Effect of age at disease onset in the clinical profile of spondyloarthritis: a study of 1424 Brazilian patients

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art_GONCALVES_Effect_of_age_at_disease_onset_in_the_2012.PDF (378.23 KB)
Citações na Scopus
33
Tipo de produção
article
Data de publicação
2012
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
CLINICAL & EXPER RHEUMATOLOGY
Autores
SKARE, T. L.
LEITE, N.
BORTOLUZZO, A. B.
SILVA, J. A. B. da
XIMENES, A. C.
BERTOLO, M. B.
RIBEIRO, S. L. E.
KEISERMAN, M.
MENIN, R.
Citação
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, v.30, n.3, p.351-357, 2012
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objectives To analyse demographic and clinical variables in patients with disease onset before and after 40, 45 and 50 years in a large series of Brazilian SpA patients. Methods A common protocol of investigation was prospectively applied to 1424 SpA patients in 29 centres distributed through the main geographical regions in Brazil. The mean age at disease onset was 28.56 +/- 12.34 years, with 259 patients (18.2%) referring disease onset after 40 years, 15.1 (10.6%) after 45 years and 81 (5.8%) after 50 years. Clinical and demographic variables and disease indices (BASDAI, BASFI, BASRI, MASES, ASQoL) were investigated. Ankylosing spondylitis was the most frequent disease (66.3%), followed by psoriatic arthritis (18%), undifferentiated SpA (6.7%), reactive arthritis (5.5%), and enteropathic arthritis (3.5%). Results Comparing the groups according to age of disease onset, those patients with later onset presented statistical association with female gender, peripheral arthritis, dactylitis, nail involvement and psoriasis, as well as negative statistical association with inflammatory low hack pain, alternating buttock pain, radiographic sacroiliitis, hip involvement, positive familial history, HLA-B27 and uveitis. BASDAI, BASFI and quality of life, as well as physicians and patient's global assessment, were similar in all the groups. Radiographic indices showed worse results in the younger age groups. Conclusion There are two different clinical patterns in SpA defined by age at disease onset: one with predominance of axial symptoms in the group with disease onset <= 40 years and another favouring the peripheral manifestations in those with later disease onset.
Palavras-chave
spondyloarthritis, age at onset, outcome
URI
https://observatorio.fm.usp.br/handle/OPI/1317
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Coleções
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/17