Cortical Volume Differences in Subjects at Risk for Psychosis Are Driven by Surface Area

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorBUECHLER, Roman
dc.contributor.authorWOTRUBA, Diana
dc.contributor.authorMICHELS, Lars
dc.contributor.authorTHEODORIDOU, Anastasia
dc.contributor.authorMETZLER, Sibylle
dc.contributor.authorWALITZA, Susanne
dc.contributor.authorHANGGI, Jurgen
dc.contributor.authorKOLLIAS, Spyros
dc.contributor.authorROSSLER, Wulf
dc.contributor.authorHEEKEREN, Karsten
dc.date.accessioned2021-02-18T13:59:36Z
dc.date.available2021-02-18T13:59:36Z
dc.date.issued2020
dc.description.abstractIn subjects at risk for psychosis, the studies on gray matter volume (GMV) predominantly reported volume loss compared with healthy controls (CON). However, other important morphological measurements such as cortical surface area (CSA) and cortical thickness (CT) were not systematically compared. So far, samples mostly comprised subjects at genetic risk or at clinical risk fulfilling an ultra-high risk (UHR) criterion. No studies comparing UHR subjects with at-risk subjects showing only basic symptoms (BS) investigated the differences in CSA or CT. Therefore, we aimed to unravel the contribution of the 2 morphometrical measures constituting the cortical volume (CV) and to test whether these groups inhere different morphometric features. We conducted a surface-based morphometric analysis in 34 CON, 46 BS, and 39 UHR to examine between-group differences in CV, CSA, and CT vertex-wise across the whole cortex. Compared with BS and CON, UHR individuals presented increased CV in frontal and parietal regions, which was driven by larger CSA. These groups did not differ in CT. Yet, at-risk subjects who later developed schizophrenia showed thinning in the occipital cortex. Furthermore, BS presented increased CSA compared with CON. Our results suggest that volumetric differences in UHR subjects are driven by CSA while CV loss in converters seems to be based on cortical thinning. We attribute the larger CSA in UHR to aberrant pruning representing a vulnerability to develop psychotic symptoms reflected in different levels of vulnerability for BS and UHR, and cortical thinning to a presumably stress-related cortical decomposition.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipZurich Program for Sustainable Development of Mental Health Services (ZInEP)
dc.identifier.citationSCHIZOPHRENIA BULLETIN, v.46, n.6, p.1511-1519, 2020
dc.identifier.doi10.1093/schbul/sbaa066
dc.identifier.eissn1745-1701
dc.identifier.issn0586-7614
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/39603
dc.language.isoeng
dc.publisherOXFORD UNIV PRESSeng
dc.relation.ispartofSchizophrenia Bulletin
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright OXFORD UNIV PRESSeng
dc.subjectschizophreniaeng
dc.subjectsurface-based morphometryeng
dc.subjectcortical thicknesseng
dc.subjectprodromeeng
dc.subject.otherultra-high-riskeng
dc.subject.otheranterior cingulate cortexeng
dc.subject.otherclinical high-riskeng
dc.subject.othermental stateeng
dc.subject.otherschizophreniaeng
dc.subject.otherthicknesseng
dc.subject.otherbraineng
dc.subject.otherabnormalitieseng
dc.subject.otherindividualseng
dc.subject.othertransitioneng
dc.subject.wosPsychiatryeng
dc.titleCortical Volume Differences in Subjects at Risk for Psychosis Are Driven by Surface Areaeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryAlemanha
hcfmusp.affiliation.countryisoch
hcfmusp.affiliation.countryisode
hcfmusp.author.externalBUECHLER, Roman:Univ Hosp Psychiat Zurich, Zurich Program Sustainable Dev Mental Hlth Serv Z, Zurich, Switzerland; Univ Hosp Zurich, Dept Neuroradiol, Zurich, Switzerland
hcfmusp.author.externalWOTRUBA, Diana:Univ Hosp Psychiat Zurich, Zurich Program Sustainable Dev Mental Hlth Serv Z, Zurich, Switzerland; Univ Hosp Zurich, Dept Neuroradiol, Zurich, Switzerland
hcfmusp.author.externalMICHELS, Lars:Univ Hosp Zurich, Dept Neuroradiol, Zurich, Switzerland
hcfmusp.author.externalTHEODORIDOU, Anastasia:Univ Hosp Psychiat Zurich, Zurich Program Sustainable Dev Mental Hlth Serv Z, Zurich, Switzerland; Univ Hosp Psychiat Zurich, Dept Psychiat Psychotherapy & Psychosomat, Zurich, Switzerland
hcfmusp.author.externalMETZLER, Sibylle:Univ Hosp Psychiat Zurich, Zurich Program Sustainable Dev Mental Hlth Serv Z, Zurich, Switzerland
hcfmusp.author.externalWALITZA, Susanne:Univ Zurich, Dept Child & Adolescent Psychiat, Zurich, Switzerland
hcfmusp.author.externalHANGGI, Jurgen:Univ Zurich, Dept Psychol, Div Neuropsychol, Zurich, Switzerland
hcfmusp.author.externalKOLLIAS, Spyros:Univ Hosp Zurich, Dept Neuroradiol, Zurich, Switzerland
hcfmusp.author.externalHEEKEREN, Karsten:Univ Hosp Psychiat Zurich, Zurich Program Sustainable Dev Mental Hlth Serv Z, Zurich, Switzerland; Univ Hosp Psychiat Zurich, Dept Psychiat Psychotherapy & Psychosomat, Zurich, Switzerland; LVR Hosp, Dept Psychiat & Psychotherapy 1, Cologne, Germany
hcfmusp.citation.scopus14
hcfmusp.description.beginpage1511
hcfmusp.description.endpage1519
hcfmusp.description.issue6
hcfmusp.description.volume46
hcfmusp.origemWOS
hcfmusp.origem.pubmed32463880
hcfmusp.origem.scopus2-s2.0-85097113421
hcfmusp.origem.wosWOS:000607041400021
hcfmusp.publisher.cityOXFORDeng
hcfmusp.publisher.countryENGLANDeng
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