Nanotubos de carbono aplicados às neurociências: perspectivas e desafios

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorOLIVEIRA, Virginia
dc.contributor.authorPEREIRA, Michele Munk
dc.contributor.authorBRANDAO, Humberto de Mello
dc.contributor.authorBRANDAO, Marcos Antonio Fernandes
dc.contributor.authorGATTAZ, Wagner Farid
dc.contributor.authorRAPOSO, Nadia Rezende Barbosa
dc.date.accessioned2017-11-27T16:34:35Z
dc.date.available2017-11-27T16:34:35Z
dc.date.issued2011
dc.description.abstractBackground: Carbon nanotubes (CNTs) are the most promising nanomaterials for therapeutic application in neurodegenerative diseases. Potential applications include systems for controlled drug delivery, electrical interfaces and substrates for cell growth. Objective: To describe the state of art, prospects and challenges of applying CNTs in neuroscience. Methods: There has been systematic search in Medline, Lilacs and SciELO, using the keywords ""carbon nanotubes"", ""drug delivery"", ""electrical interface"", ""tissue regeneration"", ""neuroscience"", ""nanotechnology"" and ""biocompatibility"", properly grouped. Results: The literature review showed controversies in studies on the biocompatibility of CNTs, although it has ratified its potential for neuromedicine and neuroscience. Discussion: These results highlight the need for modeling studies on the applications and interactions of nanostructures with biological systems.
dc.description.abstractIntrodução: Os nanotubos de carbono (NTCs) são os nanomateriais mais promissores para aplicação terapêutica em doenças neurodegenerativas. Aplicações potenciais incluem sistemas de liberação controlada de fármacos, interfaces elétricas e substratos para crescimento celular. Objetivo: Descrever o estado da arte e as perspectivas e desafios da aplicação dos NTCs nas neurociências. Métodos: Procedeu-se a uma busca sistemática nos indexadores Medline, Lilacs e SciELO, utilizando os descritores“ carbon nanotubes”, “drug delivery”, “electrical interface”, “tissue regeneration”, “neuroscience”, “biocompatibility” e “nanotechnology”, devidamente agrupados. Resultados: A revisão da literatura evidenciou controvérsias nos estudos relativos à biocompatibilidade dos NTCs, embora tenha ratificado o seu potencial para a neuromedicina e neurociências. Conclusão: Os dados obtidos apontam a necessidade de estudos padronizados sobre as aplicações e interações dessas nanoestruturas com os sistemas biológicos.
dc.description.indexPubMed
dc.identifier.citationREVISTA DE PSIQUIATRIA CLINICA, v.38, n.5, p.201-206, 2011
dc.identifier.issn0101-6083
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/23427
dc.language.isopor
dc.publisherUNIV SAO PAULO, INST PSIQUIATRIA
dc.relation.ispartofRevista de Psiquiatria Clinica
dc.rightsopenAccess
dc.rights.holderCopyright UNIV SAO PAULO, INST PSIQUIATRIA
dc.subjectCarbon nanotubes
dc.subjectdrug delivery
dc.subjectelectrical interface
dc.subjecttissue regeneration
dc.subjectneurobiology
dc.subjectNanotubos de carbono
dc.subjectliberação controlada de fármacos
dc.subjectinterface elétrica
dc.subjectregeneração tecidual
dc.subjectneurobiologia
dc.subject.otherbrain-machine interfaces
dc.subject.othercentral-nervous-system
dc.subject.otherdrug-delivery
dc.subject.otherneurodegenerative disorders
dc.subject.otheroxidative stress
dc.subject.otherneuronal growth
dc.subject.otherin-vitro
dc.subject.othercytotoxicity
dc.subject.otherfunctionalization
dc.subject.othercells
dc.subject.wosPsychiatry
dc.titleNanotubos de carbono aplicados às neurociências: perspectivas e desafios
dc.title.alternativeCarbon nanotubes applied in neuroscience: prospects and challenges
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalBRANDAO, Humberto de Mello:Embrapa Gado Leite, Juiz De Fora, MG, Brazil
hcfmusp.author.externalRAPOSO, Nadia Rezende Barbosa:FMUSP, Dept Psiquiatria, Lab Neurociencias LIM 27, Sao Paulo, Brazil; FMUSP, Inst Psiquiatria, Lab Neurociencias LIM 27, Sao Paulo, Brazil
hcfmusp.citation.scopus3
hcfmusp.contributor.author-fmusphcWAGNER FARID GATTAZ
hcfmusp.description.beginpage201
hcfmusp.description.endpage206
hcfmusp.description.issue5
hcfmusp.description.volume38
hcfmusp.origemWOS
hcfmusp.origem.scopus2-s2.0-80054791070
hcfmusp.origem.wosWOS:000296025500006
hcfmusp.publisher.citySAO PAULO
hcfmusp.publisher.countryBRAZIL
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