Molecular characterisation of hepatitis B virus in the resident Chinese population in Panama City

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art_ALVARADO-MORA_Molecular_characterisation_of_hepatitis_B_virus_in_the_2013.PDF (915.02 KB)
Citações na Scopus
4
Tipo de produção
article
Data de publicação
2013
DOI
SciELO
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
FUNDACO OSWALDO CRUZ
Autores
MARTINEZ, Alexander Augusto
ZALDIVAR, Yamitzel
HONG, Chen Ch
SMITH, Rebecca
ORTIZ, Alma Y.
CRISTINA, Juan
PASCALE, Juan Miguel
Citação
MEMORIAS DO INSTITUTO OSWALDO CRUZ, v.108, n.5, p.541-547, 2013
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Despite the effectiveness of current hepatitis B virus (HBV) vaccines, it is estimated that 350 million individuals suffer from chronic HBV infection and more than 50% of these affected individuals live on the Asian continent. Panama is a country with a great diversity of foreign groups; the Chinese community is a large example of this phenomenon. There is an urgent need to perform studies that evaluate the prevalence and the genetic diversity of HBV in this community. This study aimed to evaluate the prevalence of HBV and its genotypes and mutant variants in the Chinese population residing in Panama. In total, 320 subjects were enrolled in the study. Forty-two subjects (13.1%) were positive for HBsAg and HBV-DNA from 18 subjects revealed the presence of genotypes B2 and C1. Secondary mutations associated with drug resistance at positions rtV207L and rtN239T of the reverse transcriptase gene were identified. Additionally, the mutation pair A1762T/G1764A was found in three samples and the mutation G1896A was detected in an HBeAg-negative subject. In conclusion, to our knowledge, this is the first study to report high HBV prevalence rates in resident ethnic Chinese in Central America and the presence of genotypes B2 and C1 in this region.
Palavras-chave
hepatitis B, Panama, Bayesian analysis, genotype C1, genotype B2
URI
https://observatorio.fm.usp.br/handle/OPI/4399
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Coleções
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/07
Artigos e Materiais de Revistas Científicas - ODS/03