Effect of neoadjuvant chemotherapy on women undergoing breast cancer surgery and immediate breast reconstruction with latissimus dorsi flap and silicone implants

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorD'ALESSANDRO, Gabriel Salum
dc.contributor.authorPOVEDANO, Alejandro
dc.contributor.authorSANTOS, Lauren Klas Kurk Leme dos
dc.contributor.authorMUNHOZ, Alexandre Mendonca
dc.contributor.authorGEMPERLI, Rolf
dc.contributor.authorGOES, Joao Carlos de Sampaio
dc.date.accessioned2017-10-24T13:15:32Z
dc.date.available2017-10-24T13:15:32Z
dc.date.issued2017
dc.description.abstractThe use of the latissimus dorsi flap in immediate breast reconstruction is a relatively simple procedure using a flap with a very reliable and consistent vascularity. Neoadjuvant chemotherapy improves local surgical conditions; however, most chemotherapeutic agents are cytotoxic and may increase the risk of postoperative complications. This study evaluated the effects of neoadjuvant chemotherapy on women with cancer who underwent immediate breast reconstruction with latissimus dorsi flap and silicone implants. Data were collected from medical records of 102 patients with cancer who had undergone immediate breast reconstruction with latissimus dorsi flap and silicone implants from August 2010 to December 2014. Thirty-three patients received neoadjuvant chemotherapy (study group) and 69 patients underwent primary surgical treatment (control group). Three (2.9%) patients in the study group had a major postoperative complication (two cases of hematoma requiring surgical drainage and a case of flap necrosis), which was the only variable showing a significant difference between groups (P = 0.032). Neoadjuvant chemotherapy followed by cancer surgery with immediate breast reconstruction with latissimus dorsi flap and silicone implants was not associated with an increased risk of postoperative surgical and clinical minor complications. It was associated with a significant increase in postoperative major complications, despite the small number of cases. However, patients who received neoadjuvant chemotherapy had a significantly more aggressive disease and advanced-stage cancer, and required a more extensive cancer surgery.
dc.description.indexPubMed
dc.identifier.citationEUROPEAN JOURNAL OF PLASTIC SURGERY, v.40, n.4, p.299-308, 2017
dc.identifier.doi10.1007/s00238-016-1263-x
dc.identifier.eissn1435-0130
dc.identifier.issn0930-343X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/21768
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofEuropean Journal of Plastic Surgery
dc.rightsrestrictedAccess
dc.rights.holderCopyright SPRINGER
dc.subjectNeoadjuvant therapy
dc.subjectDrug therapy
dc.subjectMammaplasty
dc.subjectMyocutaneous flap
dc.subject.otherradical-mastectomy
dc.subject.othercomplications
dc.subject.otheroutcomes
dc.subject.wosSurgery
dc.titleEffect of neoadjuvant chemotherapy on women undergoing breast cancer surgery and immediate breast reconstruction with latissimus dorsi flap and silicone implants
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalD'ALESSANDRO, Gabriel Salum:Brazilian Inst Canc Control, Dept Breast Surg, Sao Paulo, SP, Brazil; Brazilian Inst Canc Control, Dept Plast Surg, Sao Paulo, SP, Brazil
hcfmusp.author.externalPOVEDANO, Alejandro:Brazilian Inst Canc Control, Dept Plast Surg, Sao Paulo, SP, Brazil
hcfmusp.author.externalSANTOS, Lauren Klas Kurk Leme dos:Brazilian Inst Canc Control, Dept Plast Surg, Sao Paulo, SP, Brazil
hcfmusp.author.externalGOES, Joao Carlos de Sampaio:Brazilian Inst Canc Control, Dept Breast Surg, Sao Paulo, SP, Brazil; Brazilian Inst Canc Control, Dept Plast Surg, Sao Paulo, SP, Brazil
hcfmusp.citation.scopus4
hcfmusp.contributor.author-fmusphcALEXANDRE MENDONCA MUNHOZ
hcfmusp.contributor.author-fmusphcROLF GEMPERLI
hcfmusp.description.beginpage299
hcfmusp.description.endpage308
hcfmusp.description.issue4
hcfmusp.description.volume40
hcfmusp.origemWOS
hcfmusp.origem.scopus2-s2.0-85007201692
hcfmusp.origem.wosWOS:000406283600006
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
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