Are antimicrobial stewardship programs effective strategies for preventing antibiotic resistance? A systematic review

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorBERTOLLO, Leandro G.
dc.contributor.authorLUTKEMEYER, Diego S.
dc.contributor.authorLEVIN, Anna S.
dc.date.accessioned2018-09-13T15:23:58Z
dc.date.available2018-09-13T15:23:58Z
dc.date.issued2018
dc.description.abstractBackground: Antimicrobial stewardship programs (ASPs) have been proposed as a solution for the global burden of antibiotic resistance, despite the lack of evidence on the subject. Objective: To analyze the role of ASPs in reducing bacterial resistance to antibiotics in hospital settings. Data sources: A review in PubMed, Scopus, LILACS, and SciELO databases was performed. The period analyzed was January 1, 2012-January 4, 2017. Eligibility criteria: Studies that related ASPs to bacterial resistance. Data extraction: All studies that did not focus on ASPs were removed. Antifungal and antiviral programs were excluded. Results: Only 8 studies had quasi-experimental designs, and none were controlled trials. ASP strategies and microorganism-antibiotic pairs evaluated varied widely. Seven studies were classified as presenting clearly positive results, 3 had limited positive results, 7 had doubtful results, 4 had negative results, and 5 had noninterpretable results. The implementation of new infection control practices occurred in 7 studies. Limitations: There are yet few studies on this matter, and most of them have inadequate study designs. Great heterogeneity between study features was detrimental to drawing evidence-based conclusions. Conclusions: There is no solid evidence that ASPs are effective in reducing antibiotic resistance in hospital settings. We uphold the need for more studies with appropriate study designs, standardized ASP interventions targeting common microorganism-antibiotic pairs, and avoiding simultaneous implementation of infection control practices.
dc.description.indexMEDLINE
dc.identifier.citationAMERICAN JOURNAL OF INFECTION CONTROL, v.46, n.7, p.824-836, 2018
dc.identifier.doi10.1016/j.ajic.2018.01.002
dc.identifier.eissn1527-3296
dc.identifier.issn0196-6553
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/28132
dc.language.isoeng
dc.publisherMOSBY-ELSEVIER
dc.relation.ispartofAmerican Journal of Infection Control
dc.rightsrestrictedAccess
dc.rights.holderCopyright MOSBY-ELSEVIER
dc.subjectAntimicrobial stewardship
dc.subjectinfection control
dc.subjectantibiotic resistance
dc.subjectbacterial
dc.subjectreview
dc.subjectsystematic
dc.subject.othertime-series analysis
dc.subject.otherstaphylococcus-aureus
dc.subject.otherclinical-outcomes
dc.subject.othereconomic outcomes
dc.subject.otherimpact
dc.subject.otherinfections
dc.subject.otherimplementation
dc.subject.otherusage
dc.subject.otherinterventions
dc.subject.otherconsumption
dc.subject.wosPublic, Environmental & Occupational Health
dc.subject.wosInfectious Diseases
dc.titleAre antimicrobial stewardship programs effective strategies for preventing antibiotic resistance? A systematic review
dc.typearticle
dc.type.categoryreview
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus41
hcfmusp.contributor.author-fmusphcLEANDRO PEDRO GOLONI BERTOLLO
hcfmusp.contributor.author-fmusphcDIEGO DA SILVA LUTKEMEYER
hcfmusp.contributor.author-fmusphcANNA SARA SHAFFERMAN LEVIN
hcfmusp.description.beginpage824
hcfmusp.description.endpage836
hcfmusp.description.issue7
hcfmusp.description.volume46
hcfmusp.origemWOS
hcfmusp.origem.pubmed29472107
hcfmusp.origem.scopus2-s2.0-85042166080
hcfmusp.origem.wosWOS:000436956200021
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
hcfmusp.relation.referenceAgwu AL, 2008, CLIN INFECT DIS, V47, P747, DOI 10.1086/591133
hcfmusp.relation.referenceAlawi MM, 2016, SAUDI MED J, V37, P1350, DOI 10.15537/smj.2016.12.15739
hcfmusp.relation.referenceBarbosa TM, 2000, DRUG RESIST UPDATE, V3, P303, DOI 10.1054/drup.2000.0167
hcfmusp.relation.referenceBartlett JG, 2013, CLIN INFECT DIS, V56, P1445, DOI 10.1093/cid/cit070
hcfmusp.relation.referenceBedini A, 2016, DIGEST LIVER DIS, V48, P1142, DOI 10.1016/j.dld.2016.06.023
hcfmusp.relation.referenceBurke JP, 1998, JAMA-J AM MED ASSOC, V280, P1270, DOI 10.1001/jama.280.14.1270
hcfmusp.relation.referenceCarlet J, 2011, LANCET, V378, P369, DOI 10.1016/S0140-6736(11)60401-7
