Maternal Hypercholesterolemia Associated with Nicotine Exposure in Adulthood May Induce Kidney Injury in Male Rats if Hypomagnesemia Occurs

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorHELOU, Claudia M. B.
dc.contributor.authorVOLPINI, Rildo A.
dc.contributor.authorSANTINHO, Mirela A. R.
dc.contributor.authorFONSECA, Fabricio L.
dc.contributor.authorSIMIAO, Andre L.
dc.date.accessioned2018-03-06T15:21:17Z
dc.date.available2018-03-06T15:21:17Z
dc.date.issued2017
dc.description.abstractBackground/Aims: Maternal hypercholesterolemia is a risk factor to renal injury in rat pups at adulthood, especially if they feed a cholesterol-enriched diet after weaning. However, the renal function of male pups of dams with hypercholesterolemia (PH) that were fed a regular chow from weaning to adulthood needs investigation, particularly those exposed to an adverse risk such as nicotine. Methods: We evaluated the renal function of PH animals and we compared the data with those found in male pups of control dams (PC) at 3- and 6-month-old by inulin clearance. Moreover, we investigated the effect of nicotine treatment for 8 days in both PH and PC animals at 6 months old via metabolic function studies and by renal histological analysis. Results: Inulin clearance and other renal function parameters were similar in PH and PC animals at 3 and 6 months old. Nevertheless, the PH group showed significant differences with regard to histological analysis despite a similar number of glomeruli. The glomerular area of PH animals was significantly smaller than that measured in PC animals, and the fractional interstitial area was significantly larger in PH animals than that measured in PC animals at 3 months old. With regard to nicotine treatment, we observed a trend for a reduction in creatinine clearance in both PC and PH groups, but only PH animals showed hypomagnesemia and the highest fractional interstitial area. Conclusions: The offspring exposed to a high cholesterol milieu during intrauterine and neonatal life may show a silent kidney injury at adulthood that may be aggravated by nicotine exposure if hypomagnesemia occurs. (c) 2017 The Author(s) Published by S. Karger AG, Basel
dc.description.indexMEDLINE
dc.description.sponsorshipLaboratorio de Investigacao Medica - HCFMUSP
dc.description.sponsorshipFundacao Faculdade Medicina (FFM)
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2010/52294-0]
dc.description.sponsorshipFAPESP [2004/02449-6]
dc.identifier.citationKIDNEY & BLOOD PRESSURE RESEARCH, v.42, n.6, p.974-982, 2017
dc.identifier.doi10.1159/000485343
dc.identifier.eissn1423-0143
dc.identifier.issn1420-4096
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/25764
dc.language.isoeng
dc.publisherKARGER
dc.relation.ispartofKidney & Blood Pressure Research
dc.rightsopenAccess
dc.rights.holderCopyright KARGER
dc.subjectFetal programming
dc.subjectHypercholesterolemia
dc.subjectHypomagnesemia
dc.subjectKidney injury
dc.subjectNicotine
dc.subjectRenal function
dc.subject.othermagnesium-deficiency
dc.subject.otheroxidative stress
dc.subject.otherblood-pressure
dc.subject.otherrenal-function
dc.subject.otherdisease
dc.subject.otheratherosclerosis
dc.subject.otherpregnancy
dc.subject.otherphenotype
dc.subject.otherweight
dc.subject.othertrpm7
dc.subject.wosPhysiology
dc.subject.wosUrology & Nephrology
dc.subject.wosPeripheral Vascular Disease
dc.titleMaternal Hypercholesterolemia Associated with Nicotine Exposure in Adulthood May Induce Kidney Injury in Male Rats if Hypomagnesemia Occurs
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalSIMIAO, Andre L.:Univ Sao Paulo, Fac Med, Hosp Clin, Lab Pesquisa Basica LIM 12,Nefrol, Sao Paulo, SP, Brazil
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcCLAUDIA MARIA DE BARROS HELOU
hcfmusp.contributor.author-fmusphcRILDO APARECIDO VOLPINI
hcfmusp.contributor.author-fmusphcMIRELA APARECIDA RODRIGUES SANTINHO
hcfmusp.contributor.author-fmusphcFABRICIO LOPES DA FONSECA
hcfmusp.description.beginpage974
hcfmusp.description.endpage982
hcfmusp.description.issue6
hcfmusp.description.volume42
hcfmusp.origemWOS
hcfmusp.origem.pubmed29179203
hcfmusp.origem.scopus2-s2.0-85035752352
hcfmusp.origem.wosWOS:000423291800003
hcfmusp.publisher.cityBASEL
hcfmusp.publisher.countrySWITZERLAND
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