Nonthyroidal illnesses syndrome in full-term newborns with sepsis

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSILVA, Maria Helena Baptista Nunes da
dc.contributor.authorARAUJO, Maria Cristina Korbage de
dc.contributor.authorDINIZ, Edna Maria de Albuquerque
dc.contributor.authorCECCON, Maria Esther Jurfest Rivero
dc.contributor.authorCARVALHO, Werther Brunow de
dc.date.accessioned2016-02-24T16:52:55Z
dc.date.available2016-02-24T16:52:55Z
dc.date.issued2015
dc.description.abstractABSTRACT Objective To assess hormonal changes in nonthyroidal illness syndrome (NTIS) in full-term newborns (NT) with sepsis. Materials and methods We included 28 NT with sepsis divided into 2 groups according to the time of normalization of serum and clinical indicators of infection: group A(A), 16 NT with improvement in up to 8 days; and group B(B), 12 NT improvement after 8 days. Among the 28 NT, 15 NT progressed to septic shock, with 5 NT group A and 10 NT in group B. NT were excluded when they showed severe sepsis and asphyxia, and congenital malformations, as well as those whose mothers had thyroid disease and IUGR. Results 17 NT (60.7%) presented NTIS. Low T3 was observed in NTIS in 10 NT (58.8%), and low T4 and T3 in 5 NT (29.5%), all of them with septic shock. Two NT showed mixed changes (11.7%). After sepsis was cured, there was no hormonal change, except in 3 NT. Administration of dopamine, furosemide, and corticosteroids did not affect the results. Conclusions This study indicates that nonthyroidal illness syndrome may be transiently present during sepsis in full-term newborns, especially in cases of prolonged sepsis. Low T3 can occur without changes in reverse T3 (different from adults), and low T4 and T3 occur mainly in patients with septic shock. Arch Endocrinol Metab. 2015;59(6):528-34
dc.description.indexMEDLINE
dc.identifier.citationARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA, v.59, n.6, p.528-534, 2015
dc.identifier.doi10.1590/2359-3997000000111
dc.identifier.eissn1677-9487
dc.identifier.issn0004-2730
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/13056
dc.language.isoeng
dc.publisherSociedade Brasileira de Endocrinologia e Metabologia
dc.relation.ispartofArchives of Endocrinology and Metabolism
dc.rightsopenAccess
dc.rights.holderCopyright Sociedade Brasileira de Endocrinologia e Metabologia
dc.subjectFull-term newborn
dc.subjectthyroidal hormone
dc.subjectsepsis
dc.subjectseptic shock
dc.subject.otherEUTHYROID SICK SYNDROME
dc.subject.otherC-REACTIVE PROTEIN
dc.subject.otherNEONATAL THYROID-FUNCTION
dc.subject.otherANTIBIOTIC-THERAPY
dc.subject.otherSEPTIC SHOCK
dc.subject.otherHORMONE
dc.subject.otherCHILDREN
dc.subject.otherINFANTS
dc.subject.otherBINDING
dc.subject.otherINFECTION
dc.titleNonthyroidal illnesses syndrome in full-term newborns with sepsis
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus9
hcfmusp.contributor.author-fmusphcMARIA HELENA BAPTISTA NUNES DA SILVA
hcfmusp.contributor.author-fmusphcMARIA CRISTINA KORBAGE DE ARAUJO
hcfmusp.contributor.author-fmusphcEDNA MARIA DE ALBUQUERQUE DINIZ
hcfmusp.contributor.author-fmusphcMARIA ESTHER JURFEST RIVERO CECCON
hcfmusp.contributor.author-fmusphcWERTHER BRUNOW DE CARVALHO
hcfmusp.description.beginpage528
hcfmusp.description.endpage534
