Parathyroid Hormone: A Uremic Toxin

Imagem de Miniatura
Arquivos
art_DUQUE_Parathyroid_Hormone_A_Uremic_Toxin_2020.PDF (1.48 MB)
Citações na Scopus
29
Tipo de produção
article
Data de publicação
2020
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
MDPI
Autores
Citação
TOXINS, v.12, n.3, article ID 189, 16p, 2020
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Parathyroid hormone (PTH) has an important role in the maintenance of serum calcium levels. It activates renal 1 alpha-hydroxylase and increases the synthesis of the active form of vitamin D (1,25[OH](2)D-3). PTH promotes calcium release from the bone and enhances tubular calcium resorption through direct action on these sites. Hallmarks of secondary hyperparathyroidism associated with chronic kidney disease (CKD) include increase in serum fibroblast growth factor 23 (FGF-23), reduction in renal 1,25[OH](2)D-3 production with a decline in its serum levels, decrease in intestinal calcium absorption, and, at later stages, hyperphosphatemia and high levels of PTH. In this paper, we aim to critically discuss severe CKD-related hyperparathyroidism, in which PTH, through calcium-dependent and -independent mechanisms, leads to harmful effects and manifestations of the uremic syndrome, such as bone loss, skin and soft tissue calcification, cardiomyopathy, immunodeficiency, impairment of erythropoiesis, increase of energy expenditure, and muscle weakness.
Palavras-chave
parathyroid hormone, secondary hyperparathyroidism, uremic toxin
URI
https://observatorio.fm.usp.br/handle/OPI/36178
Referências
  1. Adey D, 2000, AM J PHYSIOL-ENDOC M, V278, pE219
  2. Ahamed NAHS, 2008, J TAIBAH UNIV MED SC, V3, P44
  3. AMANN K, 1994, J AM SOC NEPHROL, V4, P1814
  4. AMEND WJC, 1975, J LAB CLIN MED, V86, P435
  5. Araujo MJCLN, 2016, BONE, V91, P75, DOI 10.1016/j.bone.2016.07.009
  6. BACZYNSKI R, 1985, KIDNEY INT, V28, P722, DOI 10.1038/ki.1985.190
  7. Baron R, 2007, ENDOCRINOLOGY, V148, P2635, DOI 10.1210/en.2007-0270
  8. Baron R, 2013, NAT MED, V19, P179, DOI 10.1038/nm.3074
  9. Blaine J, 2015, CLIN J AM SOC NEPHRO, V10, P1257, DOI 10.2215/CJN.09750913
  10. Boltenstal H, 2019, CALCIFIED TISSUE INT, V104, P214, DOI 10.1007/s00223-018-0491-4
  11. BONEWALD LF, 1994, J CELL BIOCHEM, V55, P350, DOI 10.1002/jcb.240550312
  12. BRICKMAN AS, 1974, ARCH INTERN MED, V134, P883
  13. Centeno PP, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-12399-9
  14. Chou FF, 2001, ARCH SURG-CHICAGO, V136, P1064, DOI 10.1001/archsurg.136.9.1064
  15. Chou FF, 2008, SURGERY, V143, P526, DOI 10.1016/j.surg.2007.11.019
  16. Coco M, 2000, AM J KIDNEY DIS, V36, P1115, DOI 10.1053/ajkd.2000.19812
  17. Conigrave AD, 2016, FRONT PHYSIOL, V7, DOI 10.3389/fphys.2016.00563
  18. Cuppari L, 2004, J AM SOC NEPHROL, V15, P2933, DOI 10.1097/01.ASN.0000141961.49723.BC
  19. Custodio MR, 2012, NEPHROL DIAL TRANSPL, V27, P1437, DOI 10.1093/ndt/gfr447
  20. Da JJ, 2015, AM J KIDNEY DIS, V66, P258, DOI 10.1053/j.ajkd.2015.01.009
  21. Danese MD, 2006, AM J KIDNEY DIS, V47, P149, DOI 10.1053/j.ajkd.2005.09.024
