Fat mass to fat-free mass ratio and its associations with clinical characteristics in asthma

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorRUGILA, Diery Fernandes
dc.contributor.authorOLIVEIRA, Joice Mara
dc.contributor.authorMACHADO, Felipe Vilaca Cavallari
dc.contributor.authorCORREIA, Natielly Soares
dc.contributor.authorPUZZI, Vitoria Cavalheiro
dc.contributor.authorPASSOS, Natalia Febrini Piassi
dc.contributor.authorFREITAS, Patricia Duarte
dc.contributor.authorPITTA, Fabio
dc.contributor.authorCARVALHO, Celso Ricardo Fernandes
dc.contributor.authorFURLANETTO, Karina Couto
dc.date.accessioned2022-10-26T14:22:30Z
dc.date.available2022-10-26T14:22:30Z
dc.date.issued2022
dc.description.abstractBackground: Fat mass to fat-free mass ratio (FM/FFM) assesses the combined effect of the balance between fat mass and fat-free mass. Aims: to evaluate the associations beetween FM/FFM and clinical outcomes in asthma and to compare clinical characteristics between individuals with higher and lower FM/FFM. Methods: 128 participants with asthma underwent anthropometric, spirometry and bioelectrical impedance assessments. Physical activity in daily life (PADL) was assessed by the Actigraph for 7 days. Daily dose of inhaled medication, steps of pharmacological treatment, Asthma Control Questionnaire, Asthma Quality of Life Questionnaire and Hospital Anxiety and Depression Scale were also assessed. Participants were classified into two groups according to the 50th percentile of reference values for FM/FFM. Results: Individuals with higher FM/FFM (n=75) used higher daily doses of inhaled corticosteroids, had worse lung function and fewer steps/day when compared to those with lower FM/FFM (n=53) (P <= 0.021). Associations were found between absolute values of FM/FFM with lung function (FEV1 and FVC [liters]): R-2=0.207 and 0.364;P<0.0001), and between the categories of lower or higher FM/FFM with steps of medication treatment (Cramer's V=0.218;P=0.016) and level of PADL (Cramer's V=0.236;P=0.009). The highest FM/FFM was a determining factor of physical inactivity (OR: 3.21;95%CI:1.17-8.78) and highest steps of pharmacological treatment (OR: 8.89;95%CI:1.23-64.08). Conclusion: Higher FM/FFM is significantly associated with worse clinical characteristics in individuals with asthma, such as higher doses of inhaled corticosteroids, worse lung function and fewer steps/day. Moreover, higher FM/FFM is a determining factor of physical inactivity and the highest steps of pharmacological treatment for asthma.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipCoordination for the Improvement of Higher Education Personnel (CAPES/PROSUP)
dc.description.sponsorshipNational Council for Scientific and Technological Development (CNPq)
dc.description.sponsorshipNational Foundation for the Development of Private Higher Education (FUNADESP)
dc.description.sponsorshipPitagoras-Unopar University
dc.description.sponsorshipUniversity of Sao Paulo
dc.identifier.citationHEART & LUNG, v.56, p.154-160, 2022
dc.identifier.doi10.1016/j.hrtlng.2022.07.006
dc.identifier.eissn1527-3288
dc.identifier.issn0147-9563
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/49193
dc.language.isoeng
dc.publisherMOSBY-ELSEVIEReng
dc.relation.ispartofHeart & Lung
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright MOSBY-ELSEVIEReng
dc.subjectAsthmaeng
dc.subjectBody compositioneng
dc.subjectRespiratory function testseng
dc.subjectDrug therapyeng