hcfmusp.description.issue6
hcfmusp.description.volume59
hcfmusp.origemWOS
hcfmusp.origem.pubmed26677087
hcfmusp.origem.scieloSCIELO:S2359-39972015000600528
hcfmusp.origem.scopus2-s2.0-84979547074
hcfmusp.origem.wosWOS:000368794500009
hcfmusp.publisher.citySão Paulo
hcfmusp.publisher.countryBRAZIL
hcfmusp.relation.referenceReisner BS, 1999, J CLIN MICROBIOL, V37, P2024
hcfmusp.relation.referenceEhl S, 1997, PEDIATRICS, V99, P216, DOI 10.1542/peds.99.2.216
hcfmusp.relation.referenceLacour AG, 2001, EUR J PEDIATR, V160, P95, DOI 10.1007/s004310000681
hcfmusp.relation.referenceStockigt JR, 1996, CLIN CHEM, V42, P188
hcfmusp.relation.referenceCHOPRA IJ, 1975, J CLIN ENDOCR METAB, V41, P911
hcfmusp.relation.referenceVANDENBERGHE G, 1994, CRIT CARE MED, V22, P1747
hcfmusp.relation.referencePeeters RP, 2005, J CLIN ENDOCR METAB, V90, P4559, DOI 10.1210/jc.2005-0535
hcfmusp.relation.referenceGoldsmit GS, 2011, J PERINAT MED, V39, P59, DOI 10.1515/JPM.2010.120
hcfmusp.relation.referenceDellinger RP, 2013, CRIT CARE MED, V41, P580, DOI 10.1097/CCM.0b013e31827e83af
hcfmusp.relation.referenceGolombek SG, 2008, SEMIN PERINATOL, V32, P413, DOI 10.1053/j.semperi.2008.09.010
hcfmusp.relation.referenceMUNRO SL, 1989, J CLIN ENDOCR METAB, V68, P1141
hcfmusp.relation.referenceEconomidou F, 2011, HORM-INT J ENDOCRINO, V10, P117
hcfmusp.relation.referenceDilli D, 2012, J CLIN RES PEDIATR E, V4, P66, DOI 10.4274/jcrpe.625
hcfmusp.relation.referenceFRANKLIN R, 1985, J PEDIATR-US, V106, P124, DOI 10.1016/S0022-3476(85)80481-9
hcfmusp.relation.referenceFRANKLIN R, 1985, J PEDIATR-US, V107, P599, DOI 10.1016/S0022-3476(85)80031-7
hcfmusp.relation.referenceGoldstein Brahm, 2005, Pediatr Crit Care Med, V6, P2, DOI 10.1097/01.PCC.0000149131.72248.E6
hcfmusp.relation.referenceGraf Hans, 2002, Arq Bras Endocrinol Metab, V46, P51, DOI 10.1590/S0004-27302002000100008
hcfmusp.relation.referenceGROSS I, 1984, PEDIATR RES, V18, P191
hcfmusp.relation.referenceHulst JM, 2006, CLIN NUTR, V25, P154, DOI 10.1016/j.clnu.2005.10.006
hcfmusp.relation.referenceKAPTEIN EM, 1980, J CLIN ENDOCR METAB, V51, P387
hcfmusp.relation.referenceLangton JE, 2002, ENDOCRIN METAB CLIN, V31, P159, DOI 10.1016/S0889-8529(01)00008-1
hcfmusp.relation.referenceLIM CF, 1988, J CLIN ENDOCR METAB, V67, P682
hcfmusp.relation.referenceNagaya T, 2000, J CLIN INVEST, V106, P393, DOI 10.1172/JCI7771
hcfmusp.relation.referenceSQUIRE EN, 1982, PEDIATR INFECT DIS J, V1, P85, DOI 10.1097/00006454-198203000-00004
hcfmusp.relation.referenceWILSON DM, 1982, J PEDIATR-US, V101, P113, DOI 10.1016/S0022-3476(82)80198-4
hcfmusp.relation.referenceYildizdas D, 2004, J PEDIATR ENDOCR MET, V17, P1435
hcfmusp.relation.reference2005, J Clin Endocrinol Metab, V90, P5613
hcfmusp.relation.reference2002, Indian J Pediatr, V69, P663
hcfmusp.relation.reference2005, Intensive Care Med, V31, P970
hcfmusp.relation.reference2000, Rev Endocr Metab Disord, V1, P43
hcfmusp.relation.reference2014, Front Endocrinol, V5
hcfmusp.relation.reference2009, Endocrine, V36, P355
hcfmusp.relation.reference1983, Ann Intern Med, V98, P946
hcfmusp.relation.referenceMoura Egberto G. de, 2004, Arq Bras Endocrinol Metab, V48, P40, DOI 10.1590/S0004-27302004000100006
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