Use of dexmedetomidine for sedation in mechanically ventilated adult ICU patients: a rapid practice guideline

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art_MOLLER_Use_of_dexmedetomidine_for_sedation_in_mechanically_ventilated_2022.PDF (1.37 MB)
Citações na Scopus
20
Tipo de produção
article
Data de publicação
2022
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER
Autores
MOLLER, Morten H.
ALHAZZANI, Waleed
LEWIS, Kimberley
BELLEY-COTE, Emilie
GRANHOLM, Anders
CENTOFANTI, John
MCINTYRE, William B.
SPENCE, Jessica
DUHAILIB, Zainab Al
NEEDHAM, Dale M.
Citação
INTENSIVE CARE MEDICINE, v.48, n.7, p.801-810, 2022
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Purpose The aim of this Intensive Care Medicine Rapid Practice Guideline (ICM-RPG) was to formulate evidence-based guidance for the use of dexmedetomidine for sedation in invasively mechanically ventilated adults in the intensive care unit (ICU). Methods We adhered to the methodology for trustworthy clinical practice guidelines, including use of the Grading of Recommendations Assessment, Development, and Evaluation approach to assess the certainty of evidence, and the Evidence-to-Decision framework to generate recommendations. The guideline panel comprised 28 international panelists, including content experts, ICU clinicians, methodologists, and patient representatives. Through teleconferences and web-based discussions, the panel provided input on the balance and magnitude of the desirable and undesirable effects, the certainty of evidence, patients' values and preferences, costs and resources, feasibility, acceptability, and research priorities. Results The ICM-RPG panel issued one weak recommendation (suggestion) based on overall moderate certainty of evidence: ""In invasively mechanically ventilated adult ICU patients, we suggest using dexmedetomidine over other sedative agents, if the desirable effects including a reduction in delirium are valued over the undesirable effects including an increase in hypotension and bradycardia"". Conclusion This ICM-RPG provides updated evidence-based guidance on the use of dexmedetomidine for sedation in mechanically ventilated adults, and outlines uncertainties and research priorities.
Palavras-chave
ICM-RPG, Clinical practice guideline, Dexmedetomidine, Sedation
URI
https://observatorio.fm.usp.br/handle/OPI/48605
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Coleções
Artigos e Materiais de Revistas Científicas - FM/Outros
Artigos e Materiais de Revistas Científicas - LIM/09