Evaluation of the diaphragm muscle remodeling, inflammation, oxidative stress and vascularization in smokers: An autopsy study

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorNUCCI, R.A.B.
dc.contributor.authorMAIFRINO, L.B.M.
dc.contributor.authorBUSSE, A.L.
dc.contributor.authorSOUZA, R.R. De
dc.contributor.authorPASQUALUCCI, C.A.
dc.contributor.authorANARUMA, C.A.
dc.contributor.authorLEITE, R.E.P.
dc.contributor.authorRODRIGUEZ, R.D.
dc.contributor.authorSUEMOTO, C.K.
dc.contributor.authorJACOB-FILHO, W.
dc.date.accessioned2021-04-29T12:56:16Z
dc.date.available2021-04-29T12:56:16Z
dc.date.issued2020
dc.description.abstractBackground/Aims: Cigarette smoking is a key factor in systemic inflammation and oxidative stress, and it has also been associated with the loss of muscle strength and an elevated risk of pulmonary diseases. Thus, this study aimed to analyze the effects of cigarette smoking on the diaphragm muscle structure of postmortem samples. Methods: Immunohistochemical techniques were used for muscle remodeling (metalloproteinases 2 and 9), inflammation (cyclooxygenase-2), oxidative stress (8-hydroxy-2'-deoxyguanosine), and vascularization (vascular endothelial growth factor). Hematoxylin and eosin stain was used for histopathological analysis and Picrosirius stain was used to highlight the collagen fibers. Results: Cigarette smokers had an increase of diaphragm muscle remodeling, oxidative stress, inflammation, and vascularization compared to non-smokers. Conclusion: Diaphragm muscle structure may be negatively affected by cigarette smoking. © 2020 The Author(s).eng
dc.description.indexMEDLINEeng
dc.identifier.citationCELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v.54, n.4, p.567-576, 2020
dc.identifier.doi10.33594/000000240
dc.identifier.issn1015-8987
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/40219
dc.language.isoeng
dc.publisherCELL PHYSIOL BIOCHEM PRESS GMBH & CO KGeng
dc.relation.ispartofCellular Physiology and Biochemistry
dc.rightsopenAccesseng
dc.rights.holderCopyright CELL PHYSIOL BIOCHEM PRESS GMBH & CO KGeng
dc.subjectAutopsy studyeng
dc.subjectCigarette smokeeng
dc.subjectDiaphragm muscleeng
dc.subjectHistopathological analysiseng
dc.subject.other8 hydroxydeoxyguanosineeng
dc.subject.othercyclooxygenase 2eng
dc.subject.otherdyeeng
dc.subject.othereosineng
dc.subject.othergelatinase aeng
dc.subject.othergelatinase beng
dc.subject.otherhematoxylineng
dc.subject.otherpicrosiriuseng
dc.subject.otherunclassified drugeng
dc.subject.othervasculotropineng
dc.subject.othercyclooxygenase 2eng
dc.subject.othergelatinase aeng
dc.subject.othergelatinase beng
dc.subject.othervasculotropin aeng
dc.subject.otheradulteng
dc.subject.otherarticleeng
dc.subject.otherautopsyeng
dc.subject.othercigarette smokingeng
dc.subject.otherclinical studyeng
dc.subject.othercollagen fibereng
dc.subject.othercontrolled studyeng
dc.subject.othercross-sectional studyeng
dc.subject.otherdiaphragm diseaseeng
dc.subject.otherfemaleeng
dc.subject.otherhistopathologyeng
dc.subject.otherhumaneng
dc.subject.otherhuman tissueeng
dc.subject.otherimmunohistochemistryeng
dc.subject.otherinflammationeng
dc.subject.othermaleeng
dc.subject.othermiddle agedeng
dc.subject.otheroxidative stresseng
dc.subject.otherpriority journaleng
dc.subject.otherrespiratory tract disease assessmenteng
dc.subject.otherstainingeng
dc.subject.othervascularizationeng
dc.subject.otheragedeng
dc.subject.otherdiaphragmeng
dc.subject.othervery elderlyeng
dc.subject.otheradverse eventeng
dc.subject.othercigarette smokingeng
dc.subject.otherdiaphragmeng
dc.subject.otherdrug effecteng
dc.subject.otherinflammationeng
dc.subject.othermetabolismeng
dc.subject.otheroxidative stresseng
dc.subject.otherpathologyeng
dc.subject.othersmokingeng
dc.subject.other8-hydroxy-2'-deoxyguanosineeng
dc.subject.otheragedeng
dc.subject.otheraged, 80 and overeng
dc.subject.otherautopsyeng
dc.subject.othercigarette smokingeng
dc.subject.othercross-sectional studieseng
dc.subject.othercyclooxygenase 2eng
dc.subject.otherdiaphragmeng
dc.subject.otherfemaleeng
dc.subject.otherhumanseng
dc.subject.otherinflammationeng
dc.subject.othermaleeng
dc.subject.othermatrix metalloproteinase 2eng
dc.subject.othermatrix metalloproteinase 9eng
dc.subject.othermiddle agedeng
dc.subject.otheroxidative stresseng
dc.subject.othersmokerseng
dc.subject.othervascular endothelial growth factor aeng
dc.titleEvaluation of the diaphragm muscle remodeling, inflammation, oxidative stress and vascularization in smokers: An autopsy studyeng
dc.typearticleeng
dc.type.categoryeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalMAIFRINO, L.B.M.:Laboratory of Morphological and Immunohistochemical Studies, São Judas Tadeu University, São Paulo, Brazil
hcfmusp.author.externalSOUZA, R.R. De:Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil, Department of Anatomy, 9 de Julho University (UNINOVE), São Paulo, Brazil
hcfmusp.author.externalANARUMA, C.A.:Laboratory of Morphology and Physical Activity, Department of Physical Education, São Paulo State University 'Júlio de Mesquita Filho', Rio Claro, Brazil
hcfmusp.citation.scopus2
hcfmusp.contributor.author-fmusphcRICARDO APARECIDO BAPTISTA NUCCI
hcfmusp.contributor.author-fmusphcALEXANDRE LEOPOLD BUSSE
hcfmusp.contributor.author-fmusphcCARLOS AUGUSTO GONCALVES PASQUALUCCI
hcfmusp.contributor.author-fmusphcRENATA ELAINE PARAIZO LEITE
hcfmusp.contributor.author-fmusphcROBERTA DIEHL RODRIGUEZ
hcfmusp.contributor.author-fmusphcCLAUDIA KIMIE SUEMOTO
hcfmusp.contributor.author-fmusphcWILSON JACOB FILHO
hcfmusp.description.beginpage567
hcfmusp.description.endpage576
hcfmusp.description.issue4
hcfmusp.description.volume54
hcfmusp.origemSCOPUS
hcfmusp.origem.pubmed32496722
hcfmusp.origem.scopus2-s2.0-85086052052
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