Olfaction in nasal polyp patients after Reboot surgery: an endotype-based prospective study
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Citações na Scopus
5
Tipo de produção
article
Data de publicação
2023
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER
Autores
DELEMARRE, Tim
HOLTAPPELS, Gabriele
ZELE, Thibaut Van
DERYCKE, Lara
BONNE, Ellen
EECKELS, Anne-Sophie
ZHANG, Nan
BACHERT, Claus
Citação
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, v.280, n.6, p.2821-2830, 2023
Resumo
Purpose To report biomarkers present in the olfactory mucosa in chronic rhinosinusitis with nasal polyps (CRSwNP) in comparison with nasal polyps and to nasal mucosal tissues from control patients. To evaluate the kinetics of smell over 6 months in patients who underwent Reboot surgery. Methods Cohort study from May 2021 to May 2022. We collected samples of olfactory mucosa and nasal polyps from 16 CRSwNP patients and inferior turbinate samples from 20 control subjects. The study was not randomized for surgical and/or medical treatment. Samples were analyzed by Luminex and Unicap 100 to measure biomarkers of inflammation (IL1-beta, IL4, IL5, IL6, IL17, CCL3, CCL4, G-CSF, SE-IgE, total IgE and ECP). 12 of the CRSwNP patients underwent Extended Sniffin'tests at timepoints 1-4 days pre-surgery, and 1, 3 and 6 months after Reboot surgery. Results Type-2 markers were significantly elevated in OM and polyp tissue in CRSwNP (n = 16) vs. controls (n = 20), P < 0.05. TDI scores improved already 1 month (P < 0.05) after surgery and remained stable for 6 months. Type-2 inflammation in nasal polyps was associated with decreased sense of smell and taste before surgery, but improved after surgery (P = 0.048). Type-3 inflammation was present in the olfactory mucosa and was associated with a better sense of smell before surgery, but a smaller improvement of smell afterward. Conclusions Type-2 inflammation is present in the olfactory mucosa in CRSwNP patients and is associated with smell loss. Reboot surgery, aiming to completely remove inflamed sinus mucosa, significantly improves the smell in this group of patients.
Palavras-chave
Anosmia, Nasal polyps, Nasal surgical procedures, Olfaction disorders, Sinusitis, Smell
Referências
- AlBader A, 2017, LARYNGOSCOPE, V127, P2203, DOI 10.1002/lary.26689
- Alsharif S, 2019, LARYNGOSCOPE, V129, P1286, DOI 10.1002/lary.27815
- Bachert C, 2022, INT FORUM ALLERGY RH, V12, P1191, DOI 10.1002/alr.22964
- Bachert C, 2021, J ALLERGY CLIN IMMUN, V147, P29, DOI 10.1016/j.jaci.2020.11.013
- Bachert C, 2020, NAT REV DIS PRIMERS, V6, DOI 10.1038/s41572-020-00218-1
- Bachert C, 2020, J ALLER CL IMM-PRACT, V8, P1514, DOI 10.1016/j.jaip.2020.03.007
- Bachert C, 2020, RHINOLOGY, V58, P10, DOI 10.4193/Rhin18.282
- Bachert C, 2019, LANCET, V394, P1638, DOI 10.1016/S0140-6736(19)31881-1
- Bachert C, 2019, J ALLER CL IMM-PRACT, V7, P2447, DOI 10.1016/j.jaip.2019.03.023
- Bachert C, 2018, J ALLERGY CLIN IMMUN, V141, P1543, DOI 10.1016/j.jaci.2018.03.004
- Bachert C, 2016, J ALLER CL IMM-PRACT, V4, P621, DOI 10.1016/j.jaip.2016.05.004
- Canonica GW, 2011, J ALLERGY CLIN IMMUN, V127, P44, DOI 10.1016/j.jaci.2010.09.037
- De Regloix S, 2013, Rev Laryngol Otol Rhinol (Bord), V134, P145
- Delank K.-W., 1998, Rhinology (Utrecht), V36, P15
- Delemarre T, 2020, J ALLERGY CLIN IMMUN, V146, P337, DOI 10.1016/j.jaci.2020.04.040
- Federspil PA, 2008, RHINOLOGY, V46, P184
- Gevaert P, 2020, J ALLERGY CLIN IMMUN, V146, P595, DOI 10.1016/j.jaci.2020.05.032
- Gomes SC, 2022, EUR ARCH OTO-RHINO-L, V279, P5691, DOI 10.1007/s00405-022-07470-z
- Hadley K, 2004, OTOLARYNG CLIN N AM, V37, P1115, DOI 10.1016/j.otc.2004.06.009
- Hamilton JD, 2021, CLIN EXP ALLERGY, V51, P915, DOI 10.1111/cea.13954
- HOSEMANN W, 1991, EUR ARCH OTO-RHINO-L, V248, P390, DOI 10.1007/BF01463560
- Hummel T, 2007, EUR ARCH OTO-RHINO-L, V264, P237, DOI 10.1007/s00405-006-0173-0
- Hummel T, 1997, CHEM SENSES, V22, P39, DOI 10.1093/chemse/22.1.39
- JAFEK BW, 1983, LARYNGOSCOPE, V93, P1576, DOI 10.1288/00005537-198312000-00011
- Jankowski R, 2006, Rev Laryngol Otol Rhinol (Bord), V127, P131
- Jankowski R, 2018, EUR ANN OTORHINOLARY, V135, P327, DOI 10.1016/j.anorl.2018.05.006
- Jankowski R, 2018, EUR ANN OTORHINOLARY, V135, P191, DOI 10.1016/j.anorl.2018.03.004
- Jankowski R, 2003, RHINOLOGY, V41, P211
- Jankowski R, 2003, RHINOLOGY, V41, P220
- Kato A, 2022, ALLERGY, V77, P812, DOI 10.1111/all.15074
- Khan A, 2019, RHINOLOGY, V57, P32, DOI 10.4193/Rhin17.255
- Kobal G., 1996, Rhinology (Utrecht), V34, P222
- Lane AP, 2002, LARYNGOSCOPE, V112, P1183, DOI 10.1097/00005537-200207000-00007
- Lipworth BJ, 2021, J ALLER CL IMM-PRACT, V9, P4235, DOI 10.1016/j.jaip.2021.07.023
- LOVELL MA, 1982, ARCH OTOLARYNGOL, V108, P247
- Malvezzi L, 2020, BMJ CASE REP, V13, DOI 10.1136/bcr-2019-233726
- Morse JC, 2021, J ASTHMA ALLERGY, V14, P873, DOI 10.2147/JAA.S258438
- Mullol J, 2022, J ALLER CL IMM-PRACT, V10, P1086, DOI 10.1016/j.jaip.2021.09.037
- NAKASHIMA T, 1984, ARCH OTOLARYNGOL, V110, P641
- Olsson P, 2010, RHINOLOGY, V48, P150, DOI 10.4193/Rhin09.097
- Pinna FD, 2013, INT ARCH OTORHINOLAR, V17, P131, DOI 10.7162/S1809-97772013000200004
- Soler ZM, 2021, J ALLERGY CLIN IMMUN, V147, P1732, DOI 10.1016/j.jaci.2021.01.021
- Spergel AKR, 2018, CURR ALLERGY ASTHM R, V18, DOI 10.1007/s11882-018-0801-y
- Tomassen P, 2016, J ALLERGY CLIN IMMUN, V137, P1449, DOI 10.1016/j.jaci.2015.12.1324
- Yonekura S, 2021, J ALLER CL IMM-PRACT, V9, P4103, DOI 10.1016/j.jaip.2021.06.060