Hearing preservation using topical dexamethasone alone and associated with hyaluronic acid in cochlear implantation

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art_RAMOS_Hearing_preservation_using_topical_dexamethasone_alone_and_associated_2015.PDF (337.13 KB)
Citações na Scopus
15
Tipo de produção
article
Data de publicação
2015
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
INFORMA HEALTHCARE
Autores
Citação
ACTA OTO-LARYNGOLOGICA, v.135, n.5, p.473-477, 2015
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Conclusion: Topical dexamethasone associated with hyaluronic acid in cochlear implant surgery demonstrated a statistically significant difference in the preservation of low-frequency thresholds when compared with topical dexamethasone alone and a control group. Topical dexamethasone alone was not superior in hearing preservation when compared to the control group. Objective: To compare the effects of topical dexamethasone alone and associated with hyaluronic acid intraoperatively in hearing preservation in cochlear implantation. Methods: Eighteen severely to profoundly hearing-impaired adult patients with measurable hearing were divided into three groups preoperatively: cochlear implantation as a control group (group 1), cochlear implantation using topical dexamethasone intraoperatively (group 2), and cochlear implantation using topical dexamethasone associated with hyaluronic acid intraoperatively (group 3). Preimplant and postimplant low-frequency pure-tone averages (PTAs) were calculated from unaided audiograms at 125, 250, and 500 Hz. Results: The mean changes in the low-frequency PTA comparing postoperative against preoperative thresholds were 28.03 +/- 6.77 dB in group 1, 30 +/- 14.53 dB in group 2, and 7.23 +/- 6.12 dB in group 3. There was statistical difference when comparing group 3 with groups 1 and 2 using one-way ANOVA (p = 0.002) followed by Scheffe post hoc test.
Palavras-chave
Hearing loss, cochlear implant, pharmacotherapy
URI
https://observatorio.fm.usp.br/handle/OPI/9815
Referências
  1. BJURSTROM S, 1987, ACTA OTO-LARYNGOL, P62
  2. Carlson ML, 2011, OTOL NEUROTOL, V32, P962, DOI 10.1097/MAO.0b013e3182204526
  3. Chandrasekhar SS, 2000, OTOLARYNG HEAD NECK, V122, P521, DOI 10.1016/S0194-5998(00)70094-5
  4. Chandrasekhar SS, 2001, OTOL NEUROTOL, V22, P18, DOI 10.1097/00129492-200101000-00005
  5. Chang A, 2009, HEARING RES, V255, P67, DOI 10.1016/j.heares.2009.05.010
  6. D'Elia A, 2012, OTOL NEUROTOL, V33, P343, DOI 10.1097/MAO.0b013e3182487dbb
  7. Di Nardo W, 2007, AUDIOL NEURO-OTOL, V12, P165, DOI 10.1159/000099019
  8. Gantz Bruce J, 2006, Audiol Neurootol, V11 Suppl 1, P63, DOI 10.1159/000095616
  9. Garcia-Ibanez L, 2009, ACTA OTO-LARYNGOL, V129, P651, DOI 10.1080/00016480802369278
  10. Gstoettner W, 2004, ACTA OTO-LARYNGOL, V124, P348, DOI 10.1080/00016480410016432
  11. Huang Christie Qi, 2007, Cochlear Implants Int, V8, P123, DOI 10.1002/cii.336
  12. James DP, 2008, AUDIOL NEURO-OTOL, V13, P86, DOI 10.1159/000111780
  13. Kiefer J, 2004, ACTA OTO-LARYNGOL, V124, P272, DOI 10.1080/00016480310000755
  14. Laszig R, 2002, J LARYNGOL OTOL, V116, P371
  15. LEHNHARDT E, 1993, ADV OTO-RHINO-LARYNG, V48, P62
  16. Lenarz M, 2012, LARYNGOSCOPE, V122, P1126, DOI 10.1002/lary.23214
  17. Lenarz T, 2009, AUDIOL NEURO-OTOL, V14, P22, DOI 10.1159/000206492
  18. Rajan GP, 2012, LARYNGOSCOPE, V122, P190, DOI 10.1002/lary.22142
  19. Selivanova OA, 2005, OTOL NEUROTOL, V26, P890, DOI 10.1097/01.mao.0000185050.69394.48
  20. van de Water TR, 2010, ACTA OTO-LARYNGOL, V130, P308, DOI [10.1080/00016480903124655, 10.3109/00016480903124655]

Coleções
Artigos e Materiais de Revistas Científicas - FM/MOF
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/32