  22. Denda M, 1996, AM J KIDNEY DIS, V28, P596, DOI 10.1016/S0272-6386(96)90473-4
  23. Duan YB, 1999, J CLIN ENDOCR METAB, V84, P718, DOI 10.1210/jc.84.2.718
  24. Eknoyan G, 2003, AM J KIDNEY DIS, V41, pS1, DOI 10.1016/S0272-6386(03)00111-2
  25. FADDA GZ, 1988, KIDNEY INT, V33, P1066, DOI 10.1038/ki.1988.112
  26. Faul C, 2011, J CLIN INVEST, V121, P4393, DOI 10.1172/JCI46122
  27. Filvaroff E, 1999, DEVELOPMENT, V126, P4267
  28. FRASER CL, 1985, J CLIN INVEST, V76, P1789, DOI 10.1172/JCI112170
  29. Fukagawa M, 2001, AM J KIDNEY DIS, V38, pS152, DOI 10.1053/ajkd.2001.27426
  30. Fulzele K, 2010, CELL, V142, P309, DOI 10.1016/j.cell.2010.06.002
  31. Goldenstein PT, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0198946
  32. Goldenstein PT, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0068870
  33. GOMEZFERNANDEZ P, 1984, MED CLIN-BARCELONA, V82, P395
  34. Goodman WG, 2002, NEPHROL DIAL TRANSPL, V17, P1731, DOI 10.1093/ndt/17.10.1731
  35. Goto S, 2010, THER APHER DIAL, V14, P417, DOI 10.1111/j.1744-9987.2010.00813.x
  36. Graciolli FG, 2017, KIDNEY INT, V91, P1436, DOI 10.1016/j.kint.2016.12.029
  37. GUISADO R, 1975, J CLIN INVEST, V55, P738, DOI 10.1172/JCI107984
  38. Gutierrez OM, 2009, CIRCULATION, V119, P2545, DOI 10.1161/CIRCULATIONAHA.108.844506
  39. Heyliger A, 2009, SURGERY, V146, P1042, DOI 10.1016/j.surg.2009.09.024
  40. Hofbauer LC, 2007, OSTEOPOROSIS INT, V18, P251, DOI 10.1007/s00198-006-0282-z
  41. Hofbauer LC, 2000, J BONE MINER RES, V15, P2, DOI 10.1359/jbmr.2000.15.1.2
  42. Hory BG, 2000, J ENDOCRINOL INVEST, V23, P273, DOI 10.1007/BF03343723
  43. Hu MC, 2011, J AM SOC NEPHROL, V22, P124, DOI 10.1681/ASN.2009121311
  44. Huntgeburth M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026628
  45. Iimori S, 2012, NEPHROL DIAL TRANSPL, V27, P345, DOI 10.1093/ndt/gfr317
  46. Iwasaki-Ishizuka Y, 2005, NEPHROL DIAL TRANSPL, V20, P1904, DOI 10.1093/ndt/gfh876
  47. Jansz T.T., 2019, OSTEOPOROSIS INT, P1, DOI [10.1093/ndt/gfz096.FC023, DOI 10.1093/NDT/GFZ096.FC023]
  48. Jiang X, 1998, RENAL FAILURE, V20, P135, DOI 10.3109/08860229809045096
  49. Jilka RL, 2007, BONE, V40, P1434, DOI 10.1016/j.bone.2007.03.017
  50. Jorde R, 2005, J HYPERTENS, V23, P1639, DOI 10.1097/01.hjh.0000179764.40701.36
  51. Jorde R, 2000, HYPERTENSION, V35, P1154, DOI 10.1161/01.HYP.35.5.1154
  52. Khajehdehi P, 1999, J Ren Nutr, V9, P186, DOI 10.1016/S1051-2276(99)90032-8
  53. Kir S, 2016, CELL METAB, V23, P315, DOI 10.1016/j.cmet.2015.11.003
  54. KLINGER M, 1990, KIDNEY INT, V37, P1543, DOI 10.1038/ki.1990.147
  55. Lanske B, 1999, J CLIN INVEST, V104, P399, DOI 10.1172/JCI6629
  56. Lee YJ, 2020, J BONE MINER RES, V35, P317, DOI 10.1002/jbmr.3893
  57. Leiba A, 2013, J HUM HYPERTENS, V27, P399, DOI 10.1038/jhh.2012.49
  58. LEVI J, 1987, CLIN BIOCHEM, V20, P121, DOI 10.1016/S0009-9120(87)80110-8
  59. Linefsky JP, 2011, J AM COLL CARDIOL, V58, P291, DOI 10.1016/j.jacc.2010.11.073
  60. Lishmanov A, 2012, INT UROL NEPHROL, V44, P541, DOI 10.1007/s11255-010-9897-2
