Active vs. reactive threat responding is associated with differential c-Fos expression in specific regions of amygdala and prefrontal cortex

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMARTINEZ, Raquel C. R.
dc.contributor.authorGUPTA, Nikita
dc.contributor.authorLAZARO-MUNOZ, Gabriel
dc.contributor.authorSEARS, Robert M.
dc.contributor.authorKIM, Soojeong
dc.contributor.authorMOSCARELLO, Justin M.
dc.contributor.authorLEDOUX, Joseph E.
dc.contributor.authorCAIN, Christopher K.
dc.date.accessioned2014-01-28T22:27:27Z
dc.date.available2014-01-28T22:27:27Z
dc.date.issued2013
dc.description.abstractActive avoidance (AA) is an important paradigm for studying mechanisms of aversive instrumental learning, pathological anxiety, and active coping. Unfortunately, AA neurocircuits are poorly understood, partly because behavior is highly variable and reflects a competition between Pavlovian reactions and instrumental actions. Here we exploited the behavioral differences between good and poor avoiders to elucidate the AA neurocircuit. Rats received Sidman AA training and expression of the activity-dependent immediate-early gene c-fos was measured after a shock-free AA test. Six brain regions with known or putative roles in AA were evaluated: amygdala, periaqueductal gray, nucleus accumbens, dorsal striatum, prefrontal cortex (PFC), and hippocampus. Good avoiders showed little Pavlovian freezing and high AA rates at test, the opposite of poor avoiders. Although c-Fos activation was observed throughout the brain, differential activation was found only in subregions of amygdala and PFC. Interestingly, c-Fos correlated with avoidance and freezing in only five of 20 distinct areas evaluated: lateral amygdala, central amygdala, medial amygdala, basal amygdala, and infralimbic PFC. Thus, activity in specific amygdala-PFC circuits likely mediates the competition between instrumental actions and Pavlovian reactions after AA training. Individual differences in AA behavior, long considered a nuisance by researchers, may be the key to elucidating the AA neurocircuit and understanding pathological response profiles.
dc.description.indexMEDLINE
dc.description.sponsorshipNational Institute of Mental Health (NIH-NIMH) [R01 MH38774, R21 MH097125, NRSA MH077458, F31MH086294-01A1, F32MH094061]
dc.description.sponsorshipNSF [0920153]
dc.description.sponsorshipNational Institute on Drug Abuse (NIH-NIDA) [R01 DA029053, F6761-01]
dc.description.sponsorshipCAPES [2350/09-2]
dc.description.sponsorshipFAPESP [11/08575-7, 12/06825-9]
dc.identifier.citationLEARNING & MEMORY, v.20, n.8, p.446-452, 2013
dc.identifier.doi10.1101/lm.031047.113
dc.identifier.issn1072-0502
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/4304
dc.language.isoeng
dc.publisherCOLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
dc.relation.ispartofLearning & Memory
dc.rightsrestrictedAccess
dc.rights.holderCopyright COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
dc.subject.otherconditioned fear
dc.subject.otherlateral amygdala
dc.subject.othercontextual fear
dc.subject.otherbasal amygdala
dc.subject.otheravoidance
dc.subject.otherextinction
dc.subject.otherrat
dc.subject.otheracquisition
dc.subject.othernuclei
dc.subject.otherhippocampus
dc.subject.wosNeurosciences
dc.subject.wosPsychology, Experimental
dc.titleActive vs. reactive threat responding is associated with differential c-Fos expression in specific regions of amygdala and prefrontal cortex
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalGUPTA, Nikita:NYU, Ctr Neural Sci, New York, NY 10003 USA
hcfmusp.author.externalLAZARO-MUNOZ, Gabriel:NYU, Ctr Neural Sci, New York, NY 10003 USA
hcfmusp.author.externalSEARS, Robert M.:NYU, Ctr Neural Sci, New York, NY 10003 USA
hcfmusp.author.externalKIM, Soojeong:Nathan S Kline Inst Psychiat Res, Emot Brain Inst, Orangeburg, NY 10962 USA
hcfmusp.author.externalMOSCARELLO, Justin M.:NYU, Ctr Neural Sci, New York, NY 10003 USA
hcfmusp.author.externalLEDOUX, Joseph E.:NYU, Ctr Neural Sci, New York, NY 10003 USA; Nathan S Kline Inst Psychiat Res, Emot Brain Inst, Orangeburg, NY 10962 USA
hcfmusp.author.externalCAIN, Christopher K.:NYU, Ctr Neural Sci, New York, NY 10003 USA; Nathan S Kline Inst Psychiat Res, Emot Brain Inst, Orangeburg, NY 10962 USA
hcfmusp.citation.scopus72
hcfmusp.contributor.author-fmusphcRAQUEL CHACON RUIZ MARTINEZ
hcfmusp.description.beginpage446
hcfmusp.description.endpage452
hcfmusp.description.issue8
hcfmusp.description.volume2013
hcfmusp.origemWOS
hcfmusp.origem.pubmed23869027
hcfmusp.origem.scopus2-s2.0-84881108717
hcfmusp.origem.wosWOS:000323316300008
hcfmusp.publisher.cityCOLD SPRING HARBOR
hcfmusp.publisher.countryUSA
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