Temporal Evaluation of Craniofacial Relationships in Apert Syndrome

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLU, Xiaona
dc.contributor.authorFORTE, Antonio Jorge
dc.contributor.authorSAWH-MARTINEZ, Rajendra
dc.contributor.authorWU, Robin
dc.contributor.authorCABREJO, Raysa
dc.contributor.authorGABRICK, Kyle
dc.contributor.authorSTEINBACHER, Derek M.
dc.contributor.authorALPEROVICH, Michael
dc.contributor.authorALONSO, Nivaldo
dc.contributor.authorPERSING, John A.
dc.date.accessioned2019-06-26T17:26:26Z
dc.date.available2019-06-26T17:26:26Z
dc.date.issued2019
dc.description.abstractComplicated craniofacial malformations interfacing with multiple intracellular regulatory mechanisms, lead to ambiguous growth patterns in Apert syndrome. This study aims to explore the chronology and pathogenesis of the development of craniofacial anatomic relationships and to verify the positional correlates between skull and facial structures in Apert syndrome. Fifty-four computed tomography scans (Apert, n = 18; control, n = 36) were included and divided into 3 age subgroups. Craniofacial 3-dimensional cephalometries were analyzed by Materialize software. The angle between sella-nasion plane and maxillary plane widens 7.748 (P = 0.003) prior to 6 months of age; thereafter, this widening increases by 10.368 (P< 0.001) in 6 months to 2 years of age, and remains increased by 8.98 (P = 0.046) throughout childhood. The angle between Frankfort horizontal plane and maxillary plane widens 5.178 (P = 0.022) before 6 months. Angles SNA, SNB, and ANB showed decreases, averaging 12.238 (P< 0.001), 5.198 (P = 0.004), and 6.728 (P = 0.001), respectively. The linear measurements showed synchronicity and continuing deformity into adulthood. Between 6 months to 2 years of age, the distance from sella to nasion (S-N), anterior nasal spine (S-ANS), and posterior nasal spine (S-PNS) decreased 8% (P = 0.006), 16% (P< 0.001), and 19% (P = 0.002), respectively, and remained shortened into adulthood. The angulation changes occur earlier in development than linear distance reduction in Apert syndrome patients compared with controls. Angular adjustments were not sufficient to maintain normal cranial base length. Facial deformity of Apert syndrome temporally begins with the midface, and affects orbit and mandible later in life.eng
dc.description.indexMEDLINEeng
dc.identifier.citationJOURNAL OF CRANIOFACIAL SURGERY, v.30, n.2, p.317-325, 2019
dc.identifier.doi10.1097/SCS.0000000000004836
dc.identifier.eissn1536-3732
dc.identifier.issn1049-2275
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/32393
dc.language.isoeng
dc.publisherLIPPINCOTT WILLIAMS & WILKINSeng
dc.relation.ispartofJournal of Craniofacial Surgery
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright LIPPINCOTT WILLIAMS & WILKINSeng
dc.subject3-D cephalometrieseng
dc.subjectApert syndromeeng
dc.subjectcraniofacial relationshipeng
dc.subjectdevelopmenteng
dc.subject.othergrowth-factor receptor-3eng
dc.subject.othercranial baseeng
dc.subject.otherprenatal-diagnosiseng
dc.subject.othercrouzon-syndromeseng
dc.subject.otherfacial growtheng
dc.subject.othermutationseng
dc.subject.otherultrasoundeng
dc.subject.wosSurgeryeng
dc.titleTemporal Evaluation of Craniofacial Relationships in Apert Syndromeeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryChina
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisocn
hcfmusp.affiliation.countryisous
hcfmusp.author.externalLU, Xiaona:Chinese Acad Med Sci, Peking Union Med Coll, Plast Surg Hosp, Beijing, Peoples R China
hcfmusp.author.externalFORTE, Antonio Jorge:Mayo Clin Florida, Div Plast & Reconstruct Surg, Jacksonville, FL USA
hcfmusp.author.externalSAWH-MARTINEZ, Rajendra:Yale Sch Med, Sect Plast & Reconstruct Surg, 330 Cedar St,3rd Floor,Boardman Bldg, New Haven, CT 06520 USA
hcfmusp.author.externalWU, Robin:Yale Sch Med, Sect Plast & Reconstruct Surg, 330 Cedar St,3rd Floor,Boardman Bldg, New Haven, CT 06520 USA
hcfmusp.author.externalCABREJO, Raysa:Yale Sch Med, Sect Plast & Reconstruct Surg, 330 Cedar St,3rd Floor,Boardman Bldg, New Haven, CT 06520 USA
