HLA-DQA1/B1 alleles as putative susceptibility markers in congenital toxoplasmosis

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSHIMOKAWA, Paulo Tadashi
dc.contributor.authorTARGA, Lilia Spaleta
dc.contributor.authorYAMAMOTO, Lidia
dc.contributor.authorRODRIGUES, Jonatas Cristian
dc.contributor.authorKANUNFRE, Kelly Aparecida
dc.contributor.authorOKAY, Thelma Suely
dc.date.accessioned2016-10-17T16:40:21Z
dc.date.available2016-10-17T16:40:21Z
dc.date.issued2016
dc.description.abstractHost and parasite genotypes are among the factors associated with congenital toxoplasmosis pathogenesis. As HLA class II molecules play a key role in the immune system regulation, the aim of this study was to investigate whether HLA-DQA1/B1 alleles are associated with susceptibility or protection to congenital toxoplasmosis. One hundred and twenty-two fetuses with and 103 without toxoplasmosis were studied. The two study groups were comparable according to a number of socio-demographic and genetic variables. HLA alleles were typed by PCR-SSP. In the HLA-DQA1 region, the allele frequencies showed that *01:03 and *03:02 alleles could confer susceptibility ( OR= 3.06, p = 0.0002 and OR=9.60, p= 0.0001, respectively) as they were more frequent among infected fetuses. Regarding the HLA-DQB1 region, the *05: 04 allele could confer susceptibility ( OR = 6.95, p < 0.0001). Of the 122 infected fetuses, 10 presented susceptibility haplotypes contrasting with only one in the non-infected group. This difference was not statistically significant after correction for multiple comparison ( OR = 9.37, p=0.011). In the casuistic, there were two severely damaged fetuses with high parasite loads determined in amniotic fluid samples and HLA-DQA1 susceptibility alleles. In the present study, a discriminatory potential of HLA-DQA1/B1 alleles to identify susceptibility to congenital toxoplasmosis and the most severe cases has been shown.
dc.description.indexMEDLINE
dc.description.sponsorshipSao Paulo Research Foundation - FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo) [2010/15022-1]
dc.identifier.citationVIRULENCE, v.7, n.4, p.456-464, 2016
dc.identifier.doi10.1080/21505594.2016.1150401
dc.identifier.eissn2150-5608
dc.identifier.issn2150-5594
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/16267
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS INC
dc.relation.ispartofVirulence
dc.rightsrestrictedAccess
dc.rights.holderCopyright TAYLOR & FRANCIS INC
dc.subjectCongenital toxoplasmosis
dc.subjectGenetic polymorphism
dc.subjectGenetic susceptibility
dc.subjectHLA alleles
dc.subjectpolymerase chain reaction
dc.subject.otherpolymerase-chain-reaction
dc.subject.othersequence-specific primers
dc.subject.otheramniotic-fluid samples
dc.subject.othergondii infection
dc.subject.otherfollow-up
dc.subject.othermaternal reinfection
dc.subject.othermolecular diagnosis
dc.subject.othergestational-age
dc.subject.otherhuman-disease
dc.subject.otherhla system
dc.subject.wosImmunology
dc.subject.wosInfectious Diseases
dc.subject.wosMicrobiology
dc.titleHLA-DQA1/B1 alleles as putative susceptibility markers in congenital toxoplasmosis
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalSHIMOKAWA, Paulo Tadashi:Univ Sao Paulo, Inst Trop Med, Lab Seroepidemiol & Immunobiol, Sao Paulo, Brazil
hcfmusp.author.externalTARGA, Lilia Spaleta:Univ Sao Paulo, Inst Trop Med, Lab Seroepidemiol & Immunobiol, Sao Paulo, Brazil
hcfmusp.citation.scopus13
hcfmusp.contributor.author-fmusphcLIDIA YAMAMOTO
hcfmusp.contributor.author-fmusphcJONATAS CRISTIAN RODRIGUES
hcfmusp.contributor.author-fmusphcKELLY APARECIDA KANUNFRE
hcfmusp.contributor.author-fmusphcTHELMA SUELY OKAY
hcfmusp.description.beginpage456
hcfmusp.description.endpage464
hcfmusp.description.issue4
hcfmusp.description.volume7
hcfmusp.origemWOS
hcfmusp.origem.pubmed26856406
hcfmusp.origem.scopus2-s2.0-84962091885
hcfmusp.origem.wosWOS:000380006900012
hcfmusp.publisher.cityPHILADELPHIA
hcfmusp.publisher.countryUSA
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