Biochemical recurrence rates are similar for pT2-positive surgical margins and pT3a

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLEITE, Katia R. M.
dc.contributor.authorHARTMANN, Carolina
dc.contributor.authorREIS, Sabrina T.
dc.contributor.authorVIANA, Nayara
dc.contributor.authorDALL'OGLIO, Marcos F.
dc.contributor.authorST'ANNA, Alexandre C.
dc.contributor.authorNESRALLAH, Adriano
dc.contributor.authorNESRALLAH, Luciano
dc.contributor.authorANTUNES, Alberto A.
dc.contributor.authorCAMARA-LOPES, Luiz H.
dc.contributor.authorSROUGI, Miguel
dc.date.accessioned2014-09-30T14:36:53Z
dc.date.available2014-09-30T14:36:53Z
dc.date.issued2014
dc.description.abstractObjective: Histological details of positive surgical margins in radical prostatectomy specimens have been related to outcome after surgery in rare studies recently published. Our objective is to assess whether the status of surgical margins, the extent and the Gleason score of positive margins, and the extent of the extraprostatic extension are predictive of biochemical recurrence post-radical prostatectomy. Materials and Methods: Three hundred sixty-five radical prostatectomy specimens were analyzed. The length of the positive surgical margin and extraprostatic extension and the Gleason score of the margin were recorded. Statistical analyses examined the predictive value of these variables for biochemical recurrence. Results: 236 patients were stage pT2R0, 58 pT2R1, 25 pT3R0 and 46 pT3R1. Biochemical recurrence occurred in 11%, 31%, 20% and 45.7% of pT2R0, pT2R1, pT3R0 and pT3R1, respectively. The extent of the positive surgical margins and the Gleason score of the positive surgical margins were not associated with biochemical recurrence in univariate analysis in a mean follow up period of 35.9 months. In multivariate analyses, only the status of the surgical margins and the global Gleason score were associated with biochemical recurrence, with a risk of recurrence of 3.1 for positive surgical margins and of 3.8 for a Gleason score > 7. Conclusion: Positive surgical margin and the global Gleason score are significant risk factors for biochemical recurrence post-radical prostatectomy, regardless of the extent of the surgical margin, the extent of the extraprostatic extension, or the local Gleason score of the positive surgical margin or extraprostatic tissue. pT2R1 disease behaves as pT3R0 and should be treated similarly.
dc.description.indexMEDLINE
dc.identifier.citationINTERNATIONAL BRAZ J UROL, v.40, n.2, p.146-153, 2014
dc.identifier.doi10.1590/S1677-5538.IBJU.2014.02.03
dc.identifier.eissn1677-6119
dc.identifier.issn1677-5538
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/7313
dc.language.isoeng
dc.publisherBRAZILIAN SOC UROL
dc.relation.ispartofInternational Braz J Urol
dc.rightsopenAccess
dc.rights.holderCopyright BRAZILIAN SOC UROL
dc.subjectProstatic Neoplasms
dc.subjectNeoplasm Grading
dc.subjectPrognosis
dc.subjectProstatectomy
dc.subject.otherprostate-specific antigen
dc.subject.otherradical prostatectomy
dc.subject.otheradjuvant radiotherapy
dc.subject.othercancer recurrence
dc.subject.otherpositive margins
dc.subject.othergleason grade
dc.subject.otherimpact
dc.subject.otherspecimens
dc.subject.otherextent
dc.subject.otherprogression
dc.subject.wosUrology & Nephrology
dc.titleBiochemical recurrence rates are similar for pT2-positive surgical margins and pT3a
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalHARTMANN, Carolina:Genoa Biotechnol, Sao Paulo, Brazil
hcfmusp.author.externalST'ANNA, Alexandre C.:Univ Sao Paulo, Sch Med, Lab Med, Urol LIM 55, Sao Paulo, Brazil
hcfmusp.author.externalNESRALLAH, Luciano:Genoa Biotechnol, Sao Paulo, Brazil
hcfmusp.author.externalCAMARA-LOPES, Luiz H.:Genoa Biotechnol, Sao Paulo, Brazil
hcfmusp.citation.scopus6
hcfmusp.contributor.author-fmusphcKATIA RAMOS MOREIRA LEITE
hcfmusp.contributor.author-fmusphcSABRINA THALITA DOS REIS FARIA
hcfmusp.contributor.author-fmusphcNAYARA IZABEL VIANA MOURA
hcfmusp.contributor.author-fmusphcMARCOS FRANCISCO DALL'OGLIO
hcfmusp.contributor.author-fmusphcADRIANO JOAO NESRALLAH
hcfmusp.contributor.author-fmusphcALBERTO AZOUBEL ANTUNES
hcfmusp.contributor.author-fmusphcMIGUEL SROUGI
hcfmusp.description.beginpage146
hcfmusp.description.endpage153
hcfmusp.description.issue2
hcfmusp.description.volume40
hcfmusp.origemWOS
hcfmusp.origem.pubmed24856481
hcfmusp.origem.scieloSCIELO:S1677-55382014000200146
hcfmusp.origem.scopus2-s2.0-84902674410
hcfmusp.origem.wosWOS:000337913500003
hcfmusp.publisher.cityRIO DE JANEIRO
hcfmusp.publisher.countryBRAZIL
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