Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorPEZATO, Rogerio
dc.contributor.authorBALSALOBRE, Leonardo
dc.contributor.authorLIMA, Milena
dc.contributor.authorBEZERRA, Thiago F. P.
dc.contributor.authorVOEGELS, Richard L.
dc.contributor.authorGREGORIO, Luis Carlos
dc.contributor.authorSTAMM, Aldo Cassol
dc.contributor.authorZELE, Thibaut van
dc.date.accessioned2014-01-28T22:24:58Z
dc.date.available2014-01-28T22:24:58Z
dc.date.issued2013
dc.description.abstractThis review is addressed two pathophysiologic mechanisms implicated in the pathogenesis of nasal polyposis: the unique remodeling process found in nasal polyp tissue and the immune response of patients with nasal polyposis to Staphylococcus aureus. These two theories converge to the same direction in different aspects, including decreased extracellular matrix production, impaired T regulation and favoring of a Th2 immune response. In patients with nasal polyposis, an exaggerated immune response to Staphylococcus aureus may aggravate the airway remodeling process.
dc.description.indexMEDLINE
dc.identifier.citationJOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, v.42, article ID 27, 5p, 2013
dc.identifier.doi10.1186/1916-0216-42-27
dc.identifier.issn1916-0216
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/4123
dc.language.isoeng
dc.publisherBIOMED CENTRAL LTD
dc.relation.ispartofJournal of Otolaryngology-Head & Neck Surgery
dc.rightsopenAccess
dc.rights.holderCopyright BIOMED CENTRAL LTD
dc.subjectAirway remodeling
dc.subjectSuperantigens
dc.subjectNasal polyps
dc.subject.othergrowth-factor-beta
dc.subject.otherchronic rhinosinusitis
dc.subject.othertgf-beta
dc.subject.othermatrix metalloproteinases
dc.subject.othertissue inhibitor
dc.subject.otherige
dc.subject.otherenterotoxins
dc.subject.otherexpression
dc.subject.othercells
dc.subject.otherdifferentiation
dc.subject.wosOtorhinolaryngology
dc.titleConvergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling
dc.typearticle
dc.type.categoryreview
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryBélgica
hcfmusp.affiliation.countryisobe
hcfmusp.author.externalPEZATO, Rogerio:Univ Fed Sao Paulo, Dept Otolaryngol Head & Neck Surg, BR-02526060 Sao Paulo, Brazil; Univ Ghent, Dept Otorhinolaryngol, Ghent Univ Hosp, B-9000 Ghent, Belgium
hcfmusp.author.externalBALSALOBRE, Leonardo:Univ Fed Sao Paulo, Dept Otolaryngol Head & Neck Surg, BR-02526060 Sao Paulo, Brazil
hcfmusp.author.externalLIMA, Milena:Mil Police Hosp, Sao Paulo, Brazil
hcfmusp.author.externalGREGORIO, Luis Carlos:Univ Fed Sao Paulo, Dept Otolaryngol Head & Neck Surg, BR-02526060 Sao Paulo, Brazil
hcfmusp.author.externalSTAMM, Aldo Cassol:Univ Fed Sao Paulo, Dept Otolaryngol Head & Neck Surg, BR-02526060 Sao Paulo, Brazil
hcfmusp.author.externalZELE, Thibaut van:Univ Ghent, Dept Otorhinolaryngol, Ghent Univ Hosp, B-9000 Ghent, Belgium
hcfmusp.citation.scopus20
hcfmusp.contributor.author-fmusphcTHIAGO FREIRE PINTO BEZERRA
hcfmusp.contributor.author-fmusphcRICHARD LOUIS VOEGELS
hcfmusp.description.articlenumber27
hcfmusp.description.volume42
hcfmusp.origemWOS
hcfmusp.origem.pubmed23663431
hcfmusp.origem.scopus2-s2.0-84896913550
hcfmusp.origem.wosWOS:000318410000002
hcfmusp.publisher.cityLONDON
hcfmusp.publisher.countryENGLAND
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