Experimental osteoarthritis model by means of medial meniscectomy in rats and effects of diacerein administration and hyaluronic acid injection
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | REZENDE, Marcia Uchao | |
dc.contributor.author | HERNANDEZ, Arnaldo Jose | |
dc.contributor.author | OLIVEIRA, Claudia Regina Gomes Cardim Mendes | |
dc.contributor.author | NETO, Raul Bolliger | |
dc.date.accessioned | 2015-07-01T20:32:07Z | |
dc.date.available | 2015-07-01T20:32:07Z | |
dc.date.issued | 2015 | |
dc.description.abstract | CONTEXT AND OBJECTIVE: The development of a slow and progressive mechanical model for osteoarthritis is important for correlation with clinical practice, and for evaluating the effects of disease-modifying medications. A mechanical osteoarthritis model was developed to evaluate the effects of intra-articular hyaluronic acid (HA) injection and oral diacerein administration. DESIGN AND SETTING: Experimental study at the Department of Orthopedics and Traumatology, Universidade de Sao Paulo. METHOD: Total medial meniscectomy was performed on seven groups of ten Wistar rats each, comprising four control groups (C) and three study groups (S). C.I: operated, non-medicated; C.II: operated, injections of HA vehicle; C.III: non-operated, non-medicated; C.IV: operated, non-medicated, sacrificed three months post-meniscectomy; S.I: operated, receiving intra-articular HA injections; S.II: operated, oral diacerein from the third to the seventh postoperative month; S.III: operated, received both medications. All the animals (except C.IV) were sacrificed seven months post-meniscectomy. All femurs and tibias were assessed histologically. RESULTS: The most severe degenerative histological changes were in the tibias of the operated knees. On the contralateral side, all groups had mild changes on the tibial surface. The femoral surface had slight changes. C.I showed severe changes. S.II results matched those of C.IV. HA protected the tibial surface. S.II and S.III had similar results. CONCLUSIONS: 1) The experimental model produced mild arthritis after three months and severe arthritis after seven months; 2) diacerein reduced the degenerative changes in both knees; 3) HA protected the joint cartilage; 4) Combining the two drugs did not improve the results. | |
dc.description.abstract | CONTEXTO E OBJETIVO: Desenvolver um modelo osteoartrítico mecânico lento e progressivo é importante para correlação com a prática clínica e para avaliar os efeitos de medicamentos modificadores da doença. Um modelo mecânico de osteartrite foi desenvolvido para avaliar os efeitos de injeção intra-articular de hialuronato de sódio (AH) e de administração de diacereína oral. DESENHO E LOCAL: Estudo experimental no Departamento de Ortopedia e Traumatologia, Universidade de São Paulo. MÉTODO: Meniscectomia medial total foi feita em sete grupos de dez ratos Wistar, sendo quatro grupos controle (C) e três grupos estudo (E). C.I: operado, não medicado; C.II: operado, recebendo injeções do veículo do AH; C.III: não operado, não medicado; C.IV: operado, não medicado, sacrificado três meses pósmeniscectomia; EI: operado, recebendo injeções de AH intra-articular; E.II: operado, recebendo diacereína oral do terceiro ao sétimo mês pós-operatório; E.III: operado, recebeu ambas medicações. Todos os animais (exceto C.IV) foram sacrificados sete meses pós-meniscectomia. Todos os fêmures e tíbias foram analisados histologicamente. RESULTADOS: As alterações histológicas degenerativas mais graves encontram-se nas tíbias dos joelhos operados. No lado contra-lateral, todos os grupos apresentaram alterações leves na superfície tibial. A superfície femoral teve ligeiras alterações. C.I apresentou alterações graves. S.II equiparou seus resultados aos do grupo C.IV. AH protegeu a superfície tibial. S.II e S.III apresentaram resultados semelhantes. CONCLUSÕES: 1) O modelo experimental gerou artrite leve aos três e grave aos sete meses; 2) Diacereína reduziu as alterações degenerativas de ambos os joelhos; 3) AH protege a cartilagem articular; 4) A associação dos dois fármacos não melhora os resultados. | |
dc.description.index | MEDLINE | |
dc.identifier.citation | SAO PAULO MEDICAL JOURNAL, v.133, n.1, p.4-12, 2015 | |
dc.identifier.doi | 10.1590/1516-3180.2013.6730001 | |
dc.identifier.issn | 1516-3180 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/9425 | |
dc.language.iso | eng | |
dc.publisher | ASSOCIACAO PAULISTA MEDICINA | |
dc.relation.ispartof | Sao Paulo Medical Journal | |
dc.rights | openAccess | |
dc.rights.holder | Copyright ASSOCIACAO PAULISTA MEDICINA | |
dc.subject | Osteoarthritis | |
dc.subject | Knee | |
dc.subject | Anthraquinones | |
dc.subject | Hyaluronic acid | |
dc.subject | Models, animal | |
dc.subject | Osteoartrite | |
dc.subject | Joelho | |
dc.subject | Antraquinonas | |
dc.subject | Ácido hialurônico | |
dc.subject | Modelos animais | |
dc.subject.other | weight sodium hyaluronate | |
dc.subject.other | knee-joint | |
dc.subject.other | rabbit knee | |
dc.subject.other | cartilage | |
dc.subject.other | expression | |
dc.subject.other | drugs | |
dc.subject.other | hyalgan(r) | |
dc.subject.other | resection | |
dc.subject.other | lesions | |
dc.subject.other | sheep | |
dc.subject.wos | Medicine, General & Internal | |
dc.title | Experimental osteoarthritis model by means of medial meniscectomy in rats and effects of diacerein administration and hyaluronic acid injection | |
dc.title.alternative | Modelo experimental de osteoartrite através da meniscectomia medial em ratos e efeitos da administração de diacereína e da injeção de ácido hialurônico | |
dc.type | article | |
dc.type.category | original article | |
dc.type.version | publishedVersion | |
dspace.entity.type | Publication | |
hcfmusp.citation.scopus | 9 | |
hcfmusp.contributor.author-fmusphc | MARCIA UCHOA DE REZENDE | |
hcfmusp.contributor.author-fmusphc | ARNALDO JOSE HERNANDEZ | |
hcfmusp.contributor.author-fmusphc | CLAUDIA REGINA GOMES CARDIM MENDES DE OLIVEIRA | |
hcfmusp.contributor.author-fmusphc | RAUL BOLLIGER NETO | |
hcfmusp.description.beginpage | 4 | |
hcfmusp.description.endpage | 12 | |
hcfmusp.description.issue | 1 | |
hcfmusp.description.volume | 133 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.pubmed | 25424775 | |
hcfmusp.origem.scielo | SCIELO:S1516-31802015000100004 | |
hcfmusp.origem.scopus | 2-s2.0-84937511152 | |
hcfmusp.origem.wos | WOS:000348200200002 | |
hcfmusp.publisher.city | SAO PAULO | |
hcfmusp.publisher.country | BRAZIL | |
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hcfmusp.scopus.lastupdate | 2024-05-10 | |
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