Relationship between automated choroidal thickness measurements and retinal sensitivity using microperimetry in patients with myopia and different stages of myopic maculopathy

Página do item simplificado
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSILVA, Fillipe de Biaggi Borges da
dc.contributor.authorSILVA, Luis Claudio Pimentel
dc.contributor.authorCUNHA, Leonardo Provetti
dc.contributor.authorZACHARIAS, Leandro Cabral
dc.contributor.authorNAVAJAS, Eduardo V.
dc.contributor.authorMONTEIRO, Mario L. R.
dc.contributor.authorPRETI, Rony C.
dc.date.accessioned2024-04-05T19:33:19Z
dc.date.available2024-04-05T19:33:19Z
dc.date.issued2024
dc.description.abstractPurpose To assess the relationship between macular choroidal thickness (CT) measurements and retinal sensitivity (RS) in eyes with myopia and different stages of myopic maculopathy. Methods A masked, cross-sectional, and consecutive study involving patients with emmetropia/myopia (control group) and high myopia (HM) eyes. Automated choroidal thickness (CT) and manual outer retinal layer (ORL) thickness were acquired using swept-source optical coherence tomography, while retinal sensitivity (RS) assessed by microperimetry (MP3) in all regions of the macular Early Treatment Diabetic Retinopathy Study (ETDRS) grid. Comparisons were made between groups, and correlations were performed among these measurements, demographic and ocular parameters and myopic maculopathy classification. Results A total of 37 (74 eyes) patients were included in the study. The mean age was 39 +/- 13 years, and 28 patients (76%) were female. HM eyes exhibited inferior best-corrected visual acuity and a more advanced myopic maculopathy classification compared to the control group. The mean macular CT were 255 and 179 mu m in the control and HM eyes (P < 0.001), respectively. In the HM eyes, superior ETDRS region presented the greatest values. Mean RS in control and HM groups was 28 and 24 dB (P = 0.001), respectively. Inner temporal followed by superior, were the regions of higher RS. Mean ORL thickness was 83 and 79 mu m (P < 0.001), in the control and HM groups, respectively. The inner temporal ETDRS region presented the thickest measure. CT correlated significantly with RS (r = 0.41, P < 0.001) and ORL thickness, (r = 0.58, P < 0.001), which also correlated with RS (r = 0.40, P < 0.001). Spherical equivalent, axial length and myopic maculopathy stage were the parameters that most correlated with CT, RS and ORL thickness. For every 100 mu m increase in thickening of CT there was an average increase of 3.4 mu m in ORL thickness and 2.7 dB in RS. Myopic maculopathy classification demonstrated influence only with CT. Conclusion Myopia degree is related to ORL and choroidal thinning and deterioration of retinal sensitivity in some ETDRS regions of the macula. Choroidal thinning is associated to with a decline of retinal sensitivity, thinning of ORL, and worsening of myopic maculopathy classification, so new treatments are necessary to prevent myopia progression.eng
dc.description.indexPubMed
dc.description.indexScopus
dc.description.indexDimensions
dc.description.indexWoS
dc.identifier.citationINTERNATIONAL JOURNAL OF RETINA AND VITREOUS, v.10, n.1, article ID 26, 11p, 2024
dc.identifier.doi10.1186/s40942-024-00541-9
dc.identifier.eissn2056-9920
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/58931
dc.language.isoeng
dc.publisherBMCeng
dc.relation.ispartofInternational Journal of Retina and Vitreous
dc.rightsopenAccesseng
dc.rights.holderCopyright BMCeng
dc.subjectOptical coherence tomographyeng
dc.subjectMyopiaeng
dc.subjectHigh myopiaeng
dc.subjectRetinal sensitivityeng
dc.subjectMicroperimetryeng
dc.subjectPathologic myopiaeng
dc.subject.otherdegenerationeng
dc.subject.othereyeseng
dc.subject.wosOphthalmologyeng
dc.titleRelationship between automated choroidal thickness measurements and retinal sensitivity using microperimetry in patients with myopia and different stages of myopic maculopathyeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryCanadá
hcfmusp.affiliation.countryisoca
hcfmusp.author.externalNAVAJAS, Eduardo V.:Univ British Columbia, Div Ophthalmol, Vancouver, BC, Canada
