Substantia nigra fractional anisotropy is not a diagnostic biomarker of Parkinson's disease: A diagnostic performance study and meta-analysis

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Arquivos
art_HIRATA_Substantia_nigra_fractional_anisotropy_is_not_a_diagnostic_2017.PDF (855.71 KB)
Citações na Scopus
24
Tipo de produção
article
Data de publicação
2017
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER
Autores
VIEIRA, Gilson
Citação
EUROPEAN RADIOLOGY, v.27, n.6, p.2640-2648, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objectives Our goal was to estimate the diagnostic accuracy of substantia nigra fractional anisotropy (SN-FA) for Parkinson's disease (PD) diagnosis in a sample similar to the clinical setting, including patients with essential tremor (ET) and healthy controls (HC). We also performed a systematic review and meta-analysis to estimate mean change in SN-FA induced by PD and its diagnostic accuracy. Methods Our sample consisted of 135 subjects: 72 PD, 21 ET and 42 HC. To address inter-scanner variability, two 3.0-T MRI scans were performed. MRI results of this sample were pooled into a meta-analysis that included 1,432 subjects (806 PD and 626 HC). A bivariate model was used to evaluate diagnostic accuracy measures. Results In our sample, we did not observe a significant effect of disease on SN-FA and it was uninformative for diagnosis. The results of the meta-analysis estimated a 0.03 decrease in mean SN-FA in PD relative to HC (CI: 0.01-0.05). However, the discriminatory capability of SN-FA to diagnose PD was low: pooled sensitivity and specificity were 72 % (CI: 68-75) and 63 % (CI: 58-70), respectively. There was high heterogeneity between studies (I-2 = 91.9%). Conclusions SN-FAcannot be used as an isolatedmeasure to diagnose PD.
Palavras-chave
Parkinson's disease/Parkinsonism, Essential tremor, Magnetic resonance imaging (MRI), Diffusion-weighted imaging (DWI), Sensitivity and specificity
URI
https://observatorio.fm.usp.br/handle/OPI/20010
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MDR
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