Pro-inflammatory mediators in vaginal fluid and short cervical length in pregnancy

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSISTI, G.
dc.contributor.authorPACCOSI, S.
dc.contributor.authorPARENTI, A.
dc.contributor.authorSERAVALLI, V
dc.contributor.authorLINARI, C.
dc.contributor.authorTOMMASO, M. Di
dc.contributor.authorWITKIN, S.
dc.date.accessioned2020-06-01T15:08:48Z
dc.date.available2020-06-01T15:08:48Z
dc.date.issued2020
dc.description.abstractAIM: We hypothesized that elevated vaginal levels of matrix metalloproteinase-8 (MMP-8), interleukin-8 (IL-8) and the 70kDa heat shock protein (hsp70), compounds involved in inflammatory responses, correlated with a short cervix in pregnant women. METHODS: This prospective cohort study used a convenience sample of 64 women in their early third trimester with a singleton pregnancy. A short cervical length was present in 35 women (54.7 %). Vaginal fluid was tested for levels of MMP-8, IL-8 and hsp70 by enzyme-linked immunosorbent assay (ELISA). A receiver operating charasteristic (ROC) analysis was used to calculate the area under the curve (AUC) for each mediator in predicting short cervical length. RESULTS: MMP-8 (109 vs 29.6 ng/ml, p=0.014), IL-8 (689 vs 330 pg/ml, p=0.007) and hsp70 (4.4 vs 2.9 ng/ml, p=0.036) were all elevated in vaginal samples from women with a short cervix. In addition, there was a negative association between the concentration of each compound in vaginal fluid and cervical length p <= 0.026). The vaginal IL-8 concentration had the highest negative correlation with a short cervix (AUC=0.7, p=0.007). CONCLUSION: MMP-8, hsp70 and IL-8 contribute to a pro-inflammatory cervico-vaginal milieu that weakens cervical integrity and leads to a shortening in cervical length (Tab. 4, Fig. 1, Ref. 27). Text in PDF www.elis.sk.eng
dc.description.indexMEDLINEeng
dc.identifier.citationBRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, v.121, n.4, p.278-281, 2020
dc.identifier.doi10.4149/BLL_2020_042
dc.identifier.eissn1336-0345
dc.identifier.issn0006-9248
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/36317
dc.language.isoeng
dc.publisherCOMENIUS UNIVeng
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright COMENIUS UNIVeng
dc.subjectcervical lengtheng
dc.subjectheat shock proteineng
dc.subjectinterleukin-8eng
dc.subjectmatrix metalloproteinase-8eng
dc.subjectvaginal fluideng
dc.subject.otherpreterm deliveryeng
dc.subject.othermatrix metalloproteinase-8eng
dc.subject.othercytokine levelseng
dc.subject.otherheat-shock-protein-70eng
dc.subject.otherexpressioneng
dc.subject.otherproliferationeng
dc.subject.otherassociationeng
dc.subject.othercleavageeng
dc.subject.otherserumeng
dc.subject.othertermeng
dc.subject.wosMedicine, General & Internaleng
dc.titlePro-inflammatory mediators in vaginal fluid and short cervical length in pregnancyeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryItália
hcfmusp.affiliation.countryisoit
hcfmusp.affiliation.countryisous
hcfmusp.author.externalSISTI, G.:Lincoln Med & Mental Hlth Ctr, Dept Obstet & Gynecol, 234 East 149th St 5th Floor, Bronx, NY 10451 USA
hcfmusp.author.externalPACCOSI, S.:Lincoln Med & Mental Hlth Ctr, Dept Obstet & Gynecol, 234 East 149th St 5th Floor, Bronx, NY 10451 USA; Univ Florence, Dept Hlth Sci, Florence, Italy
hcfmusp.author.externalPARENTI, A.:Lincoln Med & Mental Hlth Ctr, Dept Obstet & Gynecol, 234 East 149th St 5th Floor, Bronx, NY 10451 USA; Univ Florence, Dept Hlth Sci, Florence, Italy
hcfmusp.author.externalSERAVALLI, V:Lincoln Med & Mental Hlth Ctr, Dept Obstet & Gynecol, 234 East 149th St 5th Floor, Bronx, NY 10451 USA; Univ Florence, Dept Hlth Sci, Florence, Italy
hcfmusp.author.externalLINARI, C.:Lincoln Med & Mental Hlth Ctr, Dept Obstet & Gynecol, 234 East 149th St 5th Floor, Bronx, NY 10451 USA; Univ Florence, Dept Hlth Sci, Florence, Italy
hcfmusp.author.externalTOMMASO, M. Di:Lincoln Med & Mental Hlth Ctr, Dept Obstet & Gynecol, 234 East 149th St 5th Floor, Bronx, NY 10451 USA; Univ Florence, Dept Hlth Sci, Florence, Italy
hcfmusp.citation.scopus5
hcfmusp.contributor.author-fmusphcSTEVEN SOL WITKIN
hcfmusp.description.beginpage278
hcfmusp.description.endpage281
hcfmusp.description.issue4
hcfmusp.description.volume121
hcfmusp.origemWOS
hcfmusp.origem.pubmed32356442
hcfmusp.origem.scopus2-s2.0-85087051437
hcfmusp.origem.wosWOS:000530579700005
hcfmusp.publisher.cityBRATISLAVA Ieng
hcfmusp.publisher.countrySLOVAKIAeng
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