Factors associated with pain pressure threshold in both local and remote sites in knee osteoarthritis

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Tipo de produção
article
Data de publicação
2024
DOI
Scopus
Web of Science
PubMed
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ISSN da Revista
Título do Volume
Editora
WILEY
Autores
REBELLO-SANCHEZ, Ingrid
PARENTE, Joao
MARDUY, Anna
VASQUEZ-AVILA, Karen
PACHECO-BARRIOS, Kevin
CASTELO-BRANCO, Luis
FREGNI, Felipe
Citação
PM&R, v.16, n.2, p.132-140, 2024
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: Knee osteoarthritis (KOA) is a prevalent condition, and its most frequent symptom is pain that often leads to disability. Pain sensitization is a core feature of KOA, and it can be measured through quantitative sensory testing protocols such as pain pressure threshold (PPT). However, there is a lack of understanding about the factors that may influence changes in PPTs in the KOA population.Objective: To explore the clinical and functional factors associated with PPTs in a sample of people with chronic KOA pain and to compare models of local (knees) and remote (thenar regions) sites.Design: Cross-sectional analysis of a prospective cohort.Setting: Primary care in public institution.Participants: 113 adults with KOA.Intervention: N/A.Main Outcome MeasuresMultivariable regression analyses evaluating demographic, clinical, and functional variables that could be associated with local and remote PPTs (main outcomes) were performed.Results: Both thenar region (adjusted-R-2: 0.29) and knee (adjusted-R-2: 0.45) models had the same significant negative association with being a female, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain levels (thenar: beta: -0.15, p = .002; knee: beta: -0.2, p < .001), and the 10-Meter Walking Test (thenar: beta: -0.05, p = .038; knee: beta: -0.08, p = .004). A small significant positive association with depressive symptoms was identified in both models, which acted as a confounder for WOMAC pain and was likely affected by unmeasured confounders.Conclusions: PPTs in KOA pain are associated with functional outcomes such as the 10-Meter Walking Test and activity-related pain intensity; thus more disability is associated with smaller pain thresholds. Similarity between models may suggest central sensitization.
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URI
https://observatorio.fm.usp.br/handle/OPI/58900
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MLS