Metabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLEANCA, Camila C.
dc.contributor.authorNUNES, Valeria S.
dc.contributor.authorPANZOLDO, Natalia B.
dc.contributor.authorZAGO, Vanessa S.
dc.contributor.authorPARRA, Eliane S.
dc.contributor.authorCAZITA, Patricia M.
dc.contributor.authorJAUHIAINEN, Matti
dc.contributor.authorPASSARELLI, Marisa
dc.contributor.authorNAKANDAKARE, Edna R.
dc.contributor.authorFARIA, Eliana C. de
dc.contributor.authorQUINTAO, Eder C. R.
dc.date.accessioned2014-04-25T21:50:18Z
dc.date.available2014-04-25T21:50:18Z
dc.date.issued2013
dc.description.abstractBackground: We have searched if plasma high density lipoprotein-cholesterol (HDL-C) concentration interferes simultaneously with whole-body cholesterol metabolism and insulin sensitivity in normal weight healthy adult subjects. Methods: We have measured the activities of several plasma components that are critically influenced by insulin and that control lipoprotein metabolism in subjects with low and high HDL-C concentrations. These parameters included cholesteryl ester transfer protein (CETP), phospholipid transfer protein (PLTP), lecithin cholesterol acyl transferase (LCAT), post-heparin lipoprotein lipase (LPL), hepatic lipase (HL), pre-beta-1HDL, and plasma sterol markers of cholesterol synthesis and intestinal absorption. Results: In the high-HDL-C group, we found lower plasma concentrations of triglycerides, alanine aminotransferase, insulin, HOMA-IR index, activities of LCAT and HL compared with the low HDL-C group; additionally, we found higher activity of LPL and pre-beta-1HDL concentration in the high-HDL-C group. There were no differences in the plasma CETP and PLTP activities. Conclusions: These findings indicate that in healthy hyperalphalipoproteinemia subjects, several parameters that control the metabolism of plasma cholesterol and lipoproteins are related to a higher degree of insulin sensitivity.
dc.description.indexMEDLINE
dc.description.sponsorshipFAPESP (Sao Paulo Research Foundation) [06/60585-9, 08/50185-9]
dc.identifier.citationCARDIOVASCULAR DIABETOLOGY, v.12, article ID 173, 7p, 2013
dc.identifier.doi10.1186/1475-2840-12-173
dc.identifier.issn1475-2840
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/5074
dc.language.isoeng
dc.publisherBIOMED CENTRAL LTD
dc.relation.ispartofCardiovascular Diabetology
dc.rightsopenAccess
dc.rights.holderCopyright BIOMED CENTRAL LTD
dc.subjectInsulin resistance
dc.subjectHDL-C concentration
dc.subjectLipoprotein lipases
dc.subjectLecithin cholesterol acyl transferase
dc.subjectPre-beta1 HDL
dc.subjectPlasma cholesterol metabolism markers
dc.subjectCholesteryl ester transfer protein
dc.subjectPhospholipid transfer protein
dc.subject.otherhigh-density-lipoprotein
dc.subject.othertransfer protein-activity
dc.subject.othertype-2 diabetes-mellitus
dc.subject.otherhepatic lipase activity
dc.subject.otherintima-media thickness
dc.subject.othernondiabetic subjects
dc.subject.otherester transfer
dc.subject.otherresistance
dc.subject.otherobesity
dc.subject.otheracyltransferase
dc.subject.wosCardiac & Cardiovascular Systems
dc.subject.wosEndocrinology & Metabolism
dc.titleMetabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryFinlândia
hcfmusp.affiliation.countryisofi
hcfmusp.author.externalPANZOLDO, Natalia B.:Univ Estadual Campinas, UNICAMP, Sch Med Sci, Dept Clin Pathol, BR-13083970 Campinas, SP, Brazil
hcfmusp.author.externalZAGO, Vanessa S.:Univ Estadual Campinas, UNICAMP, Sch Med Sci, Dept Clin Pathol, BR-13083970 Campinas, SP, Brazil
hcfmusp.author.externalPARRA, Eliane S.:Univ Estadual Campinas, UNICAMP, Sch Med Sci, Dept Clin Pathol, BR-13083970 Campinas, SP, Brazil
hcfmusp.author.externalJAUHIAINEN, Matti:Natl Inst Hlth & Welf, Publ Hlth Genom Res Unit, Helsinki, Finland
hcfmusp.author.externalFARIA, Eliana C. de:Univ Estadual Campinas, UNICAMP, Sch Med Sci, Dept Clin Pathol, BR-13083970 Campinas, SP, Brazil
hcfmusp.citation.scopus15
hcfmusp.contributor.author-fmusphcCAMILA CANTEIRO LEANCA
hcfmusp.contributor.author-fmusphcVALERIA SUTTI NUNES
hcfmusp.contributor.author-fmusphcPATRICIA MIRALDA CAZITA
hcfmusp.contributor.author-fmusphcMARISA PASSARELLI
hcfmusp.contributor.author-fmusphcEDNA REGINA NAKANDAKARE
hcfmusp.contributor.author-fmusphcEDER CARLOS ROCHA QUINTAO
hcfmusp.description.articlenumber173
hcfmusp.description.volume12
hcfmusp.origemWOS
hcfmusp.origem.pubmed24267726
hcfmusp.origem.scopus2-s2.0-84887978325
hcfmusp.origem.wosWOS:000329804400001
hcfmusp.publisher.cityLONDON
hcfmusp.publisher.countryENGLAND
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