifier.doi10.1177/1933719115570914
dc.identifier.eissn1933-7205
dc.identifier.issn1933-7191
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/12025
dc.language.isoeng
dc.publisherSAGE PUBLICATIONS INC
dc.relation.ispartofReproductive Sciences
dc.rightsrestrictedAccess
dc.rights.holderCopyright SAGE PUBLICATIONS INC
dc.subjectneutrophil gelatinase-associated lipocalin (NGAL)
dc.subjectbacterial vaginosis
dc.subjectvulvovaginal candidiasis
dc.subjectvaginal fluid
dc.subjectinnate anti-microbial immunity
dc.subject.otherepithelial-cells
dc.subject.otherlactic-acid
dc.subject.otherinfection
dc.subject.otheriron
dc.subject.wosObstetrics & Gynecology
dc.subject.wosReproductive Biology
dc.titleNeutrophil Gelatinase-Associated Lipocalin Concentration in Vaginal Fluid: Relation to Bacterial Vaginosis and Vulvovaginal Candidiasis
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalBEGHINI, Joziani:Weill Cornell Med Coll, Dept Obstet & Gynecol, Div Immunol & Infect Dis, New York, NY 10065 USA; Univ Estadual Campinas, Dept Gynecol & Obstet, Sao Paulo, Brazil
hcfmusp.author.externalGIRALDO, Paulo C.:Univ Estadual Campinas, Dept Gynecol & Obstet, Sao Paulo, Brazil
hcfmusp.author.externalLEDGER, William J.:Weill Cornell Med Coll, Dept Obstet & Gynecol, Div Immunol & Infect Dis, New York, NY 10065 USA
hcfmusp.author.externalWITKIN, Steven S.:Weill Cornell Med Coll, Dept Obstet & Gynecol, Div Immunol & Infect Dis, New York, NY 10065 USA
hcfmusp.citation.scopus30
hcfmusp.contributor.author-fmusphcIARA MORENO LINHARES
hcfmusp.description.beginpage964
hcfmusp.description.endpage968
hcfmusp.description.issue8
hcfmusp.description.volume22
hcfmusp.origemWOS
hcfmusp.origem.pubmed25670719
hcfmusp.origem.scopus2-s2.0-84937538860
hcfmusp.origem.wosWOS:000358076500008
hcfmusp.publisher.cityTHOUSAND OAKS
hcfmusp.publisher.countryUSA
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