Clinical predictors of acute response to transcranial direct current stimulation (tDCS) in major depression

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorD'URSO, Giordano
dc.contributor.authorDELL'OSSO, Bernardo
dc.contributor.authorROSSI, Rodolfo
dc.contributor.authorBRUNONI, Andre Russowsky
dc.contributor.authorBORTOLOMASI, Marco
dc.contributor.authorFERRUCCI, Roberta
dc.contributor.authorPRIORI, Alberto
dc.contributor.authorBARTOLOMEIS, Andrea de
dc.contributor.authorALTAMURA, Alfredo Carlo
dc.date.accessioned2017-10-24T13:24:38Z
dc.date.available2017-10-24T13:24:38Z
dc.date.issued2017
dc.description.abstractBackground: Transcranial direct current stimulation (tDCS) is a promising neuromodulation intervention for poor-responding or refractory depressed patients. However, little is known about predictors of response to this therapy. The present study aimed to analyze clinical predictors of response to tDCS in depressed patients. Methods: Clinical data from 3 independent tDCS trials on 171 depressed patients (including unipolar and bipolar depression), were pooled and analyzed to assess predictors of response. Depression severity and the underlying clinical dimensions were measured using the Hamilton Depression Rating Scale (HDRS) at baseline and after the tDCS treatment. Age, gender and diagnosis (bipolar/unipolar depression) were also investigated as predictors of response. Linear mixed models were fitted in order to ascertain which HDRS factors were associated with response to tDCS. Results: Age, gender and diagnosis did not show any association with response to treatment. The reduction in HDRS scores after tDCS was strongly associated with the baseline values of ""Cognitive Disturbances"" and ""Retardation"" factors, whilst the ""Anxiety/Somatization"" factor showed a mild association with the response. Limitations: Open-label design, the lack of control group, and minor differences in stimulation protocols. Conclusions: No differences in response to tDCS were found between unipolar and bipolar patients, suggesting that tDCS is effective for both conditions. ""Cognitive disturbance"", ""Retardation"", and ""Anxiety/Somatization"", were identified as potential clinical predictors of response to tDCS. These findings point to the pre-selection of the potential responders to tDCS, therefore optimizing the clinical use of this technique and the overall cost-effectiveness of the psychiatric intervention for depressed patients.
dc.description.indexMEDLINE
dc.identifier.citationJOURNAL OF AFFECTIVE DISORDERS, v.219, p.25-30, 2017
dc.identifier.doi10.1016/j.jad.2017.05.019
dc.identifier.eissn1573-2517
dc.identifier.issn0165-0327
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/22172
dc.language.isoeng
dc.publisherELSEVIER SCIENCE BV
dc.relation.ispartofJournal of Affective Disorders
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER SCIENCE BV
dc.subjectTranscranial direct current stimulation (tDCS)
dc.subjectTranscranial magnetic stimulation (TMS)
dc.subjectPredictors of response
dc.subjectMajor depression
dc.subjectMood disorders
dc.subjectBrain stimulation
dc.subjectPooled analysis
dc.subject.othertreatment-resistant depression
dc.subject.othermagnetic stimulation
dc.subject.otherautistic disorder
dc.subject.othercognitive control
dc.subject.othersymptoms
dc.subject.otherneurostimulation
dc.subject.otherschizophrenia
dc.subject.otherconnectivity
dc.subject.othermetaanalysis
dc.subject.otherperformance
dc.subject.wosClinical Neurology
dc.subject.wosPsychiatry
dc.titleClinical predictors of acute response to transcranial direct current stimulation (tDCS) in major depression
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryItália
hcfmusp.affiliation.countryisoit
hcfmusp.affiliation.countryisous
hcfmusp.author.externalD'URSO, Giordano:Univ Naples Federico II, Dept Neurosci Reprod & Odontostomatol Sci, Unit Psychiat, Naples, Italy
hcfmusp.author.externalDELL'OSSO, Bernardo:Univ Milan, Dept Psychiat, Milan, Italy; Policlin Milan, Fdn IRCCS Ca Granda, Milan, Italy; Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
hcfmusp.author.externalROSSI, Rodolfo:Univ Naples Federico II, Dept Neurosci Reprod & Odontostomatol Sci, Unit Psychiat, Naples, Italy
hcfmusp.author.externalBORTOLOMASI, Marco:Casa Cura Villa Santa Chiara, Quinto Valpantena, Verona, Italy
hcfmusp.author.externalFERRUCCI, Roberta:Policlin Milan, Fdn IRCCS Ca Granda, Milan, Italy; Univ Milan, Dept Hlth Sci, Milan, Italy
hcfmusp.author.externalPRIORI, Alberto:Univ Milan, Dept Hlth Sci, Milan, Italy; Univ Milan, Dipartimento Sci Salute, Clin Neurol 3, Milan, Italy
hcfmusp.author.externalBARTOLOMEIS, Andrea de:Univ Naples Federico II, Dept Neurosci Reprod & Odontostomatol Sci, Unit Psychiat, Naples, Italy
hcfmusp.author.externalALTAMURA, Alfredo Carlo:Univ Milan, Dept Psychiat, Milan, Italy; Policlin Milan, Fdn IRCCS Ca Granda, Milan, Italy
hcfmusp.citation.scopus47
hcfmusp.contributor.author-fmusphcANDRE RUSSOWSKY BRUNONI
hcfmusp.description.beginpage25
hcfmusp.description.endpage30
hcfmusp.description.volume219
hcfmusp.origemWOS
hcfmusp.origem.pubmed28505499
hcfmusp.origem.scopus2-s2.0-85019121917
hcfmusp.origem.wosWOS:000406463600004
hcfmusp.publisher.cityAMSTERDAM
hcfmusp.publisher.countryNETHERLANDS
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