Influence of Serum Ferritin and B12 Levels in the Functional Outcomes of Patients with Ruptured and Unruptured Intracranial Aneurysms

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorRABELO, Nicollas Nunes
dc.contributor.authorCOELHO, Antonio Carlos Samaia da Silva
dc.contributor.authorPIPEK, Leonardo Zumerkorn
dc.contributor.authorTELLES, Joao Paulo Mota
dc.contributor.authorBARBATO, Natalia Camargo
dc.contributor.authorYOSHIKAWA, Marcia Harumy
dc.contributor.authorBARBOSA, Guilherme Bitencourt
dc.contributor.authorTEIXEIRA, Manoel Jacobsen
dc.contributor.authorFIGUEIREDO, Eberval Gadelha
dc.date.accessioned2024-02-15T14:48:22Z
dc.date.available2024-02-15T14:48:22Z
dc.date.issued2023
dc.description.abstractIntroduction Pathological processes in the arterial wall that result in vessel dilation are the cause of intracranial aneurysms (IAs), and the risk factors for their formation and progression are not well established. Ferritin is associated with inflammation and angiogenesis; it has protective antioxidative activity, and controls cell differentiation. Vitamin B12 is related to neurological and hematological disorders; it can be used as differential diagnosis tool, and acts in the control of homocysteinemia, a predictor of worse prognosis. The present article aims to assess the correlation between serum ferritin and B12 levels and the patient's functional outcome.Materials and Methods In the present cohort study, we assessed the serum levels of ferritin and B12, as well as the scores on the modified Rankin and Glasgow Outcome Scales at 6 months, of 2 groups, one with 19 and the other with 49 individuals, out of 401 patients treated for IA at Universidade de Sao Paulo from 2018 to 2019. We performed a statistical analysis, using logistic regression, to determine the aforementioned correlation.Results In the univariable analysis, the serum levels of ferritin showed no significant impact on the functional outcome (odds ratio [OR]: 0.96 for every 100 pg/mL increase; 95% confidence interval [95%CI]: 0.761-1.210; p = 0.732); neither did the serum levels of B12 (OR: 0.998 for every 100 pg/mL increase; 95%CI: 0.826-1.206; p = 0.987). Moreover, no significant impact on the functional outcome was observed in the multivariable analysis regarding the serum levels of B12, age, hypertension, and aneurysm rupture (OR: 1.086 for every 100 pg/mL increase; 95%CI: 0.847-1.392; p = 0.513).Conclusion We were not able to confirm a statistical correlation regarding the serum levels of ferritin and B12, and functional outcome of IA patients. These variables might be linked to other determinants of the pathophysiology of IAs, like inflammation and homocysteinemia.eng
dc.description.indexWoS
dc.identifier.citationBRAZILIAN NEUROSURGERY-ARQUIVOS BRASILEIROS DE NEUROCIRURGIA, v.42, n.4, p.E309-E315, 2023
dc.identifier.doi10.1055/s-0043-1774745
dc.identifier.eissn2359-5922
dc.identifier.issn0103-5355
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/57972
dc.language.isoeng
dc.publisherGEORG THIEME VERLAG KGeng
dc.relation.ispartofBrazilian Neurosurgery-Arquivos Brasileiros de Neurocirurgia
dc.rightsopenAccesseng
dc.rights.holderCopyright GEORG THIEME VERLAG KGeng
dc.subjectbrain aneurysmeng
dc.subjectruptured intracranial aneurysmeng
dc.subjectunruptured intracranial aneurysmeng
dc.subjectsubarachnoid hemorrhageeng
dc.subjectserum ferritineng
dc.subjectserum B12eng
dc.subject.otherabdominal aortic-aneurysmeng
dc.subject.othersubarachnoid hemorrhageeng
dc.subject.otherplasma homocysteineeng
dc.subject.otherironeng
dc.subject.othervitaminseng
dc.subject.othersafetyeng
dc.subject.otherriskeng
dc.subject.wosSurgeryeng
dc.titleInfluence of Serum Ferritin and B12 Levels in the Functional Outcomes of Patients with Ruptured and Unruptured Intracranial Aneurysmseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalBARBATO, Natalia Camargo:Ctr Univ Fac Amer, Neurol Dept, Sao Paulo, SP, Brazil
hcfmusp.contributor.author-fmusphcNICOLLAS NUNES RABELO
hcfmusp.contributor.author-fmusphcANTONIO CARLOS SAMAIA DA SILVA COELHO
hcfmusp.contributor.author-fmusphcLEONARDO ZUMERKORN PIPEK
hcfmusp.contributor.author-fmusphcJOAO PAULO MOTA TELLES
hcfmusp.contributor.author-fmusphcMARCIA HARUMY YOSHIKAWA
hcfmusp.contributor.author-fmusphcGUILHERME BITENCOURT BARBOSA
hcfmusp.contributor.author-fmusphcMANOEL JACOBSEN TEIXEIRA
hcfmusp.contributor.author-fmusphcEBERVAL GADELHA FIGUEIREDO
hcfmusp.description.beginpageE309
hcfmusp.description.endpageE315
hcfmusp.description.issue4
hcfmusp.description.volume42
hcfmusp.origemWOS
hcfmusp.origem.wosWOS:001106496200004
hcfmusp.publisher.citySTUTTGARTeng
hcfmusp.publisher.countryGERMANYeng
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