dc.subjectMotor activityeng
dc.subjectACQ Asthma Control Questionnaireeng
dc.subjectAQLQ Asthma Quality of Life Questionnaireeng
dc.subjectBMI, Body mass indexeng
dc.subjectFM, Fat masseng
dc.subjectFFM, Fat-free masseng
dc.subjectFM/FFM, Fat mass to fat-free mass ratioeng
dc.subjectFEV1, Forced expiratory volume in the first secondeng
dc.subjectFVC, Forced vital capacityeng
dc.subjectFEV1/FVC Forced expiratory volume in the first second to forced vital capacity ratioeng
dc.subjectGINA, Global Initiative for Asthmaeng
dc.subjectHADS, Hospital Anxiety and Depression Scaleeng
dc.subjectPADL, Physical Activity in Daily Lifeeng
dc.subject.otherbioelectrical-impedance analysiseng
dc.subject.otherphysical-activityeng
dc.subject.otherbody-fateng
dc.subject.othervalidationeng
dc.subject.otherpedometereng
dc.subject.wosCardiac & Cardiovascular Systemseng
dc.subject.wosNursingeng
dc.subject.wosRespiratory Systemeng
dc.titleFat mass to fat-free mass ratio and its associations with clinical characteristics in asthmaeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryHolanda
hcfmusp.affiliation.countryisonl
hcfmusp.author.externalRUGILA, Diery Fernandes:Pitagoras Unopar Univ UNOPAR, Postgrad Program Rehabil Sci, Londrina, Parana, Brazil; State Univ Londrina UEL, Dept Phys Therapy, Lab Res Resp Physiotherapy LFIP, Londrina, Parana, Brazil
hcfmusp.author.externalOLIVEIRA, Joice Mara:Pitagoras Unopar Univ UNOPAR, Postgrad Program Rehabil Sci, Londrina, Parana, Brazil; State Univ Londrina UEL, Dept Phys Therapy, Lab Res Resp Physiotherapy LFIP, Londrina, Parana, Brazil
hcfmusp.author.externalMACHADO, Felipe Vilaca Cavallari:State Univ Londrina UEL, Dept Phys Therapy, Lab Res Resp Physiotherapy LFIP, Londrina, Parana, Brazil; CIRO, Dept Res & Dev, Horn, Netherlands; Maastricht Univ, Fac Hlth Med & Life Sci, NUTRIM Sch Nutr & Translat Res Metab, Maastricht, Netherlands; Maastricht Univ, Dept Resp Med, Med Ctr MUMC, Maastricht, Netherlands
hcfmusp.author.externalCORREIA, Natielly Soares:Pitagoras Unopar Univ UNOPAR, Postgrad Program Rehabil Sci, Londrina, Parana, Brazil; State Univ Londrina UEL, Dept Phys Therapy, Lab Res Resp Physiotherapy LFIP, Londrina, Parana, Brazil
hcfmusp.author.externalPUZZI, Vitoria Cavalheiro:Pitagoras Unopar Univ UNOPAR, Postgrad Program Rehabil Sci, Londrina, Parana, Brazil; State Univ Londrina UEL, Dept Phys Therapy, Lab Res Resp Physiotherapy LFIP, Londrina, Parana, Brazil
hcfmusp.author.externalPITTA, Fabio:State Univ Londrina UEL, Dept Phys Therapy, Lab Res Resp Physiotherapy LFIP, Londrina, Parana, Brazil
hcfmusp.author.externalFURLANETTO, Karina Couto:Pitagoras Unopar Univ UNOPAR, Postgrad Program Rehabil Sci, Londrina, Parana, Brazil; State Univ Londrina UEL, Dept Phys Therapy, Lab Res Resp Physiotherapy LFIP, Londrina, Parana, Brazil
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcNATALIA FEBRINI PIASSI PASSOS
hcfmusp.contributor.author-fmusphcPATRICIA DUARTE FREITAS
hcfmusp.contributor.author-fmusphcCELSO RICARDO FERNANDES DE CARVALHO
hcfmusp.description.beginpage154
hcfmusp.description.endpage160
hcfmusp.description.volume56
hcfmusp.origemWOS
hcfmusp.origem.pubmed35908350
hcfmusp.origem.scopus2-s2.0-85135013369
hcfmusp.origem.wosWOS:000836381300004
hcfmusp.publisher.cityNEW YORKeng
hcfmusp.publisher.countryUSAeng
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Artigos e Materiais de Revistas Científicas - FM/MFT
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