Transcranial direct current stimulation is safe and effective in autoimmune myopathies: a randomised, double-blind, sham-controlled trial

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSOUSA, L. F. A. de
dc.contributor.authorMISSE, R. G.
dc.contributor.authorSANTOS, L. M. dos
dc.contributor.authorTANAKA, C.
dc.contributor.authorGREVE, J. M. A.
dc.contributor.authorBAPTISTA, A. F.
dc.contributor.authorSHINJO, S. K.
dc.date.accessioned2023-06-21T14:08:01Z
dc.date.available2023-06-21T14:08:01Z
dc.date.issued2023
dc.description.abstractObjective We aimed to assess the safety and efficacy of transcranial direct current stimulation (tDCS) in patients with systemic autoimmune myopathies (SAMs).Methods This prospective, randomised, sham-controlled, double-blind, study included 20 patients with SAMs allocated to receive sham or active tDCS (2mA, 20 minutes, 3 days). Electrodes were positioned with the anode over the C1 or C2, whereas the cathode was placed over the Fp2 or Fp1, respectively. The groups were evaluated in four periods with specific questionnaires and functional tests: pre-stimulation and after 30 minutes, three weeks, and eight weeks post-tDCS.Results Two patients from the sham group withdrew after the three sessions. The demographic data, type of myositis, disease duration, and disease status were comparable between the active and sham tDCS groups. After interventions, in the active tDCS group, the physical aspects of SF-36 in week eight, mean and better timed up-and-go test at each evaluation, peak torque of stimulated inferior limb extension improved significantly (p<0.05). The emotional aspect of SF-36 decreased only in the active tDCS group (p<0.001). The patients' adherence to the protocol was 100% and no serious adverse event was reported, including disease relapses.Conclusion This study evidences the safety of tDCS, as well as its potential efficacy in improving muscle strength and function in SAMs patients. More studies with a larger sample and longer tDCS sessions are necessary to corroborate the results of the present study.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2019/12155-5, 2019/11776-6]
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [303379/2018-9]
dc.description.sponsorshipFaculdade de Medicina da USP
dc.identifier.citationCLINICAL AND EXPERIMENTAL RHEUMATOLOGY, v.41, n.2, p.221-229, 2023
dc.identifier.eissn1593-098X
dc.identifier.issn0392-856X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/53894
dc.language.isoeng
dc.publisherCLINICAL & EXPER RHEUMATOLOGYeng
dc.relation.ispartofClinical and Experimental Rheumatology
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright CLINICAL & EXPER RHEUMATOLOGYeng
dc.subjectinflammatory myopathieseng
dc.subjectmyositiseng
dc.subjectneuromodulationeng
dc.subjectsafetyeng
dc.subjectquality of lifeeng
dc.subject.otheridiopathic inflammatory myopathieseng
dc.subject.otheroutcome assessmenteng
dc.subject.otheranodal-tdcseng
dc.subject.otheradulteng
dc.subject.otherclassificationeng
dc.subject.otherguidelineseng
dc.subject.otherfatigueeng
dc.subject.otherupdateeng
dc.subject.wosRheumatologyeng
dc.titleTranscranial direct current stimulation is safe and effective in autoimmune myopathies: a randomised, double-blind, sham-controlled trialeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.contributor.author-fmusphcLUIZ FELIPE ADSUARA DE SOUSA
hcfmusp.contributor.author-fmusphcRAFAEL GIOVANE MISSE
hcfmusp.contributor.author-fmusphcLUCAS DE MACEDO DOS SANTOS
hcfmusp.contributor.author-fmusphcCLARICE TANAKA
hcfmusp.contributor.author-fmusphcJULIA MARIA D ANDREA GREVE
hcfmusp.contributor.author-fmusphcABRAHAO FONTES BAPTISTA
hcfmusp.contributor.author-fmusphcSAMUEL KATSUYUKI SHINJO
hcfmusp.description.beginpage221
hcfmusp.description.endpage229
hcfmusp.description.issue2
hcfmusp.description.volume41
hcfmusp.origemWOS
hcfmusp.origem.pubmed35383556
hcfmusp.origem.wosWOS:000952863200006
hcfmusp.publisher.cityPISAeng
hcfmusp.publisher.countryITALYeng
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