Widespread pesticide contamination of drinking water and impact on cancer risk in Brazil

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorPANIS, Carolina
dc.contributor.authorCANDIOTTO, Luciano Zanetti Pessoa
dc.contributor.authorGABOARDI, Shaiane Carla
dc.contributor.authorGURZENDA, Susie
dc.contributor.authorCRUZ, Jurandir
dc.contributor.authorCASTRO, Marcia
dc.contributor.authorLEMOS, Bernardo
dc.date.accessioned2022-10-26T14:41:25Z
dc.date.available2022-10-26T14:41:25Z
dc.date.issued2022
dc.description.abstractPesticides, which are associated with endocrine dysfunction, immunological dysregulation, and cancer, are widespread sources of drinking water contamination. The state of Parana has a population of 11 million, is the second largest grain producer in Brazil and is a leading consumer of pesticides. In this study, we analyzed the extent of drinking water contamination from 11 proven, probable, or potentially carcinogenic pesticides (alachlor, aldrin-dieldrin, atrazine, chlordane, DDT-DDD-DDE, diuron, glyphosate-AMPA, lindane-gamma-HCH, mancozeb-ETU, molinate, and trifluralin) in 127 grain-producing municipalities in the state of Parana. Extensive contamination of drinking water was found, including legacy pesticides such as aldrin-dieldrin (mean 0.047 ppb), DDT-DDD-DDE (mean: 0.07), chlordane (mean: 0.181), and lindane-HCH (mean: 2.17). Most of the municipalities were significantly above the maximum limits for each one of the currently allowed pesticides (67% for alachlor, 9.44% for atrazine, 96.85% for diuron, 100% for glyphosate-AMPA, 80.31% for mancozeb-ETU, 91.33% for molinate, and 12.6% for trifluralin). Ninety-seven percent of municipalities presented a sum of all pesticides at levels significantly above (189.84 ppb) the European Union preconized limits (<0.5 ppb). Using the mean pesticide concentration in water (ppb), the exposed population for each municipality, and the benchmark cancer risk for pesticides, we estimated the minimum number of cancer cases attributable to pesticide-contaminated drinking water during the period (total of 542 cases). More than 80% were attributed to mancozeb-ETU and diuron. Glyphosate-AMPA and diuron-attributable cases strongly correlated with the total cancer cases in the same period (R = 0.8117 and 0.8138, respectively) as well as with breast cancer cases (R = 0.7695 and 0.7551, respectively). Water contamination was significantly correlated with the sum of the estimated cancer cases for all 11 pesticides detected in each city (R = 0.58 and p < 0.0001). These findings reveal extensive contamination of drinking water in the state of Parana and suggest that contamination may increase the risk of cancer in this region.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipLemann Foundation Fellowship
dc.description.sponsorshipConselho Nacional de Desemvolvimento Cientifico e Tecnologico [18/2021, 4/2021]
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [01/2019]
dc.description.sponsorship[5R01ES027981]
dc.identifier.citationENVIRONMENT INTERNATIONAL, v.165, article ID 107321, 11p, 2022
dc.identifier.doi10.1016/j.envint.2022.107321
dc.identifier.eissn1873-6750
dc.identifier.issn0160-4120
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/49411
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDeng
dc.relation.ispartofEnvironment International
dc.rightsopenAccesseng
dc.rights.holderCopyright PERGAMON-ELSEVIER SCIENCE LTDeng
dc.subjectDrinking watereng
dc.subjectPesticideseng
dc.subjectContaminationeng
dc.subjectCancereng
dc.subject.otherorganochlorine pesticideseng
dc.subject.otherglyphosate useeng
dc.subject.othersurface-watereng
dc.subject.otherbreast-cancereng
dc.subject.otherhalf-lifeeng
dc.subject.otheratrazineeng
dc.subject.otherwomeneng
dc.subject.othermancozebeng
dc.subject.otherassociationseng
dc.subject.othergroundwatereng
dc.subject.wosEnvironmental Scienceseng
dc.titleWidespread pesticide contamination of drinking water and impact on cancer risk in Brazileng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalPANIS, Carolina:State Univ Western Parana, Lab Tumor Biol, UNIOESTE, Francisco Beltrao, Parana, Brazil; Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA
hcfmusp.author.externalCANDIOTTO, Luciano Zanetti Pessoa:State Univ Western Parana, UNIOESTE, Terr Studies Grp GETERR, Francisco Beltrao, Parana, Brazil
hcfmusp.author.externalGABOARDI, Shaiane Carla:Catarinense Fed Inst Sci & Technol, Campus Ibirama, Ibirama, SC, Brazil
hcfmusp.author.externalGURZENDA, Susie:Harvard TH Chan Sch Publ Hlth, Dept Global Hlth & Populat, Boston, MA USA
hcfmusp.author.externalCASTRO, Marcia:Harvard TH Chan Sch Publ Hlth, Dept Global Hlth & Populat, Boston, MA USA
hcfmusp.author.externalLEMOS, Bernardo:Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA
hcfmusp.citation.scopus58
hcfmusp.contributor.author-fmusphcJURANDIR BATISTA DA CRUZ JUNIOR
hcfmusp.description.articlenumber107321
hcfmusp.description.volume165
hcfmusp.origemWOS
hcfmusp.origem.pubmed35691095
hcfmusp.origem.scopus2-s2.0-85131686389
hcfmusp.origem.wosWOS:000832982000006
hcfmusp.publisher.cityOXFORDeng
hcfmusp.publisher.countryENGLANDeng
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