Subclinical pulmonary abnormalities in childhood-onset systemic lupus erythematosus patients

Imagem de Miniatura
Arquivos
art_VEIGA_Subclinical_pulmonary_abnormalities_in_childhoodonset_systemic_lupus_erythematosus_2016.PDF (105.49 KB)
Citações na Scopus
11
Tipo de produção
article
Data de publicação
2016
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SAGE PUBLICATIONS LTD
Autores
LEONE, C.
Citação
LUPUS, v.25, n.6, p.645-651, 2016
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objective The aims of this study were to analyze the pulmonary function of childhood-onset systemic lupus erythematosus (cSLE) patients and to identify possible correlations between the high-resolution computed chest tomography (HRCT) score, disease activity, disease cumulative damage, and the participants' quality of life. Methods Forty cSLE patients, median age: 14.1 years (range: 7.4-17.9), underwent spirometry and plethysmography. Carbon monoxide diffusing capacity (DLCO), HRCT, disease activity, disease cumulative damage, and quality of life were assessed. Results Pulmonary abnormalities were evident in 19/40 (47.5%) cSLE patients according to spirometry/DLCO. Forced expired volume in one second (FEV1%) was the parameter most affected (30%). The HRCT showed some abnormality in 22/30 patients (73%), which were minimal in 43%. Signs of airway affects were found in 50%. Twelve patients were hospitalized due to cSLE-related pulmonary complications before the study began (median discharge: 2.1 years earlier). Total lung capacity (TLC%), vital capacity (VC%), forced vital capacity (FVC%), and FEV1% were significantly lower in the group with hospitalization compared to the group without hospitalization (p=0.0025, p=0.0022, p=0.0032, and p=0.0004, respectively). Of note, DLCO was positively correlated with disease duration (r=+0.4; p=0.01). The HRCT-score was negatively correlated with FEV1/VC (r=-0.63; p=0.0002), FEV1 (r=-0.54; p=0.018), FEF25%-75% (r=-0.67; p<0.0001), and HRCT-score was positively correlated with resistance (r=+0.49; p=0.0056). Conclusions Almost half of patients with cSLE had subclinical pulmonary abnormalities, especially airway abnormalities. The cSLE-related pulmonary complications seem to determine long-term functional damage.
Palavras-chave
Systemic lupus erythematosus, anti-DNA antibodies, vasculitis
URI
https://observatorio.fm.usp.br/handle/OPI/13956
Referências
  1. Abdulla Eiman, 2012, Oman Med J, V27, P36, DOI 10.5001/omj.2012.07
  2. CAEIRO F, 1981, ANN RHEUM DIS, V40, P325, DOI 10.1136/ard.40.4.325
  3. Priesnitz CV, 2009, PEDIATR PULM, V44, P1174, DOI 10.1002/ppul.21062
  4. Hadeli KO, 2001, CHEST, V120, P88, DOI 10.1378/chest.120.1.88
  5. BANKIER AA, 1995, RADIOLOGY, V196, P835
  6. STOCKS J, 1995, EUR RESPIR J, V8, P492, DOI 10.1183/09031936.95.08030492
  7. Pineles D, 2011, LUPUS, V20, P1187, DOI 10.1177/0961203311412096
  8. Geiger R, 2007, J PEDIATR-US, V150, P395, DOI 10.1016/j.jpeds.2006.12.052
  9. MacIntyre N, 2005, EUR RESPIR J, V26, P720, DOI 10.1183/09031936.05.00034905
  10. Hochberg MC, 1997, ARTHRITIS RHEUM, V40, P1725, DOI 10.1002/art.1780400928
  11. ANDONOPOULOS AP, 1988, CHEST, V94, P312, DOI 10.1378/chest.94.2.312
  12. Nakano M, 2002, RESPIROLOGY, V7, P45, DOI 10.1046/j.1440-1843.2002.00361.x
  13. Kamphuis S, 2010, NAT REV RHEUMATOL, V6, P538, DOI 10.1038/nrrheum.2010.121
  14. Gladman D, 1996, ARTHRITIS RHEUM, V39, P363, DOI 10.1002/art.1780390303
  15. Varni JW, 2003, AMBUL PEDIATR, V3, P329, DOI 10.1367/1539-4409(2003)003<0329:TPAAPP>2.0.CO;2
  16. Brenner DJ, 2001, AM J ROENTGENOL, V176, P289
  17. Silva MF, 2012, LUPUS, V21, P1011, DOI 10.1177/0961203312442752
  18. Ciftci E, 2004, RHEUMATOLOGY, V43, P587, DOI 10.1093/rheumatology/keh120
  19. Varni JW, 2002, J BEHAV MED, V25, P175, DOI 10.1023/A:1014836921812
  20. Varni JW, 1999, MED CARE, V37, P126, DOI 10.1097/00005650-199902000-00003
  21. Trapani S, 1998, LUPUS, V7, P545, DOI 10.1191/096120398678920631
  22. Midgley A, 2014, ARCH DIS CHILD, V99, P563, DOI 10.1136/archdischild-2013-304397
  23. POLGAR G, 1979, AM REV RESPIR DIS, V120, P625
  24. Bertoli AM, 2007, LUPUS, V16, P410, DOI 10.1177/0961203307079042
  25. Wanger J, 2005, EUR RESPIR J, V26, P511, DOI 10.1183/09031936.05.00035005
  26. Lilleby V, 2006, CLIN EXP RHEUMATOL, V24, P203
  27. DELGADO EA, 1990, SEMIN ARTHRITIS RHEU, V19, P285, DOI 10.1016/0049-0172(90)90051-G
  28. Fenlon HM, 1996, AM J ROENTGENOL, V166, P301
  29. Varni JW, 2001, MED CARE, V39, P800, DOI 10.1097/00005650-200108000-00006
  30. Machado CSM, 2001, CLIN EXP RHEUMATOL, V19, pS25
  31. DEJONGSTE JC, 1986, ARCH DIS CHILD, V61, P478
  32. Miller MR, 2005, EUR RESPIR J, V26, P319, DOI 10.1183/09031936.05.00034805
  33. Klatchoian DA, 2008, J PEDIAT-BRAZIL, V84, P308, DOI [10.2223/JPED.1788, 10.1590/S0021-75572008000400005]
  34. Cerveri I, 1996, THORAX, V51, P424, DOI 10.1136/thx.51.4.424
  35. Araujo DB, 2012, LUPUS, V21, P872, DOI 10.1177/0961203312441047
  36. Pellegrino R, 2005, EUR RESPIR J, V26, P948, DOI 10.1183/09031936.05.00035205
  37. Gladman DD, 2002, J RHEUMATOL, V29, P288
  38. Crapo RO, 2002, AM J RESP CRIT CARE, V166, P111, DOI 10.1164/rccm.166/1/111
  39. Carmier D, 2010, Rev Mal Respir, V27, pe66, DOI 10.1016/j.rmr.2010.01.003
  40. Mina R, 2013, ARTHRITIS RES THER, V15, DOI 10.1186/ar4256
  41. NADORRA R L, 1987, Pediatric Pathology, V7, P1
  42. Polgar G, 1971, PULOMARY FUNCTION TE
  43. Tsokos GC, 2011, NEW ENGL J MED, V365, P2110, DOI 10.1056/NEJMra1100359

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPE
Artigos e Materiais de Revistas Científicas - HC/ICr
Artigos e Materiais de Revistas Científicas - LIM/36