hcfmusp.author.externalGABRICK, Kyle:Yale Sch Med, Sect Plast & Reconstruct Surg, 330 Cedar St,3rd Floor,Boardman Bldg, New Haven, CT 06520 USA
hcfmusp.author.externalSTEINBACHER, Derek M.:Yale Sch Med, Sect Plast & Reconstruct Surg, 330 Cedar St,3rd Floor,Boardman Bldg, New Haven, CT 06520 USA
hcfmusp.author.externalALPEROVICH, Michael:Yale Sch Med, Sect Plast & Reconstruct Surg, 330 Cedar St,3rd Floor,Boardman Bldg, New Haven, CT 06520 USA
hcfmusp.author.externalPERSING, John A.:Yale Sch Med, Sect Plast & Reconstruct Surg, 330 Cedar St,3rd Floor,Boardman Bldg, New Haven, CT 06520 USA
hcfmusp.citation.scopus8
hcfmusp.contributor.author-fmusphcNIVALDO ALONSO
hcfmusp.description.beginpage317
hcfmusp.description.endpage325
hcfmusp.description.issue2
hcfmusp.description.volume30
hcfmusp.origemWOS
hcfmusp.origem.pubmed30358751
hcfmusp.origem.scopus2-s2.0-85067301391
hcfmusp.origem.wosWOS:000467717400044
hcfmusp.publisher.cityPHILADELPHIAeng
hcfmusp.publisher.countryUSAeng
hcfmusp.relation.referenceAlbuquerque Marco Antônio Portela, 2004, Braz. oral res., V18, P35, DOI 10.1590/S1806-83242004000100007eng
hcfmusp.relation.referenceAlmeida MR, 2009, CLIN GENET, V75, P150, DOI 10.1111/j.1399-0004.2008.01123.xeng
hcfmusp.relation.referenceBACHMAYER DI, 1986, AM J ORTHOD DENTOFAC, V90, P420, DOI 10.1016/0889-5406(86)90007-7eng
hcfmusp.relation.referenceBHAT M, 1985, ANGLE ORTHOD, V55, P269eng
hcfmusp.relation.referenceBonaventure J, 1996, ACTA PAEDIATR, V85, P33, DOI 10.1111/j.1651-2227.1996.tb14291.xeng
hcfmusp.relation.referenceCarinci F, 2005, J CRANIOFAC SURG, V16, P361, DOI 10.1097/01.SCS.0000157078.53871.11eng
hcfmusp.relation.referenceCOSTARASVOLARICH M, 1984, AM J ORTHOD DENTOFAC, V85, P475, DOI 10.1016/0002-9416(84)90087-3eng
hcfmusp.relation.referenceENLOW DH, 1971, ANGLE ORTHOD, V41, P161eng
hcfmusp.relation.referenceENLOW DH, 1966, AMER J ORTHODONTICS, V52, P283, DOI 10.1016/0002-9416(66)90169-2eng
hcfmusp.relation.referenceFadda M, 2015, ANN STOMATOL, V6, P58, DOI 10.11138/ads/2015.6.2.058eng
hcfmusp.relation.referenceFerros I, 2015, EUR J ORTHODONT, V37, P403, DOI 10.1093/ejo/cju066eng
hcfmusp.relation.referenceForrest CR, 2013, PLAST RECONSTR SURG, V131, p86E, DOI 10.1097/PRS.0b013e318272c12beng
hcfmusp.relation.referenceForte AJ, 2014, PLAST RECONSTR SURG, V134, P285, DOI 10.1097/PRS.0000000000000360eng
hcfmusp.relation.referenceGOLDBERG JS, 1981, J ORAL SURG, V39, P489eng
hcfmusp.relation.referenceHallgrimsson B, 2015, CURR TOP DEV BIOL, V115, P561, DOI 10.1016/bs.ctdb.2015.09.003eng
hcfmusp.relation.referenceHoyte D A, 1991, Neurosurg Clin N Am, V2, P515eng
hcfmusp.relation.referenceKIM H, 1986, HUM GENET, V73, P93, DOI 10.1007/BF00292674eng
hcfmusp.relation.referenceKim SJ, 2013, AM J ORTHOD DENTOFAC, V144, P330, DOI 10.1016/j.ajodo.2013.03.024eng
hcfmusp.relation.referenceKrarup S, 2005, J ANAT, V207, P669, DOI 10.1111/j.1469-7580.2005.00479.xeng
hcfmusp.relation.referenceKREIBORG S, 1976, CLEFT PALATE J, V13, P296eng
hcfmusp.relation.referenceKreiborg S, 1999, J CRAN GENET DEV BIO, V19, P1eng
hcfmusp.relation.referenceKreiborg S, 2010, J CRANIOFAC SURG, V21, P1354, DOI 10.1097/SCS.0b013e3181ef2b53eng
hcfmusp.relation.referenceNie XG, 2005, ACTA ODONTOL SCAND, V63, P127, DOI 10.1080/00016350510019847eng
hcfmusp.relation.referencePETERSONFALZONE SJ, 1981, CLEFT PALATE J, V18, P237eng
hcfmusp.relation.referencePOSNICK JC, 1994, PLAST RECONSTR SURG, V93, P489, DOI 10.1097/00006534-199493030-00007eng
hcfmusp.relation.referenceRosenberg P, 1997, PLAST RECONSTR SURG, V99, P1396, DOI 10.1097/00006534-199704001-00030eng
hcfmusp.relation.referenceROUSSEAU F, 1994, NATURE, V371, P252, DOI 10.1038/371252a0eng
hcfmusp.relation.referenceRubio EI, 2016, PEDIATR RADIOL, V46, P709, DOI 10.1007/s00247-016-3550-xeng
hcfmusp.relation.referenceTahiri Y, 2014, J ORAL MAXIL SURG, V72, P1173, DOI 10.1016/j.joms.2013.11.015eng
hcfmusp.relation.referenceTaylor JA, 2017, PLAST RECONSTR SURG, V140, p82E, DOI 10.1097/PRS.0000000000003524eng
hcfmusp.relation.referenceWerner H, 2018, CHILD NERV SYST, V34, P1563, DOI 10.1007/s00381-018-3740-yeng
hcfmusp.relation.reference1999, BONE, V24, P337eng
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