Assessment of bone metabolism biomarkers in serum and saliva of cirrhotic patients

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorTENORIO, Jefferson Rocha
dc.contributor.authorDUARTE, Nathalia Tuany
dc.contributor.authorANDRADE, Natalia Silva
dc.contributor.authorBERGAMINI, Mariana Lobo
dc.contributor.authorMAMANA, Ana Carolina
dc.contributor.authorBRAZ-SILVA, Paulo Henrique
dc.contributor.authorORTEGA, Karem L.
dc.date.accessioned2022-04-19T13:13:49Z
dc.date.available2022-04-19T13:13:49Z
dc.date.issued2022
dc.description.abstractObjective To assess the serum and salivary levels of biomarkers related to bone metabolism in cirrhotic patients as well as the evidence of osteoporotic changes on panoramic radiographs. Materials and methods Thirty-eight cirrhotic patients underwent anamnesis and physical examination. Specimens of blood and saliva were collected for evaluation by using Luminex (TM) xMAP technology to quantify RANKL, OPG, IL-1 beta, IL-6 and TNF-alpha. Panoramic radiographs were evaluated based on the mandibular cortical index (MCI) and the resulting data were compared to the expression of biomarkers in serum and saliva. Descriptive data analysis was performed and the Mann-Whitney's test and Spearman's correlation were used. Results Most of the sample consisted of males (68.4%) who had cirrhosis mostly resulting from alcoholism (28.9%). Median concentration values of RANKL (74.44 pg/mL), IL-1 beta (45.91 pg/mL), IL-6 (67.69 pg/mL) and TNF-alpha (5.97 pg/mL) in saliva were higher than those observed in serum. In 72.7% of the panoramic radiographs, MCI was found to be suggestive of osteoporotic changes. No statistically significant correlation was observed between salivary and serum expressions of biomarkers or between biomarkers and MCI. Conclusion RANKL, OPG, IL-1 beta, IL-6 and TNF-alpha are expressed differently in serum and saliva and the concentration of these biomarkers is not related to MCI.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipBrazilian National Council for Scientific and Technological Development (CNPq grant)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ)Fundacao de Apoio a Pesquisa do Distrito Federal (FAPDF) [44004/2014-5]
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP grant)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2015/07727]
dc.description.sponsorshipCoordination for the Improvement of Higher Education Personnel (CAPES)Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001]
dc.identifier.citationCLINICAL ORAL INVESTIGATIONS, v.26, n.2, p.1861-1868, 2022
dc.identifier.doi10.1007/s00784-021-04161-7
dc.identifier.eissn1436-3771
dc.identifier.issn1432-6981
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/46294
dc.language.isoeng
dc.publisherSPRINGER HEIDELBERGeng
dc.relation.ispartofClinical Oral Investigations
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright SPRINGER HEIDELBERGeng
dc.subjectHepatic cirrhosiseng
dc.subjectOsteoporosiseng
dc.subjectBone biomarkerseng
dc.subjectSalivaeng
dc.subjectPanoramic radiographyeng
dc.subject.otherpanoramic radiographic findingseng
dc.subject.otherbiochemical markerseng
dc.subject.otherimmune dysfunctioneng
dc.subject.othermineral densityeng
dc.subject.otherosteoporosiseng
dc.subject.othersystemeng
dc.subject.otherrankleng
dc.subject.otherdiagnosiseng
dc.subject.otherdiseaseeng
dc.subject.othermasseng
dc.subject.wosDentistry, Oral Surgery & Medicineeng
dc.titleAssessment of bone metabolism biomarkers in serum and saliva of cirrhotic patientseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalTENORIO, Jefferson Rocha:Univ Sao Paulo, Sch Dent, Dept Stomatol, Av Prof Lineu Prestes 2227, BR-05508900 Sao Paulo, SP, Brazil
hcfmusp.author.externalDUARTE, Nathalia Tuany:Univ Sao Paulo, Sch Dent, Dept Stomatol, Av Prof Lineu Prestes 2227, BR-05508900 Sao Paulo, SP, Brazil
hcfmusp.author.externalANDRADE, Natalia Silva:Univ Sao Paulo, Sch Dent, Dept Stomatol, Av Prof Lineu Prestes 2227, BR-05508900 Sao Paulo, SP, Brazil; Univ Fed Sergipe, Dept Dent, Lagarto, Sergipe, Brazil
hcfmusp.author.externalBERGAMINI, Mariana Lobo:Univ Sao Paulo, Sch Dent, Dept Stomatol, Av Prof Lineu Prestes 2227, BR-05508900 Sao Paulo, SP, Brazil
hcfmusp.author.externalORTEGA, Karem L.:Univ Sao Paulo, Sch Dent, Dept Stomatol, Av Prof Lineu Prestes 2227, BR-05508900 Sao Paulo, SP, Brazil
hcfmusp.citation.scopus1
hcfmusp.contributor.author-fmusphcANA CAROLINA MAMANA FERNANDES DE SOUZA
hcfmusp.contributor.author-fmusphcPAULO HENRIQUE BRAZ DA SILVA
hcfmusp.description.beginpage1861
hcfmusp.description.endpage1868
hcfmusp.description.issue2
hcfmusp.description.volume26
hcfmusp.origemWOS
hcfmusp.origem.pubmed34491448
hcfmusp.origem.scopus2-s2.0-85114289752
hcfmusp.origem.wosWOS:000695350100002
hcfmusp.publisher.cityHEIDELBERGeng
hcfmusp.publisher.countryGERMANYeng
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