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcFILLIPE DE BIAGGI BORGES DA SILVA
hcfmusp.contributor.author-fmusphcLUIS CLAUDIO PIMENTEL DA SILVA
hcfmusp.contributor.author-fmusphcLEONARDO PROVETTI CUNHA
hcfmusp.contributor.author-fmusphcLEANDRO CABRAL ZACHARIAS
hcfmusp.contributor.author-fmusphcMARIO LUIZ RIBEIRO MONTEIRO
hcfmusp.contributor.author-fmusphcRONY CARLOS PRETI
hcfmusp.description.articlenumber26
hcfmusp.description.issue1
hcfmusp.description.volume10
hcfmusp.origemWOS
hcfmusp.origem.dimensionspub.1169526237
hcfmusp.origem.pubmed38454499
hcfmusp.origem.scopus2-s2.0-85186904687
hcfmusp.origem.wosWOS:001181159000001
hcfmusp.publisher.cityLONDONeng
hcfmusp.publisher.countryENGLANDeng
hcfmusp.relation.referenceAdhi M, 2013, CURR OPIN OPHTHALMOL, V24, P213, DOI 10.1097/ICU.0b013e32835f8bf8eng
hcfmusp.relation.referenceBorges Fillipe B., 2024, Arq. Bras. Oftalmol., V87, pe2021, DOI 10.5935/0004-2749.2021-0377eng
hcfmusp.relation.referenceCao JT, 1998, ARCH OPHTHALMOL-CHIC, V116, P589, DOI 10.1001/archopht.116.5.589eng
hcfmusp.relation.referenceCw O., 1999, The human eye: structure and function, P57eng
hcfmusp.relation.referenceDuke-Elder SAD., 1970, Pathological myopia Duke-Elder's system of ophthalmology. refractive optics and refraction, P474eng
hcfmusp.relation.referenceFujiwara T, 2009, AM J OPHTHALMOL, V148, P445, DOI 10.1016/j.ajo.2009.04.029eng
hcfmusp.relation.referenceHAYREH SS, 1990, EYE, V4, P273, DOI 10.1038/eye.1990.39eng
hcfmusp.relation.referenceHolden BA, 2016, OPHTHALMOLOGY, V123, P1036, DOI 10.1016/j.ophtha.2016.01.006eng
hcfmusp.relation.referenceIkuno Y, 2017, RETINA-J RET VIT DIS, V37, P2347, DOI 10.1097/IAE.0000000000001489eng
hcfmusp.relation.referenceIkuno Y, 2009, INVEST OPHTH VIS SCI, V50, P3876, DOI 10.1167/iovs.08-3325eng
hcfmusp.relation.referenceJonas JB, 2014, EYE, V28, P113, DOI 10.1038/eye.2013.223eng
hcfmusp.relation.referenceLaishram M, 2017, J CLIN DIAGN RES, V11, pNC08, DOI 10.7860/JCDR/2017/25799.10213eng
hcfmusp.relation.referenceMatsuo NOS., 1978, Report of research, Tokyo: cocdiJeng
hcfmusp.relation.referenceMatsuura M, 2018, AM J OPHTHALMOL, V187, P1, DOI 10.1016/j.ajo.2017.12.002eng
hcfmusp.relation.referenceNickla DL, 2010, PROG RETIN EYE RES, V29, P144, DOI 10.1016/j.preteyeres.2009.12.002eng
hcfmusp.relation.referenceOhno H., 1983, Fol Ophthalmol Jpn, V43, P1244eng
hcfmusp.relation.referenceOhno-Matsui K, 2015, AM J OPHTHALMOL, V159, P877, DOI 10.1016/j.ajo.2015.01.022eng
hcfmusp.relation.referencePark UC, 2022, INVEST OPHTH VIS SCI, V63, DOI 10.1167/iovs.63.11.13eng
hcfmusp.relation.referencePATZ A, 1985, ARCH OPHTHALMOL-CHIC, V103, P1796, DOI 10.1001/archopht.1985.01050120030015eng
hcfmusp.relation.referenceQin YW, 2010, INVEST OPHTH VIS SCI, V51, P4451, DOI 10.1167/iovs.09-4642eng
hcfmusp.relation.referenceGermano RAS, 2016, ARQ BRAS OFTALMOL, V79, P214, DOI 10.5935/0004-2749.20160062eng
hcfmusp.relation.referenceSpaide RF, 2009, AM J OPHTHALMOL, V147, P801, DOI 10.1016/j.ajo.2008.12.010eng
hcfmusp.relation.referenceWang YY, 2019, INVEST OPHTH VIS SCI, V60, P2800, DOI 10.1167/iovs.18-26085eng
hcfmusp.relation.referenceWu PC, 2008, EYE, V22, P551, DOI 10.1038/sj.eye.6702789eng
hcfmusp.relation.referenceYe J, 2019, INVEST OPHTH VIS SCI, V60, P1714, DOI 10.1167/iovs.18-26086eng
hcfmusp.relation.referenceZaben A, 2015, RETINA-J RET VIT DIS, V35, P398, DOI 10.1097/IAE.0000000000000367eng
hcfmusp.relation.referenceZengin MO, 2014, BRIT J OPHTHALMOL, V98, P233, DOI 10.1136/bjophthalmol-2013-304044eng
hcfmusp.scopus.lastupdate2024-05-17
relation.isAuthorOfPublicationd45a08b8-e801-464c-b0f6-f9bc94f82809
relation.isAuthorOfPublication4fdc7474-abff-4c67-b194-79a031b41f43
relation.isAuthorOfPublicationafcc212d-a00c-4aad-bea3-7895026c0cf3
relation.isAuthorOfPublication4776bc95-698a-49ff-b8cb-d31953316997
relation.isAuthorOfPublication49360274-203b-489e-a263-d0aba4cb5be3
relation.isAuthorOfPublication043045f8-a0ae-47c9-861b-7a75c9cdee90
relation.isAuthorOfPublication.latestForDiscoveryd45a08b8-e801-464c-b0f6-f9bc94f82809
Arquivos
Coleções
Artigos e Materiais de Revistas Científicas - FM/MOF