hcfmusp.relation.referenceCassier P, 2011, CLIN MICROBIOL INFEC, V17, P1746, DOI 10.1111/j.1469-0691.2010.03349.x
hcfmusp.relation.referenceCenters for Disease Control and Prevention, 2013, OFF INF DIS ANT RES
hcfmusp.relation.referenceChan YY, 2011, INT J ANTIMICROB AG, V38, P486, DOI 10.1016/j.ijantimicag.2011.08.011
hcfmusp.relation.referenceChen CH, 2015, MED MALADIES INFECT, V45, P264, DOI 10.1016/j.medmal.2015.04.005
hcfmusp.relation.referenceCook PP, 2015, INT J ANTIMICROB AG, V45, P262, DOI 10.1016/j.ijantimicag.2014.11.006
hcfmusp.relation.referenceCostelloe C, 2010, BMJ-BRIT MED J, V340, DOI 10.1136/bmj.c2096
hcfmusp.relation.referenceDancer SJ, 2013, INT J ANTIMICROB AG, V41, P137, DOI 10.1016/j.ijantimicag.2012.10.013
hcfmusp.relation.referenceDavey P, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003543.pub3
hcfmusp.relation.referencede Kraker MEA, 2017, CLIN MICROBIOL INFEC, V23, P819, DOI 10.1016/j.cmi.2017.05.019
hcfmusp.relation.referencedel Arco A, 2015, EUR J CLIN MICROBIOL, V34, P247, DOI 10.1007/s10096-014-2225-5
hcfmusp.relation.referenceDellit TH, 2007, CLIN INFECT DIS, V44, P159, DOI 10.1086/510393
hcfmusp.relation.referenceDiazGranados CA, 2012, AM J INFECT CONTROL, V40, P526, DOI 10.1016/j.ajic.2011.07.011
hcfmusp.relation.referenceDoernberg SB, 2015, ANTIMICROB RESIST IN, V4, DOI 10.1186/s13756-015-0095-y
hcfmusp.relation.referenceEffective Practice and Organization of Care, 2015, EPOC RES REV AUTH
hcfmusp.relation.referenceGoossens H, 2005, LANCET, V365, P579, DOI 10.1016/S0140-6736(05)17907-0
hcfmusp.relation.referenceGuo W, 2015, AM J INFECT CONTROL, V43, P358, DOI 10.1016/j.ajic.2014.12.010
hcfmusp.relation.referenceHou DP, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0101447
hcfmusp.relation.referenceJenkins TC, 2015, INFECT CONT HOSP EP, V36, P664, DOI 10.1017/ice.2015.41
hcfmusp.relation.referenceKim YC, 2013, AM J INFECT CONTROL, V41, pE39, DOI 10.1016/j.ajic.2012.12.018
hcfmusp.relation.referenceKnudsen JG, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0084910
hcfmusp.relation.referenceLai CC, 2016, J MICROBIOL IMMUNOL, V49, P74, DOI 10.1016/j.jmii.2015.05.011
hcfmusp.relation.referenceLawes T, 2015, LANCET INFECT DIS, V15, P1438, DOI 10.1016/S1473-3099(15)00315-1
hcfmusp.relation.referenceLew KY, 2015, J ANTIMICROB CHEMOTH, V70, P1219, DOI 10.1093/jac/dku479
hcfmusp.relation.referenceLiew YX, 2012, INT J ANTIMICROB AG, V40, P55, DOI 10.1016/j.ijantimicag.2012.03.004
hcfmusp.relation.referenceLiu B, 2009, NUCLEIC ACIDS RES, V37, pD443, DOI 10.1093/nar/gkn656
hcfmusp.relation.referenceMacDougall C, 2005, CLIN MICROBIOL REV, V18, P638, DOI 10.1128/CMR.18.4.638-656.2005
hcfmusp.relation.referenceMalani AN, 2013, AM J INFECT CONTROL, V41, P145, DOI 10.1016/j.ajic.2012.02.021
hcfmusp.relation.referenceMorrill HJ, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0150795
hcfmusp.relation.referenceMunita JM, 2016, MICROBIOL SPECTR, V4, DOI 10.1128/microbiolspec.VMBF-0016-2015
hcfmusp.relation.referenceNijssen S, 2006, CLIN INFECT DIS, V43, P616, DOI 10.1086/506438
hcfmusp.relation.referenceNiwa T, 2012, INT J CLIN PRACT, V66, P999, DOI 10.1111/j.1742-1241.2012.02999.x
hcfmusp.relation.referenceNowak MA, 2012, AM J HEALTH-SYST PH, V69, P1500, DOI 10.2146/ajhp110603
hcfmusp.relation.referenceO'Brien KA, 2015, PHARMACOTHERAPY, V35, P464, DOI 10.1002/phar.1590
hcfmusp.relation.referenceOkumura LM, 2015, BRAZ J INFECT DIS, V19, P246, DOI 10.1016/j.bjid.2015.02.005
hcfmusp.relation.referenceSarma JB, 2015, J HOSP INFECT, V91, P68, DOI 10.1016/j.jhin.2015.05.006
hcfmusp.relation.referenceSchechner V, 2013, CLIN MICROBIOL REV, V26, P289, DOI 10.1128/CMR.00001-13
hcfmusp.relation.referenceTaggart LR, 2015, BMC INFECT DIS, V15, DOI 10.1186/s12879-015-1223-2
hcfmusp.relation.referenceViale P, 2015, CLIN MICROBIOL INFEC, V21, P242, DOI 10.1016/j.cmi.2014.10.020
hcfmusp.relation.referenceWong D, 2017, VIRULENCE, V8, P383, DOI 10.1080/21505594.2016.1188234
hcfmusp.relation.referenceWorld Health Organization, 2014, ANT RES GLOB REP SUR
hcfmusp.relation.referenceYoon Y., 2014, MICRONANOSYST LETT, V2, P1, DOI 10.1186/S40486-014-0003-X)
hcfmusp.relation.referenceZou YM, 2015, EUR J CLIN MICROBIOL, V34, P795, DOI 10.1007/s10096-014-2293-6
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