The use of statins is related to a lower PSA level after endoscopic enucleation of the prostate with holmium laser (HoLEP) for the treatment of BPH

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0
Tipo de produção
article
Data de publicação
2023
DOI
Scopus
Web of Science
PubMed
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Título do Volume
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SPRINGER
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Citação
WORLD JOURNAL OF UROLOGY, v.41, n.8, Special Issue, p.2149-2154, 2023
Projetos de Pesquisa
Unidades Organizacionais
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Resumo
ObjectiveTo determine the factors that may be associated with a 2-month high baseline level of Total Prostatic Specific Antigen (PSA) after endoscopic enucleation of the prostate with Holmium Laser (HoLEP).Materials and methodsRetrospective study of a prospectively collected database of adult males undergoing HoLEP at a single tertiary institution from September 2015 to February 2021. Pre-operative epidemiological, clinical characteristics and post-operative factors were analyzed and a multivariate analysis was performed to determine factors independently related to PSA decline.ResultsA total of 175 men aged 49-92 years with a prostate size ranging from 25 to 450 cc underwent HoLEP, and after excluding data from patients due to loss of follow-up or incomplete data, 126 patients were included in the final analysis. The patients were divided into group A (n = 84), which included patients with postoperative PSA nadir lower than 1 ng/ml, and group B(n = 42), with postoperative PSA levels greater than 1 ng/ml. In the univariate analysis there was a correlation between the variation of the PSA value and the percentage of resected tissue (p = 0.028), for each 1 g of resected prostate there was a reduction of 0.104 ng/mL, furthermore there was a difference between the means of age of group A (71.56 years) and group B (68.17 years) (p = 0.042). In the multivariate analysis, the use of statins and lower postoperative PSA levels (p = 0.024; HR = 3.71) were correlated.ConclusionsOur results indicate that PSA after HoLEP is correlated with patient's age, the presence of incidental prostate cancer, and the use of statins.
Palavras-chave
Prostate-specific antigen, Benign prostate hyperplasia, Enucleation holmium laser, Prostate, Outcome assessment
URI
https://observatorio.fm.usp.br/handle/OPI/55940
Referências
  1. Abedali ZA, 2020, J UROLOGY, V203, P304, DOI 10.1097/JU.0000000000000530
  2. Ahyai SA, 2020, WORLD J UROL, V38, P3207, DOI 10.1007/s00345-020-03126-x
  3. Martinez-Gonzalez MA, 2022, BRIT J NUTR, V127, P1415, DOI [10.1017/S0007114521002397, 10.1002/bco2.68]
  4. Barbosa JABA., 2018, REV MED, V97, P314, DOI [10.11606/issn.1679-9836.v97i3p314-319, DOI 10.11606/ISSN.1679-9836.V97I3P314-319]
  5. Bautista OM, 2003, CONTROL CLIN TRIALS, V24, P224, DOI 10.1016/S0197-2456(02)00263-5
  6. BERRY SJ, 1984, J UROLOGY, V132, P474, DOI 10.1016/S0022-5347(17)49698-4
  7. Bertaccini A, 2001, EUR UROL, V40, P13, DOI 10.1159/000049872
  8. Bhat A, 2022, WORLD J UROL, V40, P889, DOI 10.1007/s00345-021-03771-w
  9. Bortnick Eric M, 2019, Rev Urol, V21, P154
  10. Castellani D, 2018, UROLOGY, V119, P121, DOI 10.1016/j.urology.2018.05.024
  11. EAU Guidelines, 2022, EAU ANN C AMSTERDAM
  12. Elmansy HM, 2009, UROLOGY, V74, P1105, DOI 10.1016/j.urology.2009.06.039
  13. Etzioni RD, 2005, J UROLOGY, V174, P877, DOI 10.1097/01.ju.0000169255.64518.fb
  14. Fonseca RC, 2008, INT BRAZ J UROL, V34, P41, DOI 10.1590/S1677-55382008000100007
  15. Gilling P J, 1998, Curr Opin Urol, V8, P11, DOI 10.1097/00042307-199801000-00003
  16. Gilling PJ, 2008, EUR UROL, V53, P744, DOI 10.1016/j.eururo.2007.04.052
  17. Guo ZL, 2022, INT BRAZ J UROL, V48, P915, DOI [10.1590/s1677-5538.ibju.2021.0653, 10.1590/S1677-5538.IBJU.2021.0653]
  18. Hamilton Robert J, 2008, J Natl Cancer Inst, V100, P1511, DOI 10.1093/jnci/djn362
  19. Herrmann TRW, 2016, WORLD J UROL, V34, P1353, DOI 10.1007/s00345-016-1922-3
  20. Lambert E, 2021, WORLD J UROL, V39, P2621, DOI 10.1007/s00345-020-03444-0
  21. McConnell JD, 2003, NEW ENGL J MED, V349, P2387, DOI 10.1056/NEJMoa030656
  22. Murtola TJ, 2010, INT J CANCER, V127, P1650, DOI 10.1002/ijc.25165
  23. Parsons JK, 2020, J UROLOGY, V204, P799, DOI 10.1097/JU.0000000000001298
  24. STAMEY TA, 1987, NEW ENGL J MED, V317, P909, DOI 10.1056/NEJM198710083171501
  25. Tinmouth WW, 2005, J ENDOUROL, V19, P550, DOI 10.1089/end.2005.19.550
  26. Welch G, 2002, UROLOGY, V59, P245, DOI 10.1016/S0090-4295(01)01506-0
  27. Yin L, 2013, J ENDOUROL, V27, P604, DOI 10.1089/end.2012.0505

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCG
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/55
Artigos e Materiais de Revistas Científicas - ODS/03