Physical exercise attenuates obesity development in Western-diet fed obese rats independently of vitamin D supplementation

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCORDEIRO, Maiara Mikuska
dc.contributor.authorRIBEIRO, Rosane Aparecida
dc.contributor.authorBUBNA, Patricia Biscaia
dc.contributor.authorALMEIDA, Any Caroline de
dc.contributor.authorLAGINSKI, Thiago Rentz Ferreira
dc.contributor.authorFRANCO, Gilson Cesar Nobre
dc.contributor.authorSCOMPARIN, Dionizia Xavier
dc.date.accessioned2022-06-20T15:32:27Z
dc.date.available2022-06-20T15:32:27Z
dc.date.issued2022
dc.description.abstractPhysical inactivity, associated with the ingestion of hypercaloric foods, contributes to obesity development. In contrast, physical exercise training (ET) can slow obesity progression. Vitamin (Vit) D, a hormone that regulates adipocyte metabolism, may represent a strategy to reduce obesity; however, it is currently not known whether Vit D enhances the anti-obesity benefits of physical exercise. We hypothesized that swimming ET may prevent Western diet (WD)-induced obesity, and that Vit D supplementation could enhance the anti-obesity actions of ET. Male Wistar rats were fed, from 21 to 90 days of age, on a standard diet, or a WD, in association or not (sedentary control [CTL-SED] and WD [WD-SED] groups) with swimming ET for 15 min/day, 3 days a week (exercised CTL [CTL-EXE] and WD [WD-EXE] groups). Additionally, at 60 days of age, half of the CTL-EXE and WD-EXE groups were submitted, or not, to oral Vit D supplementation (CTL-EXE-VD and WD-EXE-VD groups, respectively). At 91 days old, WD-SED rats displayed increased body weight, abdominal adiposity, hypercholesterolemia, hyperleptinaemia and high circulating levels of tumour necrosis factor (TNF)-alpha. Swimming ET attenuated the increase in abdominal adiposity induced by WD. Furthermore, the WD-EXE group exhibited reductions in glycaemia, triglyceridaemia, cholesterolaemia, leptinaemia and in plasma TNF-alpha concentrations. Vitamin D supplementation, combined with ET, did not provide any additive benefit against adiposity, only potentiating the effects of ET action on the reduction in triglyceridaemia. Exercise training, independently of Vit D, provides a strategy to attenuate the adiposity expansion that is induced by WD, mediated in part by reductions in leptinaemia and TNF-alpha levels.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipCoordenac~ao de Aperfeicoamento de Pessoal de Nivel Superior [001]
dc.identifier.citationCLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, v.49, n.6, p.633-642, 2022
dc.identifier.doi10.1111/1440-1681.13637
dc.identifier.eissn1440-1681
dc.identifier.issn0305-1870
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/47285
dc.language.isoeng
dc.publisherWILEYeng
dc.relation.ispartofClinical and Experimental Pharmacology and Physiology
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright WILEYeng
dc.subjectadipokineseng
dc.subjectcholecalciferoleng
dc.subjectexercise trainingeng
dc.subjectobesityeng
dc.subjectswimmingeng
dc.subjectWestern dieteng
dc.subject.otheradipose-tissueeng
dc.subject.othercafeteria dieteng
dc.subject.otherleptin receptoreng
dc.subject.otherserum leptineng
dc.subject.otherglucoseeng
dc.subject.otherresistanceeng
dc.subject.otherstorageeng
dc.subject.otherlivereng
dc.subject.wosRheumatologyeng
dc.titlePhysical exercise attenuates obesity development in Western-diet fed obese rats independently of vitamin D supplementationeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalCORDEIRO, Maiara Mikuska:Univ Estadual Ponta Grossa, Gen Biol Dept, Biol Sci & Hlth Sect, Ponta Grossa, Parana, Brazil
hcfmusp.author.externalRIBEIRO, Rosane Aparecida:Univ Estadual Ponta Grossa, Gen Biol Dept, Biol Sci & Hlth Sect, Ponta Grossa, Parana, Brazil
hcfmusp.author.externalBUBNA, Patricia Biscaia:Univ Estadual Ponta Grossa, Gen Biol Dept, Biol Sci & Hlth Sect, Ponta Grossa, Parana, Brazil
hcfmusp.author.externalALMEIDA, Any Caroline de:Univ Estadual Ponta Grossa, Gen Biol Dept, Biol Sci & Hlth Sect, Ponta Grossa, Parana, Brazil
hcfmusp.author.externalFRANCO, Gilson Cesar Nobre:Univ Estadual Ponta Grossa, Gen Biol Dept, Biol Sci & Hlth Sect, Ponta Grossa, Parana, Brazil
hcfmusp.author.externalSCOMPARIN, Dionizia Xavier:Univ Estadual Ponta Grossa, Gen Biol Dept, Biol Sci & Hlth Sect, Ponta Grossa, Parana, Brazil
hcfmusp.citation.scopus1
hcfmusp.contributor.author-fmusphcTHIAGO RENTZ FERREIRA LAGINSKI
hcfmusp.description.beginpage633
hcfmusp.description.endpage642
hcfmusp.description.issue6
hcfmusp.description.volume49
hcfmusp.origemWOS
hcfmusp.origem.pubmed35271745
hcfmusp.origem.scopus2-s2.0-85128386400
hcfmusp.origem.wosWOS:000784041300001
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hcfmusp.publisher.countryUSAeng
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