  61. Lourida I, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0127574
  62. Mace ML, 2017, KIDNEY INT, V92, P165, DOI 10.1016/j.kint.2017.01.015
  63. Mak R H, 1983, Kidney Int Suppl, V16, pS128
  64. MAK RHK, 1992, KIDNEY INT, V41, P1049, DOI 10.1038/ki.1992.159
  65. Mandolfo S, 1998, NEPHROL DIAL TRANSPL, V13, P2708, DOI 10.1093/ndt/13.10.2708
  66. Manolagas SC, 2000, ENDOCR REV, V21, P115, DOI 10.1210/er.21.2.115
  67. Martin A, 2012, PHYSIOL REV, V92, P131, DOI 10.1152/physrev.00002.2011
  68. McCarthy JT, 2016, MAYO CLIN PROC, V91, P1384, DOI 10.1016/j.mayocp.2016.06.025
  69. MEYTES D, 1981, J CLIN INVEST, V67, P1263, DOI 10.1172/JCI110154
  70. Moe SM, 2014, J BONE MINER RES, V29, P902, DOI 10.1002/jbmr.2089
  71. Molina P, 2017, J CACHEXIA SARCOPENI, V8, P686, DOI 10.1002/jcsm.12218
  72. Murer H, 2003, ANNU REV PHYSIOL, V65, P531, DOI 10.1146/annurev.physiol.65.042902.092424
  73. NAVEHMANY T, 1995, J CLIN INVEST, V96, P1786, DOI 10.1172/JCI118224
  74. Neves KR, 2007, KIDNEY INT, V71, P1262, DOI 10.1038/sj.ki.5002241
  75. Neves KR, 2004, KIDNEY INT, V66, P2237, DOI 10.1111/j.1523-1755.2004.66013.x
  76. Nickolas TL, 2013, J BONE MINER RES, V28, P1811, DOI 10.1002/jbmr.1916
  77. Nickolas TL, 2011, J AM SOC NEPHROL, V22, P1560, DOI 10.1681/ASN.2010121275
  78. Nigwekar SU, 2016, J AM SOC NEPHROL, V27, P3421, DOI 10.1681/ASN.2015091065
  79. NODA M, 1989, ENDOCRINOLOGY, V124, P2991, DOI 10.1210/endo-124-6-2991
  80. Olauson H, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003975
  81. Parfitt AM, 1996, ANN INTERN MED, V125, P413, DOI 10.7326/0003-4819-125-5-199609010-00009
  82. Pettway GJ, 2005, BONE, V36, P959, DOI 10.1016/j.bone.2005.02.015
  83. Picton ML, 2000, KIDNEY INT, V58, P1440, DOI 10.1046/j.1523-1755.2000.00306.x
  84. Qiu T, 2010, NAT CELL BIOL, V12, P224, DOI 10.1038/ncb2022
  85. Rashid G, 2009, AM J PHYSIOL-RENAL, V296, pF60, DOI 10.1152/ajprenal.00622.2007
  86. RITZ E, 1995, AM J KIDNEY DIS, V26, P808, DOI 10.1016/0272-6386(95)90448-4
  87. Saleh FN, 2003, EUR HEART J, V24, P2054, DOI 10.1016/j.ehj.2003.09.010
  88. Santos FRL, 2003, KIDNEY INT, V63, P899, DOI 10.1046/j.1523-1755.2003.00835.x
  89. Schluter KD, 1998, CARDIOVASC RES, V37, P34, DOI 10.1016/S0008-6363(97)00194-6
  90. Schumock GT, 2009, NEPHRON CLIN PRACT, V113, pC54, DOI 10.1159/000228076
  91. Shao JS, 2003, J BIOL CHEM, V278, P50195, DOI 10.1074/jbc.M308825200
  92. Silver J, 2013, NAT REV NEPHROL, V9, P641, DOI 10.1038/nrneph.2013.147
  93. Tentori F, 2008, AM J KIDNEY DIS, V52, P519, DOI 10.1053/j.ajkd.2008.03.020
  94. Wolf G, 2008, NUTR REV, V66, P229, DOI 10.1111/j.1753-4887.2008.00027.x
  95. Workeneh BT, 2010, AM J CLIN NUTR, V91, p1128S, DOI 10.3945/ajcn.2010.28608B
  96. Yasunaga C, 1999, AM J SURG, V178, P332, DOI 10.1016/S0002-9610(99)00194-4
  97. Zhang Y, 2018, CLIN CHIM ACTA, V482, P40, DOI 10.1016/j.cca.2018.03.028

Coleções
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/16
Artigos e Materiais de Revistas Científicas - ODS/03