Pneumocystis jirovecii pneumonia with an atypical granulomatous response after kidney transplantation

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorRAMALHO, J.
dc.contributor.authorMARQUES, I. D. Bacelar
dc.contributor.authorAGUIRRE, A. R.
dc.contributor.authorPIERROTTI, L. C.
dc.contributor.authorPAULA, F. J. de
dc.contributor.authorNAHAS, W. C.
dc.contributor.authorDAVID-NETO, E.
dc.date.accessioned2014-09-30T14:36:53Z
dc.date.available2014-09-30T14:36:53Z
dc.date.issued2014
dc.description.abstractPneumocystis jirovecii pneumonia (PCP) continues to be a leading cause of morbidity and mortality in kidney transplant recipients. Granulomatous PCP is an unusual histological presentation that has been described in a variety of immunosuppressive conditions. Previous studies have demonstrated an association between granulomatous disorders and hypercalcemia, the purported mechanism of which is extrarenal production of 1,25-dihydroxyvitamin D by activated macrophages. Here, we report a case of granulomatous formation in a kidney transplant recipient with PCP who presented with hypercalcemia and suppressed parathyroid hormone, both of which resolved after successful treatment of the pneumonia. In immunocompromised patients, pulmonary infection associated with hypercalcemia should raise the suspicion of PCP and other granulomatous disorders.
dc.description.indexMEDLINE
dc.identifier.citationTRANSPLANT INFECTIOUS DISEASE, v.16, n.2, p.315-319, 2014
dc.identifier.doi10.1111/tid.12198
dc.identifier.eissn1399-3062
dc.identifier.issn1398-2273
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/7310
dc.language.isoeng
dc.publisherWILEY-BLACKWELL
dc.relation.ispartofTransplant Infectious Disease
dc.rightsrestrictedAccess
dc.rights.holderCopyright WILEY-BLACKWELL
dc.subjecthypercalcemia
dc.subjectPneumocystis jirovecii
dc.subjectgranuloma
dc.subjectkidney transplantation
dc.subject.othercarinii-pneumonia
dc.subject.othervitamin-d
dc.subject.otherrenal-transplantation
dc.subject.otherhypercalcemia
dc.subject.otherpatient
dc.subject.othersarcoidosis
dc.subject.otheraids
dc.subject.otherhiv
dc.subject.wosImmunology
dc.subject.wosInfectious Diseases
dc.subject.wosTransplantation
dc.titlePneumocystis jirovecii pneumonia with an atypical granulomatous response after kidney transplantation
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalRAMALHO, J.:Univ Sao Paulo, Sch Med, Hosp Clin, Div Nephrol, Sao Paulo, Brazil
hcfmusp.citation.scopus16
hcfmusp.contributor.author-fmusphcIGOR DENIZARDE BACELAR MARQUES
hcfmusp.contributor.author-fmusphcANNA RITA MORAES DE SOUZA AGUIRRE MAZO
hcfmusp.contributor.author-fmusphcLIGIA CAMERA PIERROTTI
hcfmusp.contributor.author-fmusphcFLAVIO JOTA DE PAULA
hcfmusp.contributor.author-fmusphcWILLIAM CARLOS NAHAS
hcfmusp.contributor.author-fmusphcELIAS DAVID NETO
hcfmusp.description.beginpage315
hcfmusp.description.endpage319
hcfmusp.description.issue2
hcfmusp.description.volume16
hcfmusp.origemWOS
hcfmusp.origem.pubmed24621124
hcfmusp.origem.scopus2-s2.0-84897964536
hcfmusp.origem.wosWOS:000333969500017
hcfmusp.publisher.cityHOBOKEN
hcfmusp.publisher.countryUSA
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